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Citations to this article

Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes.
M Kiniwa, … , C Fargeas, G Delespesse
M Kiniwa, … , C Fargeas, G Delespesse
Published July 1, 1992
Citation Information: J Clin Invest. 1992;90(1):262-266. https://doi.org/10.1172/JCI115846.
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Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes.

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Abstract

Interleukin-12 is a recently discovered lymphokine displaying an array of in vitro activities suggesting a major role in protective immunity against infectious agents like viruses. This study provides evidence that IL-12 may also be implicated in the selection of the immunoglobulin isotypes. We show that picomolar concentrations of rIL-12 markedly inhibit the synthesis of IgE by IL-4-stimulated PBMC. The suppression of IgE is observed at the protein and at the mRNA levels, it is isotype specific, and it is abolished by neutralizing anti-IL-12 mAbs. IL-12 may suppress IgE synthesis by: (a) inducing the production of IFN-gamma, a known inhibitor of IgE synthesis and (b) by a novel mechanism which is IFN-gamma independent. The best evidence for this is from studies on IgE synthesis by IL-4-plus hydrocortisone-stimulated umbilical cord blood lymphocytes, which do not produce detectable amounts of IFN-gamma. In such cultures, rIL-12 inhibits IgE synthesis even in the presence of a large excess of neutralizing anti-IFN-gamma mAb.

Authors

M Kiniwa, M Gately, U Gubler, R Chizzonite, C Fargeas, G Delespesse

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Journal of Interferon & Cytokine Research 1995
Role of interferons and other cytokines in the regulation of the immune response
FI Belardelli
APMIS 1995
Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice
SH Gavett, DJ O'Hearn, X Li, SK Huang, FD Finkelman, M Wills-Karp
Journal of Experimental Medicine 1995
Modulation of mite antigen-induced immune responses by lecithin-bound iodine in peripheral blood lymphocytes from patients with bronchial asthma
Y Kawano, T Noma
British Journal of Pharmacology 1995
Interleukin 12: a new clinical player in cytokine therapy
RE Banks, PM Patel, PJ Selby
British Journal of Cancer 1995
Role of a carboxy-terminal site of toxic shock syndrome toxin 1 in eliciting immune responses of human peripheral blood mononuclear cells
A Drynda, B König, PF Bonventre, W König
Infection and immunity 1995
Signal sorting by G-protein-linked receptors
G Milligan
Advances in pharmacology (San Diego, Calif.) 1995
Immunopharmacology of Respiratory System
C Robinson
Immunopharmacology of Respiratory System 1995
The role of endogenous IL 12 in the induction of Th1-cell-mediated autoimmune diseases
L Adorini, J Magram, S Trembeau
Research in Immunology 1995
The influence of IL12 on the development of Th11 and Th2 cells and its adjuvant effect for humoral immune responses
T Germann, E Rüde, E Schmitt
Research in Immunology 1995
The effects of IL12 on B-cell subset function
DW Metzger, LA Vogel, VH Cleave, TL Lester, JM Buchanan
Research in Immunology 1995
Interleukin-12 Synergizes With Interleukin-2 to Generate Lymphokine-Activated Killer Activity in Peripheral Blood Mononuclear Cells Cultured in Ovarian Cancer Ascitic Fluid
DP Barton, DK Blanchard, C Duan, WS Roberts, D Cavanagh, S DeCesare, JY Djeu
Journal of the Society for Gynecologic Investigation 1995
Cytokines: Interleukins and Their Receptors
R Kurzrock, M Talpaz
1995
Dual action of IL-4 on mite antigen-induced IgE synthesis in lymphocytes from individuals with bronchial asthma.
Kawano Y, Noma T
Clinical & Experimental Immunology 1995
Recombinant soluble form of the human high-affinity immunoglobulin E (IgE) receptor inhibits IgE production through its specific binding to IgE-bearing B cells
Y Yanagihara, K Kajiwara, K Ikizawa, T Koshio, K Okumura, C Ra
Journal of Clinical Investigation 1994
Interleukin-12: A bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency
J Chehimi, G Trinchieri
Journal of Clinical Immunology 1994
Interleukin 12: A key modulator of immune function
SF Wolf, D Sieburth, J Sypek
Stem Cells 1994
Cytokines in the generation of immune responses to, and resolution of, virus infection
CA Biron
Current Opinion in Immunology 1994
Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells
J Punnonen, G Aversa, BG Cocks, JE Vries
Allergy 1994
Does Atopic Dermatitis Result from Cytokine Dysregulation?
P Dupuy
Journal of Investigative Dermatology 1994
A reasonable Approach for the Treatment of HIV Infection in the Early Phase with Ozonetherapy (Autohaemotherapy). How 'Inflammatory' Cytokines may have A therapeutic Role
V Bocci
Mediators of Inflammation 1994
Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites
FD Finkelman, KB Madden, AW Cheever, IM Katona, SC Morris, MK Gately, BR Hubbard, WC Gause, JF Urban
Journal of Experimental Medicine 1994
Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis
KV Clemons, E Brummer, DA Stevens
Antimicrobial agents and chemotherapy 1994
Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection
SL Reiner, S Zheng, ZE Wang, L Stowring, RM Locksley
Journal of Experimental Medicine 1994
La participation des cytokines au cours des mécanismes allergiques
JM Cavaillon
Immuno-analyse & Biologie Spécialisée 1994
Humoral immunity in aging
R Paganelli, E Scala, I Quinti, IJ Ansotegui
Aging clinical and experimental research 1994
Interleukin 12 and the regulation of CD4+ T-cell subset responses during murine Leishmaniasis
FP Heinzel
Parasitology Today 1994
Mechanisms of the Human Allergic Response: Clinical Implications
DY Leung
Pediatric Clinics of North America 1994
Observations on the Response of the Nasal Mucosa to Allergens
RM Naclerio, FM Baroody
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 1994
The importance of Th2-like cells in the pathogenesis of airway allergic inflammation
M Ricci, O Rossi, M Bertoni, A Matucci
Clinical & Experimental Allergy 1993
The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer
F Mattner, S Fischer, S Guckes, S Jin, H Kaulen, E Schmitt, E Rüde, T Germann
European Journal of Immunology 1993
Interleukin-12: A Recently Discovered Cytokine with Potential for Enhancing Cell-Mediated Immune Responses to Tumors
MK Gately
Cancer Investigation 1993
Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells
J Punnonen, G Aversa, BG Cocks, AN McKenzie, S Menon, G Zurawski, RW Malefyt, JE de Vries
Proceedings of the National Academy of Sciences 1993
The cytokine wall chart
F Burke, MS Naylor, B Davies, F Balkwill
Immunology Today 1993
Cytokines. 3. Cytokines in asthma
DS Robinson, SR Durham, AB Kay
Thorax 1993
The biological and clinical significance of helper T-cell subsets in the human
KM Müller, C Hauser
Experimental Dermatology 1992
Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation
G Trinchieri, M Wysocka, A D'Andrea, M Rengaraju, M Aste-Amezaga, M Kubin, NM Valiante, J Chehimi
Progress in Growth Factor Research 1992
Teil I: Referate
J Berendes, E Lehnhardt
1983

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