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Citations to this article

Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.
R Donghi, … , G Della Porta, M A Pierotti
R Donghi, … , G Della Porta, M A Pierotti
Published April 1, 1993
Citation Information: J Clin Invest. 1993;91(4):1753-1760. https://doi.org/10.1172/JCI116385.
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Research Article Article has an altmetric score of 13

Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.

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Abstract

The p53 gene was analyzed in tumor specimens obtained from 52 patients with various types of carcinoma of the thyroid gland by a combined molecular and immunocytochemical approach. The histologic types included 37 well-differentiated papillary and follicular carcinomas, 8 poorly differentiated, and 7 undifferentiated carcinomas. The p53 gene was shown to be unaffected in all differentiated tumors by single-strand conformation polymorphism analysis. However, in two out of eight (25%) of poorly differentiated carcinomas and five out of seven (71%) undifferentiated carcinomas, p53 mutations were identified and subsequently characterized by DNA sequencing. One undifferentiated carcinoma displayed two areas with varying degrees of differentiation. The comparative analysis of the p53 gene, in both the more and the less differentiated area of this tumor, clearly showed that the p53 mutation was confined to the latter component of the tumor specimen. These results indicate that mutations of the p53 gene are associated with the most aggressive histologic types of thyroid tumors, such as the undifferentiated carcinoma and, to a certain extent, the poorly differentiated carcinoma, and that the alterations of this gene represent a late genetic event in human thyroid carcinogenesis.

Authors

R Donghi, A Longoni, S Pilotti, P Michieli, G Della Porta, M A Pierotti

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Citations to this article in year 2017 (13)

Title and authors Publication Year
Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies
E Molinaro, C Romei, A Biagini, E Sabini, L Agate, S Mazzeo, G Materazzi, S Sellari-Franceschini, A Ribechini, L Torregrossa, F Basolo, P Vitti, R Elisei
Nature Reviews Endocrinology 2017
ZCCHC12, a novel oncogene in papillary thyroid cancer
O Wang, Z Zheng, Q Wang, Y Jin, W Jin, Y Wang, E Chen, X Zhang
Journal of Cancer Research and Clinical Oncology 2017
Diagnostic Molecular Pathology
RC Arcenas
Diagnostic Molecular Pathology 2017
Molecular Pathology of Anaplastic Thyroid Carcinomas: A Retrospective Study of 144 Cases
B Bonhomme, Y Godbert, G Perot, AA Ghuzlan, S Bardet, G Belleannée, L Crinière, CD Cao, G Fouilloux, S Guyetant, A Kelly, S Leboulleux, C Buffet, E Leteurtre, JJ Michels, F Tissier, ME Toubert, M Wassef, C Pinard, I Hostein, I Soubeyran
Thyroid 2017
Oncogenesis of Thyroid Cancer
Enas Younis
Asian Pacific Journal of Cancer Prevention 2017
Thyroid and Parathyroid Ultrasound and Ultrasound-Guided FNA
DS Duick, RA Levine, MA Lupo
Thyroid and Parathyroid Ultrasound and Ultrasound-Guided FNA 2017
Molecular pathology of thyroid tumours of follicular cells: a review of genetic alterations and their clinicopathological relevance
G Acquaviva, M Visani, A Repaci, KJ Rhoden, D Biase, A Pession, T Giovanni
Histopathology 2017
Rare Manifestations of Anaplastic Thyroid Carcinoma: the Role of BRAF Mutation Analysis
YS Song, CK Jung, KC Jung, YJ Park, JK Won
Journal of Korean Medical Science 2017
Clear Cell Change in Thyroid Carcinoma: A Clinicopathologic and Molecular Study with Identification of Variable Genetic Anomalies
NA Cipriani, S Agarwal, D Dias-Santagata, WC Faquin, PM Sadow
Thyroid 2017
The interplay between histone deacetylases and rho kinases is important for cancer and neurodegeneration
S Mertsch, OH Krämer
Cytokine & Growth Factor Reviews 2017
Glycolysis-related protein expression in thyroid cancer
JH Nahm, HM Kim, JS Koo
Tumor Biology 2017
New perspectives in the diagnosis of thyroid follicular lesions
E Baldini, S Sorrenti, F Tartaglia, A Catania, A Palmieri, D Pironi, A Filippini, S Ulisse
International journal of surgery (London, England) 2017
Gene master regulators of papillary and anaplastic thyroid cancers
DA Iacobas, NY Tuli, S Iacobas, JK Rasamny, A Moscatello, J Geliebter, RK Tiwari
Oncotarget 2017

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