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Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.
Y Isaka, … , T Kamada, E Imai
Y Isaka, … , T Kamada, E Imai
Published December 1, 1993
Citation Information: J Clin Invest. 1993;92(6):2597-2601. https://doi.org/10.1172/JCI116874.
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Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

Abstract

Glomerulosclerosis, a final common lesion of various glomerular diseases, is characterized by mesangial cell proliferation and extracellular matrix (ECM) expansion. TGF-beta and PDGF are known to play a critical role in the regulation of ECM metabolism and mesenchymal cell proliferation, respectively. However, there is little evidence to demonstrate the direct role of each of these growth factors in the pathogenesis of glomerulosclerosis. Using an in vivo transfection technique, we could realize the selective overexpression of single growth factor in the kidney. The introduction of either TGF-beta or PDGF-B gene alone into the kidney induced glomerulosclerosis, although the patterns of action of these growth factors were different; TGF-beta affected ECM accumulation rather than cell proliferation and PDGF affected the latter rather than the former.

Authors

Y Isaka, Y Fujiwara, N Ueda, Y Kaneda, T Kamada, E Imai

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The Kidney
LM Satlin, CB Woda, GJ Schwartz 		The Kidney 2003
Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
HY Lan, W Mu, N Tomita, XR Huang, JH Li, HJ Zhu, R Morishita, RJ Johnson 		Journal of the American Society of Nephrology : JASN 2003
Elevated levels of beta defensin-1 mRNA in diabetic kidneys of GK rats
RA Page, AN Malik 		Biochemical and Biophysical Research Communications 2003
Renal Gene Transfer: Nonviral Approaches
YH Lien, LW Lai 		Molecular Biotechnology 2003
TGF-β signal transduction and mesangial cell fibrogenesis
HW Schnaper, T Hayashida, SC Hubchak, AC Poncelet 		American journal of physiology. Renal physiology 2003
Eicosapentaenoic acid inhibits PDGF-induced mitogenesis and cyclin D1 expression via TGF-? in mesangial cells
M Hida, H Fujita, K Ishikura, S Omori, M Hoshiya, M Awazu 		Journal of Cellular Physiology 2003
Excessive Matrix Accumulation in the Kidneys of MRL/ lpr Lupus Mice Is Dependent on Complement Activation
L Bao, J Zhou, VM Holers, RJ Quigg 		Journal of the American Society of Nephrology : JASN 2003
Signaling: Focus on Rho in Renal Disease
CC Sharpe, BM Hendry 		Journal of the American Society of Nephrology : JASN 2003
Differential Contribution of Three Mitogen-Activated Protein Kinases to PDGF-BB-Induced Mesangial Cell Proliferation and Gene Expression
H Kawano, S Kim, K Ohta, T Nakao, H Miyazaki, T Nakatani, H Iwao 		Journal of the American Society of Nephrology : JASN 2003
A Fully Human Monoclonal Antibody (CR002) Identifies PDGF-D as a Novel Mediator of Mesangioproliferative Glomerulonephritis
T Ostendorf, CR van Roeyen, JD Peterson, U Kunter, F Eitner, AJ Hamad, G Chan, XC Jia, J Macaluso, G Gazit-Bornstein, BA Keyt, HS Lichenstein, WJ LaRochelle, J Floege 		Journal of the American Society of Nephrology : JASN 2003
Transforming growth factor-beta1 is up-regulated by podocytes in response to excess intraglomerular passage of proteins: a central pathway in progressive glomerulosclerosis
M Abbate, C Zoja, M Morigi, D Rottoli, S Angioletti, S Tomasoni, C Zanchi, L Longaretti, R Donadelli, G Remuzzi 		The American Journal of Pathology 2002
RNA expression profiling as prognostic tool in renal patients: Toward nephrogenomics
M Eikmans, HJ Baelde, ED Heer, JA Bruijn 		Kidney International 2002
Activated intrarenal transcription of CTL-effectors and TGF-beta1 in children with focal segmental glomerulosclerosis
J Strehlau, AD Schachter, M Pavlakis, A Singh, A Tejani, TB Strom 		Kidney International 2002
Smad7 mediates transforming growth factor-beta-induced apoptosis in mesangial cells
T Okado, Y Terada, H Tanaka, S Inoshita, A Nakao, S Sasaki 		Kidney International 2002
RNA expression profiling as prognostic tool in renal patients: Toward nephrogenomics
M Eikmans, HJ Baelde, ED Heer, JA Bruijn 		Kidney International 2002
Platelet-derived growth factor-D expression in developing and mature human kidneys
S Changsirikulchai, KL Hudkins, TA Goodpaster, J Volpone, S Topouzis, DG Gilbertson, CE Alpers 		Kidney International 2002
Enhancement of Glomerular Platelet-Derived Growth Factor β-Receptor Tyrosine Phosphorylation in Hypertensive Rats and Its Inhibition by Calcium Channel Blocker
Y ZHAN, S KIM, H KAWANO, H IWAO 		Hypertension Research 2002
Differential expression of platelet-derived growth factor and transforming growth factor-β in relation to progression of IgA nephropathy
HW KIM, KC MOON, SY PARK, HK HONG, HS LEE 		Nephrology 2002
Novel collagen glomerulopathy in a homotrimeric type I collagen mouse (oim)
CL Phillips, BJ Pfeiffer, AM Luger, CL Franklin 		Kidney International 2002
Targeting growth factors to the kidney: myth or reality?
E Imai, Y Isaka 		Current Opinion in Nephrology and Hypertension 2002
Differential expression of platelet-derived growth factor and transforming growth factor-beta in relation to progression of IgA nephropathy
HW Kim, KC Moon, SY Park, HK Hong, HS Lee 		Nephrology 2002
Renal Protective Effect of Candesartan Cilexetil in Spontaneously Hypercholesterolemic Rats
T Matsuo, E Ishikawa, M Ohta, Y Shibouta, Y Ishimura, Y Imura, Y Sugiyama 		The Japanese Journal of Pharmacology 2002
Adenovirus-mediated gene transfer to renal glomeruli in rodents
X Ye, M Jerebtsova, XH Liu, Z Li, PE Ray 		Kidney International 2002
Kidney-Targeted Naked DNA Transfer by Retrograde Renal Vein Injection in Rats
H Maruyama, N Higuchi, Y Nishikawa, H Hirahara, N Iino, S Kameda, H Kawachi, E Yaoita, F Gejyo, JI Miyazaki 		Human Gene Therapy 2002
New Members of the Platelet-Derived Growth Factor Family of Mitogens
CH Heldin, U Eriksson, A Östman 		Archives of Biochemistry and Biophysics 2002
Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes
N Tomita, R Morishita, K Yamamoto, J Higaki, VJ Dzau, T Ogihara, Y Kaneda 		The Journal of Gene Medicine 2002
Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation
JH Li, HJ Zhu, XR Huang, KN Lai, RJ Johnson, HY Lan 		Journal of the American Society of Nephrology : JASN 2002
Soluble Transforming Growth Factor- β Type III Receptor Gene Transfection Inhibits Fibrous Airway Obliteration in a Rat Model of Bronchiolitis Obliterans
M Liu, M Suga, AL MacLEAN, JA St. George, DW Souza, S Keshavjee 		American journal of respiratory and critical care medicine 2002
Expression of endoglin in human mesangial cells: modulation of extracellular matrix synthesis
Luisa Diez-Marques, Rocio Ortega-Velazquez, Carmen Langa, Alicia Rodriguez-Barbero, Jose Miguel Lopez-Novoa, Santiago Lamas, Carmelo Bernabeu 		Biochimica et Biophysica Acta 2002
Decorin transfection in human mesangial cells downregulates genes playing a role in the progression of fibrosis
A Costacurta, G Priante, A D'Angelo, L Chieco-Bianchi, S Cantaro 		Journal of Clinical Laboratory Analysis 2002
Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542
NJ Laping, E Grygielko, A Mathur, S Butter, J Bomberger, C Tweed, W Martin, J Fornwald, R Lehr, J Harling, L Gaster, JF Callahan, BA Olson 		Molecular pharmacology 2002
The Effects of Platelet-Derived Growth Factor Antagonism in Experimental Glomerulonephritis Are Independent of the Transforming Growth Factor–β System
T Ostendorf, U Kunter, C van Roeyen, S Dooley, N Janjic, J Ruckman, F Eitner, J Floege 		Journal of the American Society of Nephrology : JASN 2002
It’s a Smad World: Regulation of TGF-β Signaling in the Kidney
HW Schnaper, T Hayashida, AC Poncelet 		Journal of the American Society of Nephrology : JASN 2002
Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases
K Matsumoto, T Nakamura 		Kidney International 2001
Electroporation-mediated PDGF receptor-IgG chimera gene transfer ameliorates experimental glomerulonephritis
H Nakamura, Y Isaka, M Tsujie, Y Akagi, T Sudo, N Ohno, E Imai, M Hori 		Kidney International 2001
Pathogenesis of diabetic nephropathy: focus on transforming growth factor-β and connective tissue growth factor
OV Sakharova, MW Taal, BM Brenner 		Current Opinion in Nephrology and Hypertension 2001
CONNECTIVE TISSUE GROWTH FACTOR AND ITS REGULATION: A NEW ELEMENT IN DIABETIC GLOMERULOSCLEROSIS
BL Riser, P Cortes 		Renal Failure 2001
Selenium-deficient diet induces renal oxidative stress and injury via TGF-beta1 in normal and diabetic rats
AS Reddi, JS Bollineni 		Kidney International 2001
Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy
S Mizuno, K Matsumoto, T Nakamura 		Kidney International 2001
Safety Evaluation of Hemagglutinating Virus of Japan–Artificial Viral Envelope Liposomes in Nonhuman Primates
N Tsuboniwa, R Morishita, T Hirano, J Fujimoto, S Furukawa, M Kikumori, A Okuyama, Y Kaneda 		Human Gene Therapy 2001
Prolonged transgene expression in glomeruli using an EBV replicon vector system combined with HVJ liposomes
M Tsujie, Y Isaka, H Nakamura, Y Kaneda, E Imai, M Hori 		Kidney International 2001
Effects of anti-TGF-beta type II receptor antibody on experimental glomerulonephritis
H Kasuga, Y Ito, S Sakamoto, H Kawachi, F Shimizu, Y Yuzawa, S Matsuo 		Kidney International 2001
Efficient Gene Transfer to Rat Renal Glomeruli with Recombinant Adenoviral Vectors
X Ye, XH Liu, Z Li, PE Ray 		Human Gene Therapy 2001
Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-β1-dependent mechanism in vitro
JM Fan, XR Huang, YY Ng, DJ Nikolic-Paterson, W Mu, RC Atkins, HY Lan 		American Journal of Kidney Diseases 2001
TGF-beta: a crucial component of the pathogenesis of diabetic nephropathy
S Goldfarb, FN Ziyadeh 		Transactions of the American Clinical and Climatological Association 2001
Non-penetrating Vascular Clips Anastomosis Inhibited Intimal Thickening Under Poor Runoff Conditions in Canine Autogenous Vein Grafts
K Komori, T Shoji, T Furuyama, Y Yonemitsu, E Mori, T Yamaoka, T Matsumoto, K Sugimachi 		European Journal of Vascular and Endovascular Surgery 2001
Is there hope for preventing or slowing the progression of chronic renal disease? More support for the role of growth factors
ED Crook 		American Journal of Kidney Diseases 2001
Stimulation of pro-α 1 (I) collagen by TGF-β 1 in mesangial cells: role of the p38 MAPK pathway
BY Chin, A Mohsenin, SX Li, AM Choi, ME Choi 		American journal of physiology. Renal physiology 2001
Physiology of Inflammation
K Ley 		2001
Gene Therapy for Acute and Acquired Diseases
P Factor 		2001
Macrophages Transfected with Adenovirus to Express IL-4 Reduce Inflammation in Experimental Glomerulonephritis
DC Kluth, CV Ainslie, WP Pearce, S Finlay, D Clarke, I Anegon, AJ Rees 		Journal of immunology (Baltimore, Md. : 1950) 2001
Effects of Retinoids on the TGF-β System and Extracellular Matrix in Experimental Glomerulonephritis
C Morath, C Dechow, I Lehrke, V Haxsen, R Waldherr, J Floege, E Ritz, J Wagner 		Journal of the American Society of Nephrology : JASN 2001
Electroporation-Mediated Gene Transfer that Targets Glomeruli
M Tsujie, Y Isaka, H Nakamura, E Imai, M Hori 		Journal of the American Society of Nephrology : JASN 2001
Modelling the effects of vascular stress in mesangial cells
BL Riser, P Cortes, J Yee 		Current Opinion in Nephrology and Hypertension 2000
Gene transfer targeting interstitial fibroblasts by the artificial viral envelope-type hemagglutinating virus of Japan liposome method1
M Tsujie, Y Isaka, Y Ando, Y Akagi, Y Kaneda, N Ueda, E Imai, M Hori 		Kidney International 2000
Hypertension-induced organ damage in african americans: Transforming growth factor-β1 excess as a mechanism for increased prevalence
P August, B Leventhal, M Suthanthiran 		Current Hypertension Reports 2000
Quantitation of mRNA expression in glomeruli using laser-manipulated microdissection and laser pressure catapulting
Y Nagasawa, M Takenaka, Y Matsuoka, E Imai, M Hori 		Kidney International 2000
Transforming growth factor-beta isoforms and glomerular injury in nephrotoxic nephritis
HM Wilson, AW Minto, PA Brown, LP Erwig, AJ Rees 		Kidney International 2000
Mechanism of transforming growth factor-beta1 signaling: Role of the mitogen-activated protein kinase
ME Choi 		Kidney International 2000
Age-Dependent Expression of Fibrosis-Related Genes and Collagen Deposition in Rat Kidney Cortex
N Gagliano, B Arosio, D Santambrogio, MR Balestrieri, G Padoani, J Tagliabue, S Masson, C Vergani, G Annoni 		The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2000
Expression of α-smooth muscle actin and fibronectin in tubulointerstitial lesions of cats with chronic renal failure
K Sawashima, S Mizuno, Y Mizuno-Horikawa, A Shimada, T Kudo, T Kurosawa 		American Journal of Veterinary Research 2000
Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology
JE Murphy-Ullrich, M Poczatek 		Cytokine & Growth Factor Reviews 2000
Etiology and pathophysiology of chronic transplant dysfunction
EA Kouwenhoven, JN IJzermans, RW Bruin 		Transplant International 2000
Distinctive Roles of Neutrophils and Monocytes in Anti-Thy-1 Nephritis
R Westerhuis, SC van Straaten, MG van Dixhoorn, N Rooijen, NA Verhagen, CD Dijkstra, E Heer, MR Daha 		The American Journal of Pathology 2000
Gene therapy for kidney disease
E Imai, Y Isaka 		Expert Opinion on Investigational Drugs 2000
Quantification of platelet-derived growth factor A, factor B and receptor beta in human renal biopsy tissue using competitive reverse transcriptase polymecase chain reaction: comparison between immunoglobulin A nephropathy and thin membrane nephropathy
RG Langham, MK Egan, JP DOWLING2, NM THOMSON1 		Nephrology 2000
Prospects for gene transfer into renal cells
V Kon, I Ichikawa 		Kidney International 2000
Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage
M Suthanthiran, B Li, JO Song, R Ding, VK Sharma, JE Schwartz, P August 		Proceedings of the National Academy of Sciences 2000
Immunohistochemical characterization of glomerular PDGF B-chain and PDGF β-receptor expression in diabetic rats
H Nakagawa, M Sasahara, M Haneda, D Koya, F Hazama, R Kikkawa 		Diabetes Research and Clinical Practice 2000
Transforming growth factor- 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage
M Suthanthiran, B Li, JO Song, R Ding, VK Sharma, JE Schwartz, P August 		Proceedings of the National Academy of Sciences 2000
Induction of TGF-beta1 by the matricellular protein SPARC in a rat model of glomerulonephritis
JA Bassuk, R Pichler, JD Rothmier, J Pippen, K Gordon, RL Meek, AD Bradshaw, D Lombardi, TP Strandjord, M Reed, EH Sage, WG Couser, R Johnson 		Kidney International 2000
Gene transfer into inflamed glomeruli using macrophages transfected with adenovirus
DC Kluth, LP Erwig, WP Pearce, AJ Rees 		Gene Therapy 2000
Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis
M Nagase, S Kaname, T Nagase, G Wang, K Ando, T Sawamura, T Fujita 		Journal of the American Society of Nephrology : JASN 2000
Transcriptional Regulation of Transforming Growth Factor β1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway
MC Daniels, DA McClain, ED Crook 		The American Journal of the Medical Sciences 2000
HIV-persistent infection and cytokine induction in mesangial cells: a potential mechanism for HIV-associated glomerulosclerosis:
PG Conaldi, A Bottelli, A Wade-Evans, L Biancone, A Baj, V Cantaluppi, C Serra, A Dolei, A Toniolo, G Camussi 		AIDS 2000
Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-β, fibronectin and renin
M Miyazaki, N Takemura, S Watanabe, N Hata, Y Misawa, H Okuyama 		Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2000
Transcription factor decoy for NFκB inhibits TNF-α-induced cytokine and adhesion molecule expression in vivo
N Tomita, R Morishita, S Tomita, GH Gibbons, L Zhang, M Horiuchi, Y Kaneda, J Higaki, T Ogihara, VJ Dzau 		Gene Therapy 2000
Glial cell line‐derived neurotrophic factor (GDNF) is expressed in the human kidney and is a growth factor for human mesangial cells
SR Orth, E Ritz, C SuterCrazzolara 		Nephrology Dialysis Transplantation 2000
Glomerular filtration is required for transfection of proximal tubular cells in the rat kidney following injection of DNA complexes into the renal artery
C Foglieni, A Bragonzi, M Cortese, L Cantù, A Boletta, I Chiossone, MR Soria, L Monaco 		Gene Therapy 2000
Transcriptional Regulation of Transforming Growth Factor ??1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway:
MC Daniels, DA McClain, ED Crook 		The American Journal of the Medical Sciences 2000
THE ROLE OF TRANSFORMING GROWTH FACTOR BETA IN CHRONIC RENAL ALLOGRAFT NEPHROPATHY:
S Jain, PN Furness, ML Nicholson 		Transplantation 2000
The Kidney and Hypertension in Diabetes Mellitus
CE Mogensen 		2000
Administration of IgG Fc Fragments Prevents Glomerular Injury in Experimental Immune Complex Nephritis
C Gómez-Guerrero, N Duque, MT Casado, Carlos, J Blanco, F Mampaso, F Vivanco, J Egido 		Journal of immunology (Baltimore, Md. : 1950) 2000
In Vivo Administration of a Nuclear Transcription Factor-κB Decoy Suppresses Experimental Crescentic Glomerulonephritis
N Tomita, R Morishita, HY Lan, K Yamamoto, M Hashizume, M Notake, K Toyosawa, B Fujitani, W Mu, DA Nikolic-Paterson, RC Atkins, Y Kaneda, J Higaki, T Ogihara 		Journal of the American Society of Nephrology : JASN 2000
Changes in pulmonary histology and exfoliated bronchoalveolar cells induced by in vivo introduction of the tumor necrosis factor-alpha gene
J Sakuma-Mochizuki, M Yoshida, K Abe, T Arai, M Mori, Y Kaneda, S Hayashi 		Inflammation 2000
Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice
RJ Fern, CM Yesko, BA Thornhill, HS Kim, O Smithies, RL Chevalier 		Journal of Clinical Investigation 1999
TGF-beta receptor expression and binding in rat mesangial cells: Modulation by glucose and cyclic mechanical strain
BL Riser, S Ladson-Wofford, A Sharba, P Cortes, K Drake, CJ Guerin, J Yee, ME Choi, PR Segarini, RG Narins 		Kidney International 1999
Gene therapy by transforming growth factor-beta receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis
Y Isaka, Y Akagi, Y Ando, M Tsujie, T Sudo, N Ohno, WA Border, NA Noble, Y Kaneda, M Hori, E Imai 		Kidney International 1999
Effect of candesartan cilexetil (TCV-116) in rats with chronic renal failure
M Noda, T Matsuo, R Fukuda, M Ohta, H Nagano, Y Shibouta, T Naka, K Nishikawa, Y Imura 		Kidney International 1999
Heparin-binding EGF-like growth factor is expressed by mesangial cells and is involved in mesangial proliferation in glomerulonephritis
T Takemura, Y Murata, S Hino, M Okada, H Yanagida, M Ikeda, K Yoshioka 		The Journal of Pathology 1999
The transforming growth factor beta system in kidney disease and repair: recent progress and future directions
DP Basile 		Current Opinion in Nephrology and Hypertension 1999
Regulation of mesangial cell proliferation
HO Schocklmann, S Lang, RB Sterzel 		Kidney International 1999
Regulation of cyclin D1 expression and cell cycle progression by mitogen-activated protein kinase cascade
Y Terada, S Inoshita, O Nakashima, M Kuwahara, S Sasaki, F Marumo 		Kidney International 1999
Increased levels of transforming growth factor-beta in HIV-associated nephropathy
T Yamamoto, NA Noble, DE Miller, LI Gold, A Hishida, M Nagase, AH Cohen, WA Border 		Kidney International 1999
Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats
J Torras, JM Cruzado, M Riera, E Condom, N Duque, I Herrero, M Merlos, L Espinosa, N Lloberas, J Egido, JM Grinyo 		Kidney International 1999
Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis
KA Munger, A Montero, M Fukunaga, S Uda, T Yura, E Imai, Y Kaneda, JM Valdivielso, KF Badr 		Proceedings of the National Academy of Sciences 1999
Direct in vivo gene transfer to healing rat patellar ligament by intra-arterial delivery of haemagglutinating virus of Japan liposomes
Ozkan, Shino, Nakamura, Natsu-ume, Matsumoto, Horibe, Tomita, Kaneda, Ochi 		European Journal of Clinical Investigation 1999
Role and interaction of connective tissue growth factor with transforming growth factor-? in persistent fibrosis: A mouse fibrosis model
T Mori, S Kawara, M Shinozaki, N Hayashi, T Kakinuma, A Igarashi, M Takigawa, T Nakanishi, K Takehara 		Journal of Cellular Physiology 1999
Expression profile of extracellular matrix and its regulatory proteins during the process of interstitial fibrosis after anti-glomerular basement membrane antibody-induced glomerular sclerosis in Sprague-Dawley rats
LP Adhikary, T Yamamoto, M Isome, Y Nakano, K Kawasaki, E Yaoita, I Kihara 		Pathology International 1999
Regulation of glomerular cell number by apoptosis
J Savill 		Kidney International 1999
Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro
JM Fan, YY Ng, PA Hill, DJ Nikolic-Paterson, W Mu, RC Atkins, HY Lan 		Kidney International 1999
TGF-β and fibrosis
MH Branton, JB Kopp 		Microbes and Infection 1999
Progression of renal disease in interleukin-4 transgenic mice: involvement of transforming growth factor-β
BM Rüger, Q Hasan, KJ Erb, PF Davis 		International Journal of Experimental Pathology 1999
Sodium bicarbonate treatment reduces renal injury, renal production of transforming growth Factor-β, and urinary transforming growth Factor-β excretion in rats with doxorubicin-induced nephropathy
EA Baroni, RS Costa, R Volpini, TM Coimbra 		American Journal of Kidney Diseases 1999
Evidence for Distinct Signaling Properties and Biological Responses Induced by the PDGF Receptor α and β Subtypes
S Rosenkranz, A Kazlauskas 		Growth Factors 1999
Gene transfer in the kidney
VR Kelley, VP Sukhatme 		American journal of physiology. Renal physiology 1999
Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor
CH Heldin, B Westermark 		Physiological reviews 1999
Transforming growth factor beta activity in urine of patients with type 2 diabetes and diabetic nephropathy
EW Rivarola, M Moyses-Neto, M Dantas, CG da-Silva, R Volpini, TM Coimbra 		Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 1999
Intragraft expression of transforming growth factor beta1 gene in isolated glomeruli from human renal transplants
ML Nicholson, GR Bicknell, G Barker, TM Doughman, ST Williams, PN Furness 		The British journal of surgery 1999
TRANSFORMING GROWTH FACTOR (TGF)-?? MIMICS AND ANTI-TGF-?? ANTIBODY ABROGATES THE IN VIVO EFFECTS OF CYCLOSPORINE: Demonstration of a Direct Role of TGF-?? in Immunosuppression and Nephrotoxicity of Cyclosporine
AK Khanna, VR Cairns, CG Becker, JD Hosenpud 		Transplantation 1999
Cytokines in Severe Sepsis and Septic Shock
H Redl, G Schlag 		1999
Molecular and Cellular Pediatric Endocrinology
S Handwerger 		1999
Gene Therapy for Diabetic Nephropathy
M Kitamura 		Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 1999
Favorable Treatment Outcome with Neutralizing anti Transforming Growth Factor I:} Antibodies in Experimental Diabetic Kidney Disease
DC Han, FN Ziyadeh 		Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 1999
Transduction of Renal Cells in Vitro and in Vivo by Adeno-Associated Virus Gene Therapy Vectors
MS Lipkowitz, B Hanss, N Tulchin, PD Wilson, JC Langer, MD Ross, GJ Kurtzman, PE Klotman, ME Klotman 		Journal of the American Society of Nephrology : JASN 1999
Transforming Growth Factor-β Is a Potent Inhibitor of Extracellular Matrix Degradation by Cultured Human Mesangial Cells
WH Baricos, SL Cortez, M Deboisblanc, S XIN 		Journal of the American Society of Nephrology : JASN 1999
α1β1 Integrin-Mediated Collagen Matrix Remodeling by Rat Mesangial Cells Is Differentially Regulated by Transforming Growth Factor-β and Platelet-Derived Growth Factor-BB
S Kagami, S Kondo, K Löster, W Reutter, T Kuhara, K Yasutomo, Y Kuroda 		Journal of the American Society of Nephrology : JASN 1999
Effects of Transforming Growth Factor-β1 on Renal Extracellular Matrix Components and Their Regulating Proteins
JA Douthwaite, TS Johnson, JL Haylor, P Watson, AM Nahas 		Journal of the American Society of Nephrology : JASN 1999
Renal Expression of Fibrotic Matrix Proteins and of Transforming Growth Factor-β (TGF-β) Isoforms in TGF-β Transgenic Mice
MM Mozes, EP Böttinger, TA Jacot, JB Kopp 		Journal of the American Society of Nephrology : JASN 1999
Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy
G Pugliese, F Pricci, G Romeo, G Leto, L Amadio, C Iacobini, UD Mario 		Journal of Endocrinological Investigation 1999
High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells
V Kolm-Litty, U Sauer, A Nerlich, R Lehmann, ED Schleicher 		Journal of Clinical Investigation 1998
Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease
S Mizuno, T Kurosawa, K Matsumoto, Y Mizuno-Horikawa, M Okamoto, T Nakamura 		Journal of Clinical Investigation 1998
Thrombospondin 1 precedes and predicts the development of tubulointerstitial fibrosis in glomerular disease in the rat
C Hugo, SJ Shankland, RH Pichler, WG Couser, RJ Johnson 		Kidney International 1998
Effects of hypertonic stress on transforming growth factor-beta activity in normal rat kidney cells
T Sugiura, A Yamauchi, H Kitamura, Y Matusoka, M Horio, E Imai, M Hori 		Kidney International 1998
Targeting TGF-beta overexpression in renal disease: Maximizing the antifibrotic action of angiotensin II blockade
H Peters, WA Border, NA Noble 		Kidney International 1998
Preventive effect of ACE inhibitor on interstitial myofibroblast formation and matrix deposition in a nephrotic model
S Mizuno, Y Horikawa, M Okamoto, T Kurosawa 		Renal Failure 1998
Transforming growth factor-β (TGF-β) activity in urine of patients with glomerulonephritis is related to their renal functional and structural changes
G Dominguez, R Costa, M Dantas, T Kimachi, C Piuci, T Coimbra 		Nephrology 1998
Gene transfer of RANTES elicits autoimmune renal injury in MRL-Faslpr mice
KJ Moore, T Wada, SD Barbee, VR Kelley 		Kidney International 1998
Fibronectin synthesis by human tubular epithelial cells in culture: Effects of PDGF and TGF-beta on synthesis and splicing
A Burger, C Wagner, C Viedt, B Reis, F Hug, GM Hansch 		Kidney International 1998
Switching off renal inflammation by anti-inflammatory mediators: The facts, the promise and the hope
L Baud, B Fouqueray, A Bellocq 		Kidney International 1998
Strategies of gene transfer to the kidney
E Imai, Y Isaka 		Kidney International 1998
Expression of platelet-derived growth factor and its receptors in the developing and adult mouse kidney
RA Seifert, CE Alpers, DF Bowen-Pope 		Kidney International 1998
Expression and its role of heparin-binding epidermal growth factor-like growth factor for the progression of glomerulonephritis
Y Murata, T Takemura, H Yanagida, S Hino, M Okada, K Yoshioka 		Nihon Shoni Jinzobyo Gakkai Zasshi 1998
TGF-β: A Balancing Act
NL McCartney-Francis, M Frazier-Jessen, SM Wahl 		International Reviews of Immunology 1998
Cationic Liposomes Enhance Adenovirus Entry via a Pathway Independent of the Fiber Receptor andαv-Integrins
C Qiu, MB de Young, A Finn, DA Dichek 		Human Gene Therapy 1998
Stimulatory Effect of Lipoprotein (a) on Proliferation of Human Mesangial Cells: Role of Lipoprotein (a) in Renal Disease
R Morishita, K Yamamoto, S Yamada, H Matsushita, N Tomita, I Sakurabayashi, Y Kaneda, A Moriguchi, J Higaki, T Ogihara 		Biochemical and Biophysical Research Communications 1998
Establishment of the Enzyme-Linked Immunosorbent Assay for Connective Tissue Growth Factor (CTGF) and Its Detection in the Sera of Biliary Atresia
T Tamatani, H Kobayashi, K Tezuka, S Sakamoto, K Suzuki, T Nakanishi, M Takigawa, T Miyano 		Biochemical and Biophysical Research Communications 1998
Atherogenic lipoproteins enhance mesangial cell expression of platelet-derived growth factor: Role of protein tyrosine kinase and cyclic amp-dependent protein kinase A
H Ha, DD Roh, MA Kirschenbaum, VS Kamanna 		Journal of Laboratory and Clinical Medicine 1998
Beneficial Effects of a Novel Inhibitor of Platelet-Derived Growth Factor Receptor Autophosphorylation in the Rat with Mesangial Proliferative Glomerulonephritis
M Yagi, S Kato, Y Kobayashi, N Kobayashi, N Iinuma, K Nakamura, K Kubo, SI Ohyama, H Murooka, T Shimizu, T Nishitoba, T Osawa, N Nagano 		General Pharmacology: The Vascular System 1998
Upregulated expression of fibroblast growth factor (FGF) receptors by transforming growth factor-beta1 (TGF-beta1) mediates enhanced mitogenic responses to FGFs in cultured human lung fibroblasts
VJ Thannickal, KD Aldweib, T Rajan, BL Fanburg 		Biochemical and Biophysical Research Communications 1998
TGF-β: A Link Between Immunosuppression, Nephrotoxicity, and CsA
AK Khanna, VR Cairns, CG Becker, JD Hosenpud 		Transplantation Proceedings 1998
Early induction of transforming growth factor-beta via angiotensin II type 1 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats
H Tomita, K Egashira, Y Ohara, M Takemoto, M Koyanagi, M Katoh, H Yamamoto, K Tamaki, H Shimokawa, A Takeshita 		Hypertension 1998
Cytokine interactions promote synergistic fibronectin accumulation by mesangial cells
IZ Pawluczyk, KP Harris 		Kidney International 1998
Transforming growth factor-β1 hyperexpression in African American end-stage renal disease patients
M Suthanthiran, A Khanna, D Cukran, R Adhikarla, VK Sharma, T Singh, P August 		Kidney International 1998
Applied Pressure Enhances Cell Proliferation through Mitogen-activated Protein Kinase Activation in Mesangial Cells
Y Kawata, Y Mizukami, Z Fujii, T Sakumura, K Yoshida, M Matsuzaki 		The Journal of biological chemistry 1998
Dietary salt enhances glomerular endothelial nitric oxide synthase through TGF-β1
WZ Ying, PW Sanders 		American journal of physiology. Renal physiology 1998
Regulation of human mesangial cell collagen expression by transforming growth factor-β1
AC Poncelet, HW Schnaper 		American journal of physiology. Renal physiology 1998
Dietary salt modulates renal production of transforming growth factor-β in rats
WZ Ying, PW Sanders 		American journal of physiology. Renal physiology 1998
Effects of chronic inhibition of ACE and AT 1 receptors on glomerular injury in Dahl salt-sensitive rats
F Otsuka, T Yamauchi, H Kataoka, Y Mimura, T Ogura, H Makino 		American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 1998
Tumorerkrankungen
D Ganten, K Ruckpaul 		1998
In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat
K Suzuki, Y Sawa, Y Kaneda, H Ichikawa, R Shirakura, H Matsuda 		Journal of Clinical Investigation 1997
Tyrosine kinase dependent expression of TGF-β induced by stretch in mesangial cells
M Hirakata, S Kaname, UG Chung, N Joki, Y Hori, M Noda, Y Takuwa, T Okazaki, T Fujita, T Katoh, K Kurokawa 		Kidney International 1997
Cytokine, chemokine and growth factor expression in the pathogenesis of progressive renal damage
FP SCHENA, G GRANDALIANO, V MONTINARO, E RANIERI, R MONNO, L GESUALDO 		Nephrology 1997
TGF-β1-induced cell cycle arrest in renal mesangial cells involves inhibition of cyclin E-cdk 2 activation and retinoblastoma protein phosphorylation
HO Schoecklmann, HD Rupprecht, I Zauner, RB Sterzel 		Kidney International 1997
Oxidized LDL stimulates the expression of TGF-β and fibronectin in human glomerular epithelial cells
G Ding, HV Goor, SD Ricardo, JM Orlowski, JR Diamond 		Kidney International 1997
Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass
T Konta, N Degawa, S Kato, H Tomoike 		Clinical and Experimental Nephrology 1997
Anti-angiogenic compound (TNP-470) inhibits mesangial cell proliferation in vitro and in vivo
M Haraguchi, M Okamura, M Konishi, Y Konishi, N Negoro, T Inoue, Y Kanayama, J Yoshikawa 		Kidney International 1997
TGF-β in kidney fibrosis: A target for gene therapy
WA Border, NA Noble 		Kidney International 1997
Growth factor antagonists for the treatment of diabetic vascular complications
RG Tilton, RA Dixon, TA Brock 		Expert Opinion on Investigational Drugs 1997
Renal fibrosis: Insights into pathogenesis and treatment
AM Nahas, EC Muchaneta-Kubara, M Essaway, O Soylemezoglu 		The International Journal of Biochemistry & Cell Biology 1997
Strategic gene transfer into the kidney: Current status and prospects
M Kitamura 		Clinical and Experimental Nephrology 1997
Altered expression of fibrogenic growth factors in IgA nephropathy and focal and segmental glomerulosclerosis
AN Stein-Oakley, JA Maguire, J Dowling, G Perry, NM Thomson 		Kidney International 1997
Malignant pleural mesothelioma
HC Hoogsteden, AW Langerak, TH van der Kwast, MA Versnel, T Gelder 		Critical Reviews in Oncology/Hematology 1997
Development and Characterization of Cationic Liposomes Conjugated with HVJ (Sendai Virus): Reciprocal Effect of Cationic Lipid forIn VitroandIn VivoGene Transfer
Y Saeki, N Matsumoto, Y Nakano, M Mori, K Awai, Y Kaneda 		Human Gene Therapy 1997
Ribozyme-based gene cleavage approach to chronic arthritis associated with human T cell leukemia virus type I. Induction of apoptosis in synoviocytes by ablation of HTLV-I tax protein
I Kitajima, N Hanyu, K Kawahara, Y Soejima, I Maruyama, T Kubo, R Yamada, Y Kaneda 		Arthritis & Rheumatism 1997
Nonviral Gene Delivery to the Rat Kidney with Polyethylenimine
A Boletta, A Benigni, J Lutz, G Remuzzi, MR Soria, L Monaco 		Human Gene Therapy 1997
In Vivo Transfer of Foreign Gene to Keratinocytes Using the Hemagglutinating Virus of Japan-Liposome Method
D Sawamura, X Meng, S Ina, H Ishikawa, K Tamai, K Nomura, K Hanada, I Hashimoto, Y Kaneda 		Journal of Investigative Dermatology 1997
Temporal and spatial expression of transforming growth factor-? in the healing patellar ligament of the rat
T Natsuume, N Nakamura, K Shino, Y Toritsuka, S Horibe, T Ochi 		Journal of Orthopaedic Research 1997
New therapeutic strategies of molecular intervention in glomerulonephritis
E IMAI, Y ISAKA, Y AKAGI, Y ANDO, M ARAI, T KANEKO, M TAKENAKA, T MORIYAMA, A YAMAUCHI, M HORIO, A ANDO, Y ORITA, N UEDA 		Nephrology 1997
Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation
Z Xing, GM Tremblay, PJ Sime, J Gauldie 		The American Journal of Pathology 1997
Growth Factors and Cytokines in Health and Disease
P Martin, J McCluskey, P Mallucci, S Nodder 		Growth Factors and Cytokines in Health and Disease 1997
Transforming Growth Factor-β
DA Cox, T Maurer 		Clinical Immunology and Immunopathology 1997
Progression of renal damage in human glomerulonephritides: Is there sleight of hand in winning the game?
FP Schena, L Gesualdo, G Grandaliano, V Montinaro 		Kidney International 1997
Gene Transfer in the Cardiovascular System
KL March 		1997
Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS
WN Suki, SG Massry 		1997
Novel Methods in Molecular and Cellular Biochemistry of Muscle
GN Pierce, WC Claycomb 		1997
DNA transfer into vascular smooth muscle using fusigenic Sendai virus (HVJ)-liposomes
M J Mann, R Morishita, G H Gibbons, H E von der Leyen, V J Dzau 		Molecular and Cellular Biochemistry 1997
Transient introduction of a foreign gene into healing rat patellar ligament
N Nakamura, S Horibe, N Matsumoto, T Tomita, T Natsuume, Y Kaneda, K Shino, T Ochi 		Journal of Clinical Investigation 1996
Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells
T Yasuda, S Kondo, T Homma, RC Harris 		Journal of Clinical Investigation 1996
Cytokines, Growth Factors, and Other Inflammatory Mediators in Glomerulonephritis
A Papayianni 		Renal Failure 1996
Production of hyaluronan by glomerular mesangial cells in response to fibronectin and platelet-derived growth factor
ME Dunlop, S Clark, P Mahadevan, E Muggli, RG Larkins 		Kidney International 1996
Extracellular matrix, growth factors and their interactions in the pathogenesis of diabetic kidney disease
RE GILBERT, ME COOPER, G JERUMS 		Nephrology 1996
IMMUNOLOCALIZATION OF FGF-1 AND RECEPTORS IN GLOMERULAR LESIONS ASSOCIATED WITH CHRONIC HUMAN RENAL ALLOGRAFT REJECTION1
JD Kerby, DJ Verran, KL Luo, Q Ding, Y Tagouri, GA Herrera, AG Diethelm, JA Thompson 		Transplantation 1996
Involvement of oxidation in LDL-induced collagen gene regulation in mesangial cells
HS Lee, BC Kim, YS Kim, KH Choi, HK Chung 		Kidney International 1996
Transforming Growth Factor β in Diabetic Nephropathy
WA Border, T Yamamoto, NA Noble 		Diabetes/Metabolism Reviews 1996
Vasoactive hormones and renal sclerosis
J Egido 		Kidney International 1996
Experimental Glomerulosclerosis: Defektheilung of the Kidney
B Schiller, J Moran 		Artificial Organs 1996
Gene transfer into the kidney: Promise for unravelling disease mechanisms, limitations for human gene therapy
LG Fine 		Kidney International 1996
Quantification of glomerular TGF-β1 mRNA in patients with diabetes mellitus
M Iwano, A Kubo, T Nishino, H Sato, H Nishioka, Y Akai, H Kurioka, Y Fujii, M Kanauchi, H Shiiki, K Dohi 		Kidney International 1996
Interaction of native and oxidized lipoprotein(a) with human mesangial cells and matrix
A Krämer-Guth, S Greiber, H Pavenstädt, T Quaschning, K Winkler, P Schollmeyer, C Wanner 		Kidney International 1996
Inhibition of TGF-β1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis
Y Akagi, Y Isaka, M Arai, T Kaneko, M Takenaka, T Moriyama, Y Kaneda, A Ando, Y Orita, T Kamada, N Ueda, E Imai 		Kidney International 1996
Expression of transforming growth factor-β isoforms in human glomerular diseases
T Yamamoto, NA Noble, AH Cohen, CC Nast, A Hishida, LI Gold, WA Border 		Kidney International 1996
Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney
Y Isaka, DK Brees, K Ikegaya, Y Kaneda, E Imai, NA Noble, WA Border 		Nature Medicine 1996
Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats
V Kliem, RJ Johnson, CE Alpers, A Yoshimura, WG Couser, KM Koch, J Floege 		Kidney International 1996
Intragraft TGF-β1 mRNA: A correlate of interstitial fibrosis and chronic allograft nephropathy
VK Sharma, RM Bologa, GP Xu, B Li, J Mouradian, J Wang, D Serur, V Rao, M Suthanthiran 		Kidney International 1996
Characterization and regulation of the latent transforming growth factor-β complex secreted by vascular pericytes
F Marra, LF Bonewald, S Park-Snyder, IS Park, KA Woodruff, HE Abboud 		Journal of Cellular Physiology 1996
Apoptosis in glomerular sclerosis
H Sugiyama, N Kashihara, H Makino, Y Yamasaki, Z Ota 		Kidney International 1996
Molecular therapy for renal diseases
MS Lipkowitz, ME Klotman, LA Bruggeman, P Nicklin, B Hanss, J Rappaport, PE Klotman 		American Journal of Kidney Diseases 1996
Engineering, Expression and Renaturation of Targeted TGF-Beta Fusion Proteins
TL Tuan, DT Cheung, LT Wu, A Yee, S Gabriel, B Han, L Morton, ME Nimni, FL Hall 		Connective Tissue Research 1996
Regulation of platelet-derived growth factor isoform-mediated expression of prostaglandin G/H synthase in mesangial cells
M Goppelt-Struebe, M Stroebel, J Hoppe 		Kidney International 1996
In VivoGene Transfer and Expression in Rat Stomach by Submucosal Injection of Plasmid DNA
T Takehara, N Hayashi, M Yamamoto, Y Miyamoto, H Fusamoto, T Kamada 		Human Gene Therapy 1996
Cell-matrix interactions in the glomerular mesangium
HD Rupprecht, HO Schöcklmann, RB Sterzel 		Kidney International 1996
Cyclic stretching force selectively up-regulates transforming growth factor-beta isoforms in cultured rat mesangial cells
BL Riser, P Cortes, C Heilig, J Grondin, S Ladson-Wofford, D Patterson, RG Narins 		The American Journal of Pathology 1996
Reshaping the interstitium by platelet-derived growth factor. Implications for progressive renal disease
KA Nath 		The American Journal of Pathology 1996
Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis
WW Tang, TR Ulich, DL Lacey, DC Hill, M Qi, SA Kaufman, GY Van, JE Tarpley, JS Yee 		The American Journal of Pathology 1996
Macrophage growth factors introduced into the kidney initiate renal injury
T Naito, H Yokoyama, KJ Moore, G Dranoff, RC Mulligan, VR Kelley 		Molecular Medicine 1996
Creation of a reversible on/off system for site-specific in vivo control of exogenous gene activity in the renal glomerulus
M Kitamura 		Proceedings of the National Academy of Sciences 1996
PATHOGENESIS OF SCLERODERMA
SA Jimenez, E Hitraya, J Varga 		Rheumatic Disease Clinics of North America 1996
Trapidil modifies mesangial cell proliferation and collagen accumulation in anti-thymocyte serum (ATS)-induced glomerulonephritis
M Razzaque, M Cheng, T Taguchi 		Journal of Comparative Pathology 1996
Activation of a Nuclear DNA-binding Protein Recognized by a Transcriptional Element, bcn-1, from the Laminin B2 Chain Gene Promoter
H Suzuki, BC O'Neill, Y Suzuki, ON Denisenko, K Bomsztyk 		The Journal of biological chemistry 1996
Significance of Increased Accumulation of Type VI Collagen and Transforming Growth Factor βi in Tubulointerstitial Damage in Hypertensive Nephrosclerosis: An Immunohistochemical Study
MS Razzaque, T Harada, T Taguchi 		J INT MED RES 1996
MOLECULAR CONJUGATE-MEDIATED GENE TRANSFER INTO ISOLATED HUMAN KIDNEYS1:
ST Zeigler, JD Kerby, DT Curiel, AG Diethelm, JA Thompson 		Transplantation 1996
Interaction of transforming growth factor β1 with human glomerular epithelial cells in culture: opposite effects on synthesis of matrix proteins and on urokinase plasminogen activator
C Wagner, C Viedt, A Bürger, S Filsinger, M Kramer, GM Hänsch 		Journal of Molecular Medicine 1996
Regulation of rat mesangial cell growth by diadenosine phosphates
S Heidenreich, M Tepel, H Schlüter, B Harrach, W Zidek 		Journal of Clinical Investigation 1995
In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer
T Yamada, M Horiuchi, R Morishita, L Zhang, RE Pratt, VJ Dzau 		Journal of Clinical Investigation 1995
Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype
CW Heilig, LA Concepcion, BL Riser, SO Freytag, M Zhu, P Cortes 		Journal of Clinical Investigation 1995
Role of platelets in progressive glomerular diseases
C Zoja, G Remuzzi 		Pediatric Nephrology 1995
Therapeutic uses for neural grafts: Progress slowed but not abandoned
RH Baisden 		Behavioral and Brain Sciences 1995
Multiple obstacles to gene therapy in the brain
DA Sanders 		Behavioral and Brain Sciences 1995
Studying restoration of brain function with fetal tissue grafts: Optimal models
R Silver, J LeSauter 		Behavioral and Brain Sciences 1995
Transplantation, plasticity, and the aging host
DL Felten 		Behavioral and Brain Sciences 1995
Lessons on transplant survival from a successful model system
SB Moffett 		Behavioral and Brain Sciences 1995
Pathway rewiring with neural transplantation
P Strata, F Rossi 		Behavioral and Brain Sciences 1995
Will brain tissue grafts become an important therapy to restore visual function in cerebrally blind patients?
R Werth 		Behavioral and Brain Sciences 1995
Repairing the brain: Trophic factor or transplant?
NW Bond 		Behavioral and Brain Sciences 1995
Models of neurological defects and defects in neurological models
T Schallert 		Behavioral and Brain Sciences 1995
Difficulties inherent in the restoration of dynamically reactive brain systems
BB Stanfield 		Behavioral and Brain Sciences 1995
Thinking about repairing thinking
RM Ridley 		Behavioral and Brain Sciences 1995
Local and global gene therapy in the central nervous system
LL Muldoon, EA Neuwelt 		Behavioral and Brain Sciences 1995
Grafts and the art of mind's reconstruction
JD Sinden, H Hodges, JA Gray 		Behavioral and Brain Sciences 1995
Neural grafting in human disease versus animal models: Cautionary notes
K Steece-Collier 		Behavioral and Brain Sciences 1995
The ethics of fetal tissue grafting should be considered along with the science
KA Crutcher 		Behavioral and Brain Sciences 1995
Principles of brain tissue engineering
WJ Freed, TD Smith 		Behavioral and Brain Sciences 1995
Gene replacement therapy in the CNS: A view from the retina
GM Seigel 		Behavioral and Brain Sciences 1995
Gene therapy and neural grafting: Keeping the message switched on
CN Svendsen, SB Dunnett 		Behavioral and Brain Sciences 1995
Multiple potential mechanisms of graft action is not a new idea
SB Dunnett 		Behavioral and Brain Sciences 1995
Gene therapy for neurodegenerative disorders and malignant brain tumors
L Chiang, EP Flores, DY Wen, WA Hall, WC Low 		Behavioral and Brain Sciences 1995
Elegant studies of transplant-derived repair of cognitive performance
SB Dunnett, EM Torres 		Behavioral and Brain Sciences 1995
The spinal cord as an alternative model for nerve tissue graft
A Privat, MG Ribotta 		Behavioral and Brain Sciences 1995
Some practical and theoretical issues concerning fetal brain tissue grafts as therapy for brain dysfunctions
DG Stein, MM Glasier 		Behavioral and Brain Sciences 1995
Neural transplantation, cognitive aging and speech
MP Lynch 		Behavioral and Brain Sciences 1995
Immunobiology of neural transplants and functional incorporation of grafted dopamine neurons
JB Blount, T Kondoh, LL Pundt, J Conrad, EM Jansen, WC Low 		Behavioral and Brain Sciences 1995
Building a rational foundation for neural transplantation
HP Davis, BT Volpe 		Behavioral and Brain Sciences 1995
Intraretrosplenial grafts of cholinergic neurons and spatial memory function
YJ Li, WC Low 		Behavioral and Brain Sciences 1995
The structure, operation, and functionality of intracerebral grafts
JC Cassel, B Will 		Behavioral and Brain Sciences 1995
CNS transplant utility may surive even their hasty clinical application
M Nieto-Sampedro 		Behavioral and Brain Sciences 1995
Behavioral effects of neural grafts: Action still in search of a mechanism
ML Woodruff 		Behavioral and Brain Sciences 1995
Therapeutic neural transplantation: Boon or boondoggle?
JH Haring 		Behavioral and Brain Sciences 1995
Are fetal brain tissue grafts necessary for the treatment of brain damage?
DG Stein, MM Glasier 		Behavioral and Brain Sciences 1995
The NGF superfamily of neurotrophins: Potential treatment for Alzheimer's and Parkinson's disease
EJ Mufson, T Sobreviela 		Behavioral and Brain Sciences 1995
The limitations of central nervous systemdirected gene transfer
BL Davidson 		Behavioral and Brain Sciences 1995
Neural transplants are grey matters
B Anderson, A Chatterjee, G Graham 		Behavioral and Brain Sciences 1995
Section Review: Cardiovascular & Renal: Angiotensin converting enzyme inhibitors and nephroprotection
E Franek, D Fliser, E Ritz 		Expert Opinion on Investigational Drugs 1995
Protein kinase C signals thromboxane induced increases in fibronectin synthesis and TGF-β bioactivity in mesangial cells
RK Studer, H Negrete, PA Craven, FR DeRubertis 		Kidney International 1995
Transfer of a mutated gene encoding active transforming growth factor-β1 suppresses mitogenesis and IL-1 response in the glomerulus
M Kitamura, S Burton, J English, H Kawachi, LG Fine 		Kidney International 1995
PDGF and TGF-β contribute to the natural course of human IgA glomerulonephritis
ZI Niemir, H Stein, IL Noronha, C Krüger, K Andrassy, E Ritz, R Waldherr 		Kidney International 1995
Matrix protein synthesis by glomerular mesangial cells in culture: Effects of transforming growth factor ? (TGF?) and platelet-derived growth factor (PDGF) on fibronectin and collagen type IV mRNA
GM H�nsch, C Wagner, A B�rger, W Dong, G Staehler, M Stoeck 		Journal of Cellular Physiology 1995
Progressive renal lesions induced by administration of monoclonal antibody 1-22-3 to unilaterally nephrectomized rats
Q Cheng, M Orikasa, T Morioka, H Kawachi, X Chen, T Oite, F Shimizu 		Clinical & Experimental Immunology 1995
Cyclosporine enhances the expression of TGF-β in the juxtaglomerular cells of the rat kidney
M Shehata, GH Cope, TS Johnson, AT Raftery, AM el Nahas 		Kidney International 1995
Early glomerular changes in rats with dietary-induced hypercholesterolemia
C Guijarro, BL Kasiske, Y Kim, MP O'Donnell, HS Lee, WF Keane 		American Journal of Kidney Diseases 1995
Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria
AA Eddy, CM Giachelli, L McCulloch, E Liu 		Kidney International 1995
Effects of glycosaminoglycans on the glomerular changes induced by Adriamycin
F Pieroni, RS Costa, TM Coimbra 		Research in Experimental Medicine 1995
Pathogenesis of glomerulosclerosis in light chain deposition disease. Role for transforming growth factor-beta
L Zhu, GA Herrera, JE Murphy-Ullrich, ZQ Huang, PW Sanders 		The American Journal of Pathology 1995
L-arginine may mediate the therapeutic effects of low protein diets
I Narita, WA Border, M Ketteler, E Ruoslahti, NA Noble 		Proceedings of the National Academy of Sciences 1995
A histologically distinctive interstitial pneumonia induced by overexpression of the interleukin 6, transforming growth factor beta 1, or platelet-derived growth factor B gene
M Yoshida, J Sakuma, S Hayashi, K Abe, I Saito, S Harada, M Sakatani, S Yamamoto, N Matsumoto, Y Kaneda 		Proceedings of the National Academy of Sciences 1995
Intervention in diabetic vascular disease by modulation of growth factors
O Serri, G Renier 		Metabolism 1995
Synthesis of type III Collagen and type IV collagen by tubular epithelial cells in diabetic nephropathy
MS Razzaque, T Koji, Y Horita, M Nishihara, T Harada, PK Nakane, T Taguchi 		Pathology - Research and Practice 1995
Protein kinase C in diabetic nephropathy
PA Craven, RK Studer, H Negrete, FR DeRubertis 		Journal of Diabetes and its Complications 1995
Synergistic induction of monocyte chemoattractant protein-1 (MCP-1) by platelet-derived growth factor and interleukin-1
M Goppelt-Struebe, M Stroebel 		FEBS Letters 1995
Suppression of Mesangial-Cell Proliferation by Trapidil in Glomerulonephritis Induced by Anti-Thymocyte Serum in Rats
MS Razzaque, M Cheng, T Taguchi 		J INT MED RES 1995
Molecular and Cell Biology of Human Gene Therapeutics
G Dickson 		1995
Transforming Growth Factor-β1 Expression and Phenotypic Modulation in the Kidney of Hypertensive Rats
A Hamaguchi, S Kim, K Ohta, K Yagi, T Yukimura, K Miura, T Fukuda, H Iwao 		Hypertension 1995
Interventionen am Herzen
F Unger, H Mörl, HA Dieterich 		1995
Progressive renal lesions induced by administration of monoclonal antibody 1-22-3 to unilaterally nephrectomized rats.
Cheng QL, Orikasa M, Morioka T, Kawachi H, Chen XM, Oite T, Shimizu F 		Clinical & Experimental Immunology 1995
Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells
S Kagami, WA Border, DE Miller, NA Noble 		Journal of Clinical Investigation 1994
Gene transfer into the rat renal glomerulus via a mesangial cell vector: site-specific delivery, in situ amplification, and sustained expression of an exogenous gene in vivo
M Kitamura, S Taylor, R Unwin, S Burton, F Shimizu, LG Fine 		Journal of Clinical Investigation 1994
Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis
AJ Baker, A Mooney, J Hughes, D Lombardi, RJ Johnson, J Savill 		Journal of Clinical Investigation 1994
The glomerular response to injury: Progression or resolution?
RJ Johnson 		Kidney International 1994
Cellular Biology of Glomerulosclerosis
EN Wardie 		Renal Failure 1994
Intraglomerular expression of transforming growth factor-beta 1 (TGF-β1) mRNA in patients with glomerulonephritis: quantitative analysis by competitive polymerase chain reaction
M Iwano, Y Akai, Y Fujii, Y Dohi, N Matsumura, K Dohi 		Clinical & Experimental Immunology 1994
Contribution of renal angiotensin II type I receptor to gene expressions in hypertension-induced renal injury
S Kim, K Ohta, A Hamaguchi, T Omura, T Yukimura, K Miura, Y Inada, T Wada, Y Ishimura, F Chatani, H Iwao 		Kidney International 1994
Lipids and the kidney
WF Keane 		Kidney International 1994
Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis
AJ Baker, A Mooney, J Hughes, D Lombardi, RJ Johnson, J Savill 		Experimental Cell Research 1994
Intraglomerular expression of transforming growth factor-beta 1 (TGF-beta 1) mRNA in patients with glomerulonephritis: quantitative analysis by competitive polymerase chain reaction
M Iwano, Y Akai, Y Fujii, Y Dohi, N Matsumura, K Dohi 		Clinical & Experimental Immunology 1994
Gene transfer for transplantation. Prolongation of allograft survival with transforming growth factor-beta 1
L Qin, KD Chavin, Y Ding, JE Woodward, JP Favaro, J Lin, JS Bromberg 		Annals of Surgery 1994
Transforming growth factor β2 stimulates acute and chronic activation of the mitogen-activated protein kinase cascade in rat renal mesangial cells
A Huwiler, J Pfeilschifter 		FEBS Letters 1994
Cell Biology
Y Kaneda 		The Journal of Cell Biology 1994
Increased glomerular capillary pressure alters glomerular cytokine expression
SJ Shankland, H Ly, K Thai, JW Scholey 		Circulation research 1994
Inflammation and glomerular injury
A Benigni, G Remuzzi 		Springer Seminars in Immunopathology 1994
Bone Marrow Transplantation
R Champlin 		Bone Marrow Transplantation 1990
The Molecular and Cellular Biology of Wound Repair
RA Clark, PM Henson 		1988

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