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Citations to this article

Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens.
D Y Leung, … , J M Hanifin, H A Sampson
D Y Leung, … , J M Hanifin, H A Sampson
Published September 1, 1993
Citation Information: J Clin Invest. 1993;92(3):1374-1380. https://doi.org/10.1172/JCI116711.
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Research Article Article has an altmetric score of 12

Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens.

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Abstract

In the current study, we investigated whether Staphylococcus aureus grown from affected skin of atopic dermatitis (AD) patients secreted identifiable toxins that could act as allergens to induce IgE-mediated basophil histamine release. The secreted toxins of S. aureus grown from AD patients were identified by ELISA using antibodies specific for staphylococcal enterotoxin (SE) exfoliative toxin (ET), or toxic shock syndrome toxin (TSST-1). S. aureus isolates from 24 of 42 AD patients secreted identifiable toxins with SEA, SEB, and TSST accounting for 92% of the isolates. 32 of 56 AD sera (57%) tested contained significant levels of IgE primarily to SEA, SEB, and/or TSST. In contrast, although SEA, SEB, or TSST secreting S. aureus could be recovered from the skin of psoriasis patients, their sera did not contain IgE antitoxins. Freshly isolated basophils from 10 AD patients released 5-59% of total histamine in response to SEA, SEB, or TSST-1 but only with toxins to which patients had specific IgE. Basophils from eight other AD patients and six normal controls who had no IgE antitoxin failed to demonstrate toxin-induced basophil histamine release. Stripped basophils sensitized with three AD sera containing IgE to toxin released 15-41% of total basophil histamine only when exposed to the relevant toxin, but not to other toxins. Sensitization of basophils with AD sera lacking IgE antitoxin did not result in release of histamine to any of the toxins tested. These data indicate that a subset of patients with AD mount an IgE response to SEs that can be grown from their skin. These toxins may exacerbate AD by activating mast cells, basophils, and/or other Fc epsilon-receptor bearing cells armed with the relevant IgE antitoxin.

Authors

D Y Leung, R Harbeck, P Bina, R F Reiser, E Yang, D A Norris, J M Hanifin, H A Sampson

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1989 1987 1984 Total
Citations: 4 4 7 7 9 9 9 14 11 4 12 15 8 9 17 25 15 13 18 19 13 10 16 18 20 22 16 11 10 9 3 1 1 1 1 381
Citation information
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Citations to this article in year 2018 (9)

Title and authors Publication Year
The prevalence of antibody responses against Staphylococcus aureus antigens in patients with atopic dermatitis: a systematic review and meta-analysis
J de Wit, JE Totté, FJ van Buchem, SG Pasmans
British Journal of Dermatology 2018
In chronic spontaneous urticaria, IgE against staphylococcal enterotoxins is common and functional
S Altrichter, T Hawro, M Liedtke, G Holtappels, C Bachert, PS Skov, M Maurer
Allergy 2018
Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration
H Baurecht, MC Rühlemann, E Rodríguez, F Thielking, I Harder, AS Erkens, D Stölzl, E Ellinghaus, M Hotze, W Lieb, S Wang, FA Heinsen-Groth, A Franke, S Weidinger
Journal of Allergy and Clinical Immunology 2018
T helper type 2 signatures in atopic dermatitis
M Furue
2018
The quest for bacterial allergens
M Nordengrün, S Michalik, U Völker, BM Bröker, L Gómez-Gascón
International journal of medical microbiology : IJMM 2018
Effect of atopic skin stressors on natural moisturizing factors and cytokines in healthy adult epidermis
KA Engebretsen, S Kezic, I Jakasa, A Hedengran, A Linneberg, L Skov, JD Johansen, JP Thyssen
British Journal of Dermatology 2018
The impact of lifestyle factors on evolution of atopic dermatitis: An alternative approach (Review)
I Solomon, M Ilie, C Draghici, V Voiculescu, C Căruntu, D Boda, S Zurac
Experimental and therapeutic medicine 2018
Role of Superantigens in Allergic Inflammation: Their Relationship to Allergic Rhinitis, Chronic Rhinosinusitis, Asthma, and Atopic Dermatitis
NB Muluk, F Altın, C Cingi
American journal of rhinology & allergy 2018
Antibiotic choice and methicillin-resistant Staphylococcus aureus rate in children hospitalized for atopic dermatitis
V Wang, M Keefer, PY Ong
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2018

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Referenced in 7 patents
Referenced in 2 clinical guideline sources
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