Interleukin-12 is a recently discovered lymphokine displaying an array of in vitro activities suggesting a major role in protective immunity against infectious agents like viruses. This study provides evidence that IL-12 may also be implicated in the selection of the immunoglobulin isotypes. We show that picomolar concentrations of rIL-12 markedly inhibit the synthesis of IgE by IL-4-stimulated PBMC. The suppression of IgE is observed at the protein and at the mRNA levels, it is isotype specific, and it is abolished by neutralizing anti-IL-12 mAbs. IL-12 may suppress IgE synthesis by: (a) inducing the production of IFN-gamma, a known inhibitor of IgE synthesis and (b) by a novel mechanism which is IFN-gamma independent. The best evidence for this is from studies on IgE synthesis by IL-4-plus hydrocortisone-stimulated umbilical cord blood lymphocytes, which do not produce detectable amounts of IFN-gamma. In such cultures, rIL-12 inhibits IgE synthesis even in the presence of a large excess of neutralizing anti-IFN-gamma mAb.
M Kiniwa, M Gately, U Gubler, R Chizzonite, C Fargeas, G Delespesse
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Research in Immunology | 1995 |
Interleukin-12 Synergizes With Interleukin-2 to Generate Lymphokine-Activated Killer Activity in Peripheral Blood Mononuclear Cells Cultured in Ovarian Cancer Ascitic Fluid
DP Barton, DK Blanchard, C Duan, WS Roberts, D Cavanagh, S DeCesare, JY Djeu |
Journal of the Society for Gynecologic Investigation | 1995 |
Cytokines: Interleukins and Their Receptors
R Kurzrock, M Talpaz |
1995 | |
Dual action of IL-4 on mite antigen-induced IgE synthesis in lymphocytes from individuals with bronchial asthma.
Kawano Y, Noma T |
Clinical & Experimental Immunology | 1995 |
Recombinant soluble form of the human high-affinity immunoglobulin E (IgE) receptor inhibits IgE production through its specific binding to IgE-bearing B cells
Y Yanagihara, K Kajiwara, K Ikizawa, T Koshio, K Okumura, C Ra |
Journal of Clinical Investigation | 1994 |
Interleukin-12: A bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency
J Chehimi, G Trinchieri |
Journal of Clinical Immunology | 1994 |
Interleukin 12: A key modulator of immune function
SF Wolf, D Sieburth, J Sypek |
Stem Cells | 1994 |
Cytokines in the generation of immune responses to, and resolution of, virus infection
CA Biron |
Current Opinion in Immunology | 1994 |
Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells
J Punnonen, G Aversa, BG Cocks, JE Vries |
Allergy | 1994 |
Does Atopic Dermatitis Result from Cytokine Dysregulation?
P Dupuy |
Journal of Investigative Dermatology | 1994 |
A reasonable Approach for the Treatment of HIV Infection in the Early Phase with Ozonetherapy (Autohaemotherapy). How 'Inflammatory' Cytokines may have A therapeutic Role
V Bocci |
Mediators of Inflammation | 1994 |
Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites
FD Finkelman, KB Madden, AW Cheever, IM Katona, SC Morris, MK Gately, BR Hubbard, WC Gause, JF Urban |
Journal of Experimental Medicine | 1994 |
Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis
KV Clemons, E Brummer, DA Stevens |
Antimicrobial agents and chemotherapy | 1994 |
Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection
SL Reiner, S Zheng, ZE Wang, L Stowring, RM Locksley |
Journal of Experimental Medicine | 1994 |
La participation des cytokines au cours des mécanismes allergiques
JM Cavaillon |
Immuno-analyse & Biologie Spécialisée | 1994 |
Humoral immunity in aging
R Paganelli, E Scala, I Quinti, IJ Ansotegui |
Aging clinical and experimental research | 1994 |
Interleukin 12 and the regulation of CD4+ T-cell subset responses during murine Leishmaniasis
FP Heinzel |
Parasitology Today | 1994 |
Mechanisms of the Human Allergic Response: Clinical Implications
DY Leung |
Pediatric Clinics of North America | 1994 |
Observations on the Response of the Nasal Mucosa to Allergens
RM Naclerio, FM Baroody |
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery | 1994 |
The importance of Th2-like cells in the pathogenesis of airway allergic inflammation
M Ricci, O Rossi, M Bertoni, A Matucci |
Clinical & Experimental Allergy | 1993 |
The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer
F Mattner, S Fischer, S Guckes, S Jin, H Kaulen, E Schmitt, E Rüde, T Germann |
European Journal of Immunology | 1993 |
Interleukin-12: A Recently Discovered Cytokine with Potential for Enhancing Cell-Mediated Immune Responses to Tumors
MK Gately |
Cancer Investigation | 1993 |
Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells
J Punnonen, G Aversa, BG Cocks, AN McKenzie, S Menon, G Zurawski, RW Malefyt, JE de Vries |
Proceedings of the National Academy of Sciences | 1993 |
The cytokine wall chart
F Burke, MS Naylor, B Davies, F Balkwill |
Immunology Today | 1993 |
Cytokines. 3. Cytokines in asthma
DS Robinson, SR Durham, AB Kay |
Thorax | 1993 |
The biological and clinical significance of helper T-cell subsets in the human
KM Müller, C Hauser |
Experimental Dermatology | 1992 |
Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation
G Trinchieri, M Wysocka, A D'Andrea, M Rengaraju, M Aste-Amezaga, M Kubin, NM Valiante, J Chehimi |
Progress in Growth Factor Research | 1992 |
Teil I: Referate
J Berendes, E Lehnhardt |
1983 |