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Citations to this article

Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens.
D Y Leung, … , J M Hanifin, H A Sampson
D Y Leung, … , J M Hanifin, H A Sampson
Published September 1, 1993
Citation Information: J Clin Invest. 1993;92(3):1374-1380. https://doi.org/10.1172/JCI116711.
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Research Article Article has an altmetric score of 12

Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens.

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Abstract

In the current study, we investigated whether Staphylococcus aureus grown from affected skin of atopic dermatitis (AD) patients secreted identifiable toxins that could act as allergens to induce IgE-mediated basophil histamine release. The secreted toxins of S. aureus grown from AD patients were identified by ELISA using antibodies specific for staphylococcal enterotoxin (SE) exfoliative toxin (ET), or toxic shock syndrome toxin (TSST-1). S. aureus isolates from 24 of 42 AD patients secreted identifiable toxins with SEA, SEB, and TSST accounting for 92% of the isolates. 32 of 56 AD sera (57%) tested contained significant levels of IgE primarily to SEA, SEB, and/or TSST. In contrast, although SEA, SEB, or TSST secreting S. aureus could be recovered from the skin of psoriasis patients, their sera did not contain IgE antitoxins. Freshly isolated basophils from 10 AD patients released 5-59% of total histamine in response to SEA, SEB, or TSST-1 but only with toxins to which patients had specific IgE. Basophils from eight other AD patients and six normal controls who had no IgE antitoxin failed to demonstrate toxin-induced basophil histamine release. Stripped basophils sensitized with three AD sera containing IgE to toxin released 15-41% of total basophil histamine only when exposed to the relevant toxin, but not to other toxins. Sensitization of basophils with AD sera lacking IgE antitoxin did not result in release of histamine to any of the toxins tested. These data indicate that a subset of patients with AD mount an IgE response to SEs that can be grown from their skin. These toxins may exacerbate AD by activating mast cells, basophils, and/or other Fc epsilon-receptor bearing cells armed with the relevant IgE antitoxin.

Authors

D Y Leung, R Harbeck, P Bina, R F Reiser, E Yang, D A Norris, J M Hanifin, H A Sampson

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1989 1987 1984 Total
Citations: 4 4 7 7 9 9 9 14 11 4 12 15 8 9 17 25 15 13 18 19 13 10 16 18 20 22 16 11 10 9 3 1 1 1 1 381
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Citations to this article in year 2017 (14)

Title and authors Publication Year
The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and pruritus
P Rerknimitr, A Otsuka, C Nakashima, K Kabashima
Inflammation and Regeneration 2017
Middleton's Allergy Essentials
ST Holgate, M Thomas
Middleton's Allergy Essentials 2017
Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies
M Furue, T Chiba, G Tsuji, D Ulzii, M Kido-Nakahara, T Nakahara, T Kadono
Allergology International 2017
Clinical and Basic Immunodermatology
AA Gaspari, SK Tyring, DH Kaplan
Clinical and Basic Immunodermatology 2017
The complex biology and contribution of Staphylococcus aureus in atopic dermatitis, current and future therapies
L Hepburn, DJ Hijnen, BR Sellman, T Mustelin, MA Sleeman, RD May, I Strickland
The British journal of dermatology 2017
Formulation and development of Silybin loaded solid lipid nanoparticle enriched gel for irritant contact dermatitis
SN Shrotriya, BV Vidhate, MS Shukla
Journal of drug delivery science and technology 2017
Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship
JA Geoghegan, AD Irvine, TJ Foster
Trends in Microbiology 2017
Dermatology in Public Health Environments
RR Bonamigo, SI Dornelles
Dermatology in Public Health Environments 2017
House dust mites as potential carriers for IgE sensitization to bacterial antigens
S Dzoro, I Mittermann, Y Resch-Marat, S Vrtala, M Nehr, AM Hirschl, G Wikberg, L Lundeberg, C Johansson, A Scheynius, R Valenta
Allergy 2017
Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps
JB Chen, LK James, AM Davies, YC Wu, J Rimmer, VJ Lund, JH Chen, JM McDonnell, YC Chan, GH Hutchins, TW Chang, BJ Sutton, HH Kariyawasam, HJ Gould
Journal of Allergy and Clinical Immunology 2017
Colonization of Staphylococcus aureus and sensitivity to antibiotics in children with atopic dermatitis
Y Hwang, JS Kang, BK Kim, SW Kim
Allergy Asthma & Respiratory Disease 2017
Skin and allergy
Y Ohya
Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunollogy 2017
Infectious Complications in Atopic Dermatitis
D Sun, PY Ong
Immunology and Allergy Clinics of North America 2017
Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy
P Meylan, C Lang, S Mermoud, A Johannsen, S Norrenberg, D Hohl, Y Vial, G Prodhom, G Greub, M Kypriotou, S Christen-Zaech
Journal of Investigative Dermatology 2017

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Referenced in 7 patents
Referenced in 2 clinical guideline sources
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