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Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria.

W Lewis, … , A Chomyn, T Papoian

W Lewis, … , A Chomyn, T Papoian

Published April 1, 1992
Citation Information: J Clin Invest. 1992;89(4):1354-1360. https://doi.org/10.1172/JCI115722.

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Title and authors	Publication	Year
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Muscle Toxicity of Drugs: When Medication Turns Physiology into Pathophysiology L Janssen, N Allard, C Saris, J Keijer, MT Hopman, S Timmers	Physiological reviews	2019
Mitochondrial dysfunctions in HIV infection and antiviral drug treatment KK Ganta, B Chaubey	Expert Opinion on Drug Metabolism & Toxicology	2019
Endothelial mitochondrial senescence accelerates cardiovascular disease in antiretroviral-receiving HIV patients YF Chen, TR Dugas	Toxicology Letters	2019
Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine A Santos-Llamas, MJ Monte, JJ Marin, MJ Perez	Archives of Toxicology	2018
Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants Y Will, JA Dykens		2018
Zidovudine-Mediated Autophagy Inhibition Enhances Mitochondrial Toxicity in Muscle Cells H Lin, MV Stankov, J Hegermann, R Budida, D Panayotova-Dimitrova, RE Schmidt, GM Behrens	Antimicrobial agents and chemotherapy	2018
A combined in vitro approach to improve the prediction of mitochondrial toxicants J Eakins, C Bauch, H Woodhouse, B Park, S Bevan, C Dilworth, P Walker	Toxicology in Vitro	2016
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Absence of a Universal Mechanism of Mitochondrial Toxicity by Nucleoside Analogs KC Lund, LR Peterson, KB Wallace	Antimicrobial agents and chemotherapy	2007
Zidovudine Inhibits Thymidine Phosphorylation in the Isolated Perfused Rat Heart D Susan-Resiga, AT Bentley, MD Lynx, DD LaClair, EE McKee	Antimicrobial agents and chemotherapy	2007
3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria MD Lynx, EE McKee	Biochemical Pharmacology	2006
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Deficit in cytochrome c oxidase activity induced in rat sperm mitochondria by in vivo exposure to zidovudine LR Dominique, D Emmanuel, B Eric, J Pierre, DA Marta	International Journal of Andrology	2003
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Toxicity of Nucleoside Analogues Used to Treat AIDS and the Selectivity of the Mitochondrial DNA Polymerase H Lee, J Hanes, KA Johnson	Biochemistry	2003
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Mitochondrial dysfunction and antiretroviral nucleoside analog toxicities: what is the evidence? T Dagan, C Sable, J Bray, M Gerschenson	Mitochondrion	2002
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Mitochondrial DNA Depletion, Oxidative Stress, and Mutation: Mechanisms 0f Dysfunction from Nucleoside Reverse Transcriptase Inhibitors W Lewis, WC Copeland, BJ Day	Laboratory Investigation	2001
Mitochondrial Alterations with Mitochondrial DNA Depletion in the Nerves of AIDS Patients with Peripheral Neuropathy Induced by 2′3′-Dideoxycytidine (ddC) MC Dalakas, C Semino-Mora, M Leon-Monzon	Laboratory Investigation	2001
Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction T Ide, H Tsutsui, S Hayashidani, D Kang, N Suematsu, K Nakamura, H Utsumi, N Hamasaki, A Takeshita	Circulation research	2001
Early effects of AZT on mitochondrial functions in the absence of mitochondrial DNA depletion in rat myotubes O Cazzalini, MC Lazzè, L Iamele, LA Stivala, L Bianchi, P Vaghi, A Cornaglia, A Calligaro, D Curti, A Alessandrini, E Prosperi, V Vannini	Biochemical Pharmacology	2001
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Peripheral neuropathy and antiretroviral drugs MC Dalakas	Journal of the peripheral nervous system : JPNS	2001
Antiviral l -Nucleosides Specific for Hepatitis B Virus Infection ML Bryant, EG Bridges, L Placidi, A Faraj, AG Loi, C Pierra, D Dukhan, G Gosselin, JL Imbach, B Hernandez, A Juodawlkis, B Tennant, B Korba, P Cote, P Marion, E Cretton-Scott, RF Schinazi, JP Sommadossi	Antimicrobial agents and chemotherapy	2001
Defects of Intergenomic Communication: Where Do We Stand? M Hirano, TH Vu	Brain Pathology	2000
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Fetal Patas Monkeys Sustain Mitochondrial Toxicity As a Result of in Utero Zidovudine Exposure M Gerschenson, MC Poirier	Annals of the New York Academy of Sciences	2000
Functional aerobic impairment in adolescents seropositive for HIV: A quasiexperimental analysis RE Keyser, L Peralta, WT Cade, S Miller, J Anixt	Archives of Physical Medicine and Rehabilitation	2000
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Cardiomyopathy in AIDS: A pathophysiological perspective W Lewis	Progress in Cardiovascular Diseases	2000
Effect of 1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-5-ethyluracil on mitochondrial functions in HepG2 cells L Cui, A Faraj, JP Sommadossi	Antiviral Research	1999
Zidovudine-induced experimental myopathy: dual mechanism of mitochondrial damage A Masini, C Scotti, A Calligaro, O Cazzalini, LA Stivala, L Bianchi, F Giovannini, D Ceccarelli, U Muscatello, A Tomasi, V Vannini	Journal of the Neurological Sciences	1999
Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver: Zidovudine (AZT) Causes an Oxidation of Mitochondrial DNA in Mouse Liver JG de la Asunción, ML Olmo, J Sastre, FV Pallardó, J Viña	Hepatology	1999
AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins JG de la Asunción, ML Olmo, J Sastre, A Millán, A Pellín, FV Pallardó, J Viña	Journal of Clinical Investigation	1998
Mitochondrial sensitivity to AZT LF Pereira, MB Oliveira, EG Carnieri	Cell Biochemistry and Function	1998
Clinical, histological and molecular reversibility of zidovudine myopathy F Masanés, A Barrientos, M Cebrián, E Pedrol, O Miró, J Casademont, JM Grau	Journal of the Neurological Sciences	1998
Increased plasma Gln and Leu Ra and inappropriately low muscle protein synthesis rate in AIDS wasting KE Yarasheski, JJ Zachwieja, J Gischler, J Crowley, MM Horgan, WG Powderly	The American journal of physiology	1998
Oxidative Stress in Skeletal Muscle AZ Reznick, L Packer, CK Sen, JO Holloszy, MJ Jackson		1998
Characterization of the Native and Recombinant Catalytic Subunit of Human DNA Polymerase γ: Identification of Residues Critical for Exonuclease Activity and Dideoxynucleotide Sensitivity MJ Longley, PA Ropp, SE Lim, WC Copeland	Biochemistry	1998
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Stavudine:pharmacology,clinical use and future role GJ Moyle	Expert Opinion on Investigational Drugs	1997
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Insensitivity of cultured rat cortical neurons to mitochondrial DNA synthesis inhibitors GJ Wang, LM Nutter, SA Thayer	Biochemical Pharmacology	1997
Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells E Benbrik, P Chariot, S Bonavaud, M Ammi-Saı̈d, E Frisdal, C Rey, R Gherardi, G Barlovatz-Meimon	Journal of the Neurological Sciences	1997
Carnitine Today CD Simone, G Famularo		1997
Death of Bystander Cells by a Novel Pathway Involving Early Mitochondrial Damage in Human Immunodeficiency Virus–Related Lymphadenopathy M Carbonari, AM Pesce, M Cibati, A Modica, L Dell'Anna, G D'Offizi, A Angelici, S Uccini, A Modesti, M Fiorilli	Blood	1997
Mechanisms for the anti-hepatitis B virus activity and mitochondrial toxicity of fialuridine (FIAU) JM Colacino	Antiviral Research	1996
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AZT Incorporation into Mitochondria: Study in a Human Myeloid Cell Line NJ Nusbaum, PE Joseph	DNA and Cell Biology	1996
Hepatic Morphological Alterations Induced by Zidovudine (ZDV) in an Experimental Model T Corcuera, MJ Alonso, A Picazo, F Gómez, M Roldán, M Abad, E Muñoz, A López-Bravo	Pathology - Research and Practice	1996
Incorporation of fialuridine (FIAU) into mitochondrial DNA and effects of FIAU on the morphology of mitochondria in human hepatoblastoma cells JM Colacino, JW Horn, DM Horn, FC Richardson	Toxicology in Vitro	1996
Effect of β-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells L Cui, RF Schinazi, G Gosselin, JL Imbach, CK Chu, RF Rando, GR Revankar, JP Sommadossi	Biochemical Pharmacology	1996
Drug Evaluations: Drug Evaluation Anti-infectives: Activity and role of lamivudine in the treatment of adults with human immunodeficiency virus type 1 infection: A review G Moyle	Expert Opinion on Investigational Drugs	1996
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Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy TM Sinnwell, K Sivakumar, S Soueidan, C Jay, JA Frank, AC McLaughlin, MC Dalakas	Journal of Clinical Investigation	1995
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity B Fromenty, D Pessayre	Pharmacology & Therapeutics	1995
Mitochondrial toxicity of antiviral drugs W Lewis, MC Dalakas	Nature Medicine	1995
Early features of zidovudine-associated myopathy: histopathological findings and clinical correlations EJ Cupler, C Jay, MC Dalakas, MJ Danon, M Ropka, K Hench	Acta Neuropathologica	1995
Hepatic Failure and Lactic Acidosis Due to Fialuridine (FIAU), an Investigational Nucleoside Analogue for Chronic Hepatitis B R McKenzie, MW Fried, R Sallie, H Conjeevaram, AM di Bisceglie, Y Park, B Savarese, D Kleiner, M Tsokos, C Luciano, T Pruett, JL Stotka, SE Straus, JH Hoofnagle	New England Journal of Medicine	1995
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The intracellular phosphorylation of (−)-2′-deoxy-3′-thiacytidine (3TC) and the incorporation of 3TC 5′-monophosphate into DNA by HIV-1 reverse transcriptase and human DNA polymerase γ NM Gray, CL Marr, CR Penn, JM Cameron, RC Bethell	Biochemical Pharmacology	1995
Synthesis of a Photoaffinity Analog of 3′-Azidothymidine, 5-Azido-3′-azido-2′,3′-dideoxyuridine.: INTERACTIONS WITH HERPESVIRUS THYMIDINE KINASE AND CELLULAR ENZYMES F Mao, TM Rechtin, R Jones, AA Cantu, LS Anderson, A Radominska, MP Moyer, RR Drake	The Journal of biological chemistry	1995
Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration FC Richardson, JA Engelhardt, RR Bowsher	Proceedings of the National Academy of Sciences	1994
Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture JM Colacino, SK Malcolm, SR Jaskunas	Antimicrobial agents and chemotherapy	1994
Expression of cytochrome c oxidase subunits encoded by mitochondrial or nuclear DNA in the muscle of patients with zidovudine myopathy P Chariot, G Bonne, FJ Authier, C Marsac, R Gherardi	Journal of the Neurological Sciences	1994
In vitro studies of the toxicity of nucleoside analogues used in the treatment of HIV infection OP Flint	Toxicology in Vitro	1994
Mitochondrial Disorders in Neurology LP Rowland	Mitochondrial Disorders in Neurology	1994
Measuring the Effects of Nucleoside Analogs on Mitochondrial DNA Content Using the Polymerase Chain Reaction MA Abbott, MD Kowolenko, GL Warner	Toxicology Methods	1994
Mammalian DNA Polymerases .alpha., .beta., .gamma., .delta., and .epsilon. Incorporate Fialuridine (FIAU) Monophosphate into DNA and Are Inhibited Competitively by FIAU Triphosphate W Lewis, RR Meyer, JF Simpson, JM Colacino, FW Perrino	Biochemistry	1994
Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine W Lewis, JF Simpson, RR Meyer	Circulation research	1994
Recent advances in the neurology of HIV infection RK Petty	Postgraduate medical journal	1994
Cytochromec oxidase reaction improves histopathological assessment of zidovudine myopathy P Chariot, I Monnet, R Gherardi	Annals of Neurology	1993
Alterations in mitochondrial function and morphology in chronic liver disease: Pathogenesis and potential for therapeutic intervention S Krähenbühl	Pharmacology & Therapeutics	1993
Anthracyclines selectively decrease alpha cardiac actin mRNA abundance in the rat heart T Papoian, W Lewis	The American Journal of Pathology	1992
Dilated cardiomyopathy in a zidovudine-treated AIDS patient G d'Amati, W Kwan, W Lewis	Cardiovascular Pathology	1992

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