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Citations to this article

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.
B Tesfamariam, … , M L Brown, R A Cohen
B Tesfamariam, … , M L Brown, R A Cohen
Published May 1, 1991
Citation Information: J Clin Invest. 1991;87(5):1643-1648. https://doi.org/10.1172/JCI115179.
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Research Article Article has an altmetric score of 6

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

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Abstract

A possible relationship between protein kinase C activation and impaired receptor-mediated endothelium-dependent relaxation in diabetes mellitus was examined in isolated aorta from normal rabbit exposed to elevated glucose. Aorta treated for 10 min with 4-phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, showed decreased relaxations to the endothelium-dependent vasodilator, acetylcholine, similar to normal aorta exposed to elevated glucose (22 and 44 mM) for 6 h. Relaxations to the receptor-independent endothelium-dependent vasodilator, A23187, and those caused by the direct smooth muscle vasodilator, sodium nitroprusside, were unaffected by treatment with PMA or exposure to elevated glucose. Indomethacin increased relaxations to acetylcholine of aorta treated with PMA indicating a role for vasoconstrictor prostanoids. PMA caused a significant increase in basal and acetylcholine-stimulated release of vasoconstrictor prostanoids including thromboxane A2 from aortic segments with, but not without endothelium. Protein kinase C inhibitors, H-7 or sphingosine, restored the abnormal acetylcholine-induced relaxations as well as suppressed the abnormal release of prostanoids in aorta exposed to elevated glucose. These findings suggest that the dysfunction of receptor-mediated endothelium-dependent relaxation associated with exposure to elevated glucose is due to increased production of vasoconstrictor prostanoids by the endothelium as a consequence of protein kinase C activation.

Authors

B Tesfamariam, M L Brown, R A Cohen

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Citations to this article in year 2007 (11)

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I Posadas, V Vellecco, P Santos, J Prieto-Lloret, V Ceña
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Diabetes-associated macrovasculopathy: pathophysiology and pathogenesis
S Rahman, T Rahman, AA Ismail, AR Rashid
Diabetes, Obesity and Metabolism 2007
Effect of ethanol consumption on blood pressure and rat mesenteric arterial bed, aorta and carotid responsiveness
CR Tirapelli, AF Leone, EB Coelho, LB Resstel, FM Corrêa, VL Lanchote, SA Uyemura, CM Padovan, AM Oliveira
Journal of Pharmacy and Pharmacology 2007
The Deleterious Effects of Hyperglycemia on Platelet Function in Diabetic Patients With Acute Coronary Syndromes
MI Worthley, AS Holmes, SR Willoughby, AM Kucia, T Heresztyn, S Stewart, YY Chirkov, CJ Zeitz, JD Horowitz
Journal of the American College of Cardiology 2007
Effect of chronic ethanol consumption on endothelin-1 generation and conversion of exogenous big-endothelin-1 by the rat carotid artery
CR Tirapelli, DA Casolari, A Yogi, RC Tostes, E Legros, VL Lanchote, SA Uyemura, AM de Oliveira
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HA Hadi, JA Suwaidi
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Carvedilol ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats
GS Fu, H Huang, F Chen, HP Wang, LB Qian, XY Ke, Q Xia
European Journal of Pharmacology 2007
Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker ( fa / fa ) rats
EC Eringa, CD Stehouwer, MH Roos, N Westerhof, P Sipkema
American journal of physiology. Endocrinology and metabolism 2007
Effects of an oral glucose tolerance test on the myogenic response in healthy individuals
ME Lott, C Hogeman, M Herr, R Gabbay, LI Sinoway
American journal of physiology. Heart and circulatory physiology 2007
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2007

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Referenced in 12 patents
Referenced in 1 clinical guideline sources
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