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Citations to this article

Vasoactive intestinal peptide in human nasal mucosa.
J N Baraniuk, … , J H Shelhamer, M A Kaliner
J N Baraniuk, … , J H Shelhamer, M A Kaliner
Published September 1, 1990
Citation Information: J Clin Invest. 1990;86(3):825-831. https://doi.org/10.1172/JCI114780.
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Research Article Article has an altmetric score of 3

Vasoactive intestinal peptide in human nasal mucosa.

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Abstract

Vasoactive intestinal peptide (VIP), which is present with acetylcholine in parasympathetic nerve fibers, may have important regulatory functions in mucous membranes. The potential roles for VIP in human nasal mucosa were studied using an integrated approach. The VIP content of human nasal mucosa was determined to be 2.84 +/- 0.47 pmol/g wet weight (n = 8) by RIA. VIP-immunoreactive nerve fibers were found to be most concentrated in submucosal glands adjacent to serous and mucous cells. 125I-VIP binding sites were located on submucosal glands, epithelial cells, and arterioles. In short-term explant culture, VIP stimulated lactoferrin release from serous cells but did not stimulate [3H]glucosamine-labeled respiratory glycoconjugate secretion. Methacholine was more potent than VIP, and methacholine stimulated both lactoferrin and respiratory glycoconjugate release. The addition of VIP plus methacholine to explants resulted in additive increases in lactoferrin release. Based upon the autoradiographic distribution of 125I-VIP binding sites and the effects on explants, VIP derived from parasympathetic nerve fibers may function in the regulation of serous cell secretion in human nasal mucosa. VIP may also participate in the regulation of vasomotor tone.

Authors

J N Baraniuk, J D Lundgren, M Okayama, J Mullol, M Merida, J H Shelhamer, M A Kaliner

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Year: 2024 2023 2021 2020 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 Total
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Citations to this article in year 2011 (2)

Title and authors Publication Year
Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: a review
D Wu, D Lee, YK Sung
Respiratory Research 2011
Alterations of Vasoactive Intestinal Polypeptide Receptors in Allergic Rhinitis
DH Kim, IH Park, JS Cho, YM Lee, H Choi, HM Lee
American journal of rhinology & allergy 2011

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Referenced in 1 clinical guideline sources
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