Vasoactive intestinal peptide (VIP), which is present with acetylcholine in parasympathetic nerve fibers, may have important regulatory functions in mucous membranes. The potential roles for VIP in human nasal mucosa were studied using an integrated approach. The VIP content of human nasal mucosa was determined to be 2.84 +/- 0.47 pmol/g wet weight (n = 8) by RIA. VIP-immunoreactive nerve fibers were found to be most concentrated in submucosal glands adjacent to serous and mucous cells. 125I-VIP binding sites were located on submucosal glands, epithelial cells, and arterioles. In short-term explant culture, VIP stimulated lactoferrin release from serous cells but did not stimulate [3H]glucosamine-labeled respiratory glycoconjugate secretion. Methacholine was more potent than VIP, and methacholine stimulated both lactoferrin and respiratory glycoconjugate release. The addition of VIP plus methacholine to explants resulted in additive increases in lactoferrin release. Based upon the autoradiographic distribution of 125I-VIP binding sites and the effects on explants, VIP derived from parasympathetic nerve fibers may function in the regulation of serous cell secretion in human nasal mucosa. VIP may also participate in the regulation of vasomotor tone.
J N Baraniuk, J D Lundgren, M Okayama, J Mullol, M Merida, J H Shelhamer, M A Kaliner
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The Nose and Sinuses in Respiratory Disorders | 2017 |
Neuropeptides in Respiratory Medicine
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2017 | |
Nonallergic Rhinitis
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Immunology and Allergy Clinics of North America | 2016 |
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Current Treatment Options in Allergy | 2016 |
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Physiological reviews | 2015 |
Diseases of the Sinuses
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2014 | |
Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion
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The FASEB Journal | 2013 |
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The Journal of biological chemistry | 2012 |
Sleep Disordered Breathing in Children
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2012 | |
Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: a review
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American journal of rhinology & allergy | 2011 |
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Journal of Clinical Investigation | 2010 |
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Cummings Otolaryngology - Head and Neck Surgery
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Cummings Otolaryngology - Head and Neck Surgery | 2010 |
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Journal of virology | 2009 |
Actin reorganization is involved in vasoactive intestinal peptide induced human mast cells priming to fraktalkine-induced chemotaxis
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International journal of general medicine | 2009 |
Breaking Human Cytomegalovirus Major Immediate-Early Gene Silence by Vasoactive Intestinal Peptide Stimulation of the Protein Kinase A-CREB-TORC2 Signaling Cascade in Human Pluripotent Embryonal NTera2 Cells
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Journal of virology | 2009 |
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Clinical & Experimental Allergy | 2008 |
Neuroinvasion of the 263K scrapie strain after intranasal administration occurs through olfactory-unrelated pathways
M Sbriccoli, F Cardone, A Valanzano, M Lu, S Graziano, A Pascalis, L Ingrosso, G Zanusso, S Monaco, M Bentivoglio, M Pocchiari |
Acta Neuropathologica | 2008 |
Expression of substance P, vasoactive intestinal peptide and heat shock protein 70 in nasal mucosal smears of patients with allergic rhinitis: investigation using a liquid-based method
T Chalastras, P Nicolopoulou-Stamati, E Patsouris, A Eleftheriadou, D Kandiloros, I Yiotakis, M Gonidi, P Athanassiadou |
The Journal of Laryngology & Otology | 2008 |
Increased Nerve Fiber Expression of Sensory Sodium Channels Nav1.7, Nav1.8, and Nav1.9 in Rhinitis
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The Laryngoscope | 2008 |
Nasal challenge with allergen leads to maxillary sinus inflammation
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Journal of Allergy and Clinical Immunology | 2008 |
2D PAGE: Sample Preparation and Fractionation
A Posch |
2008 | |
Parasympathetic control of airway submucosal glands: central reflexes and the airway intrinsic nervous system
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Autonomic neuroscience : basic & clinical | 2007 |
Submucous turbinectomy combined with posterior nasal neurectomy in the management of severe allergic rhinitis: Clinical outcomes and local cytokine changes
T Ogawa, S Takeno, T Ishino, K Hirakawa |
Auris, Nasus, Larynx | 2007 |
Novel concepts of neuropeptide-based drug therapy: Vasoactive intestinal polypeptide and its receptors
DA Groneberg, KF Rabe, A Fischer |
European Journal of Pharmacology | 2006 |
Identification of human nasal mucous proteins using proteomics
B Casado, LK Pannell, P Iadarola, JN Baraniuk |
PROTEOMICS | 2005 |
Human neuroglobin protein in cerebrospinal fluid
B Casado, LK Pannell, G Whalen, DJ Clauw, JN Baraniuk |
Proteome Science | 2005 |
Secretoneurin is released into human airways by topical histamine but not capsaicin
M Korsgren, R Fischer-Colbrie, M Andersson, WB Coman, A Mackay-Sim, CG Persson, F Sundler, B Wallwork, L Greiff |
Allergy | 2005 |
A chronic fatigue syndrome – related proteome in human cerebrospinal fluid
JN Baraniuk, B Casado, H Maibach, DJ Clauw, LK Pannell, SH S |
BMC neurology | 2005 |
Neurogenic mechanisms in bronchial inflammatory diseases
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Allergy | 2004 |
Chlorine inhalation produces nasal airflow limitation in allergic rhinitic subjects without evidence of neuropeptide release
D Shusterman, J Balmes, MA Murphy, CF Tai, J Baraniuk |
Neuropeptides | 2004 |
Neural Expression and Increased Lavage Fluid Levels of Secretoneurin in Seasonal Allergic Rhinitis
M Korsgren, JS Erjefält, J Hinterhölzl, R Fischer-Colbrie, CA Emanuelsson, M Andersson, CG Persson, A Mackay-Sim, F Sundler, L Greiff |
American journal of respiratory and critical care medicine | 2003 |
Elevation of the Nasal Mucosal Surface Temperature After Warming of the Feet Occurs Via a Neural Reflex
P Assanasen, FM Baroody, L Haney, M deTineo, E Naureckas, J Solway, RM Naclerio |
Acta Oto-laryngologica | 2003 |
Neurology of allergic inflammation and rhinitis
BJ Canning |
Current Allergy and Asthma Reports | 2002 |
The New Angiotherapy
TP Fan, EC Kohn |
2002 | |
Vasoactive Intestinal Polypeptide as Mediator of Asthma
DA Groneberg, J Springer, A Fischer |
Pulmonary Pharmacology & Therapeutics | 2001 |
Allergic Rhinitis and Its Impact on Asthma
J Bousquet, P Cauwenberge, N Khaltaev |
Journal of Allergy and Clinical Immunology | 2001 |
Cold-Induced Rhinitis in Skiers—Clinical Aspects and Treatment with Ipratropium Bromide Nasal Spray: A Randomized Controlled Trial
P Bonadonna, G Senna, P Zanon, G Cocco, R Dorizzi, F Gani, M Landi, M Restuccia, A Feliciello, G Passalacqua |
American journal of rhinology | 2001 |
Expression of vasoactive intestinal peptide, calcitonin gene-related peptide, substance P, and intermediate neurofilaments in nasal mucosal nerve fibers of horses without nasal disease
BM Corcoran, IG Mayhew, CN Hahn, DR Prince |
American Journal of Veterinary Research | 2000 |
Endothelin in nasal mucosa: role in nasal function and inflammation
Mullol, Picado |
Clinical & Experimental Allergy | 2000 |
Non-specific activation of human eosinophil functional responses by vasoactive intestinal peptide
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Allergology International | 2000 |
Neuroregulation by vasoactive intestinal peptide (VIP) of mucus secretion in ferret trachea: activation of BKCachannels and inhibition of neurotransmitter release
YC Liu, HJ Patel, AM Khawaja, MG Belvisi, DF Rogers |
British Journal of Pharmacology | 1999 |
Submucous turbinectomy decreases not only nasal stiffness but also sneezing and rhinorrhea in patients with perennial allergic rhinitis
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Clinical & Experimental Allergy | 1999 |
Comparison of the response to histamine challenge of the nose and the maxillary sinus: effect of loratadine
FM Baroody, A Gungor, M deTineo, L Haney, C Blair, RM Naclerio |
Journal of applied physiology | 1999 |
Histochemical and Immunocytochemical Study of Nitrergic Innervation in Human Nasal Mucosa
A Riederer, B Mayer, B Held, J Wörl |
The Annals of otology, rhinology, and laryngology | 1999 |
Neutral endopeptidase 24.11: its physiologic and possibly pathophysiologic role in inflammation with special effect on respiratory inflammation
P Koehne, C Schäper, K Graf, G Kunkel |
Allergy | 1998 |
Nitric Oxide Synthase in the Innervation of the Human Nasal Mucosa: Correlation With Neuropeptides and Tyrosine Hydroxylase
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The Laryngoscope | 1998 |
Distribution and Quantity of Neuroendocrine Markers in Allergic Rhinitis
SY M |
Acta Oto-laryngologica | 1998 |
Neuropeptides
JN Baraniuk |
American journal of rhinology | 1998 |
Muscarinic Ciliostimulation Requires Endogenous Prostaglandin Production
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American journal of rhinology | 1998 |
Neurogenic inflammation: with additional discussion of central and perceptual integration of nonneurogenic inflammation
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Environmental Health Perspectives | 1997 |
Vasoactive intestinal peptide (VIP) induces IL-6 and IL-8, but not G-CSF and GM-CSF release from a human bronchial epithelial cell line
J Mullol, JN Baraniuk, M Pitale, T Benfield, C Logun, C Picado, JH Shelhamer |
Neuropeptides | 1997 |
The Kinin System
A Schmaier |
The Kinin System | 1997 |
Effects of Anti-Allergic Drugs on Substance P (SP) and Vasoactive Intestinal Peptide (VIP) in Nasal Secretions
M Shinoda, N Watanabe, T Suko, G Mogi, M Takeyama |
American journal of rhinology | 1997 |
Vasoactive intestinal peptide induces S(alpha)/S(mu) switch circular DNA in human B cells
S Fujieda, JA Waschek, K Zhang, A Saxon |
Journal of Clinical Investigation | 1996 |
Nasal inflammation in patients with obstructive sleep apnea
I Rubinstein |
The Laryngoscope | 1995 |
Calcitonin gene-related peptide in vitro stimulation of ciliary beat in human upper respiratory cilia
PJ Schuil, JG Rosmalen, K Graamans, EH Huizing |
European Archives of Oto-Rhino-Laryngology | 1995 |
Parasympathique, atropiniques de synthèse et muqueuse nasale
A Coste, M Rugina, V Ducroz, P Bedbeder, R Peynegre |
Revue Française d'Allergologie et d'Immunologie Clinique | 1995 |
Substance P and Ciliary Beat of Human Upper Respiratory Cilia in Vitro
PJ Schuil, MT Berge, K Graamans, JM van Gelder, EH Huizing |
The Annals of otology, rhinology, and laryngology | 1995 |
Viral and Other Infections of the Human Respiratory Tract
S Myint, D Taylor-Robinson |
1995 | |
Functional effects of phosphoramidon and captopril on exogenous neuropeptides in human nasal mucosa
C Chtelain, N Pochon, JS Lacroix |
European Archives of Oto-Rhino-Laryngology | 1995 |
Cellular mechanisms in activation of Na-K-Cl cotransport in nasal gland acinar cells of guinea pigs
K Ikeda, D Wu, T Takasaka |
The Journal of Membrane Biology | 1995 |
Effect of Terfenadine on Substance P and Vasoactive Intestinal Polypeptide Concentrations in Nasal Secretions from Patients with Nasal Allergy
M Takeyama, K Mori, N Morikawa, S Asakura, T Chaen, N Watanabe, G Mogi |
Journal of Pharmacy and Pharmacology | 1994 |
Neuropeptides in nasal mucosa
CJ Woodhead |
Clinical Otolaryngology | 1994 |
Nitric oxide synthase-immunoreactive nerve fibers in the nasal mucosa of the rat
T Hanazawa, A Konno, T Kaneko, K Tanaka, H Ohshima, H Esumi, T Chiba |
Brain Research | 1994 |
H1-Receptor Antagonists in the Management of Allergic Rhinitis: A Comparative Review
K Kontou-Fili |
Clinical immunotherapeutics | 1994 |
Endothelin-induced Vasoconstriction in Rabbit Nasal Mucosa
M Benazzo, A Casasco, P Lovotti, AI Cornaglia, M Casasco, JM Polak |
Acta Oto-laryngologica | 1994 |
Observations on the Response of the Nasal Mucosa to Allergens
RM Naclerio, FM Baroody |
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery | 1994 |
Distribution of NADPH-diaphorase positive nerve fibers in the rat nasal mucosa
T Hanazawa, H Motosugi, A Konno, T Kaneko, K Tanaka, T Chiba |
Neuroscience Letters | 1993 |
Reflex Activation of Nasal Secretion by Unilateral Inhalation of Cold Dry Air
G Philip, R Jankowski, FM Baroody, RM Naclerio, AG Togias |
American journal of respiratory and critical care medicine | 1993 |
Endothelin in Human Nasal Mucosa
J Mullol, BA Chowdhury, MV White, K Ohkubo, RD Rieves, J Baraniuk, JN Hausfeld, JH Shelhamer, MA Kaliner |
American journal of respiratory cell and molecular biology | 1993 |
Human Nasal Mucosal Neutral Endopeptidase (NEP): Location, Quantitation, and Secretion
K Ohkubo, JN Baraniuk, RJ Hohman, HC Kaulbach, JN Hausfeld, M Merida, MA Kaliner |
American journal of respiratory cell and molecular biology | 1993 |
Muscarinic Receptor Subtypes in Human Nasal Mucosa: Characterization, Autoradiographic Localization, and Function In Vitro
M Okayama, J Mullol, JN Baraniuk, JN Hausfeld, B Feldman, M Merida, JH Shelhamer, MA Kaliner |
American journal of respiratory cell and molecular biology | 1993 |
Neuropéptidos. Su papel en la fisiopatología respiratoria humana
J Mullol, C Picado |
Archivos de Bronconeumología | 1993 |
Substance P and Vasoactive Intestinal Peptide in Nasal Secretions and Plasma from Patients with Nasal Allergy
T Chaen, N Watanabe, K Mori, G Mogi, M Takeyama |
The Annals of otology, rhinology, and laryngology | 1993 |
Occurrence, distribution and possible role of the regulatory peptide endothelin in the nasal mucosa
A Casasco, M Benazzo, M Casasco, AI Cornaglia, DR Springall, A Calligaro, E Mira, JM Polak |
Cell and Tissue Research | 1993 |
Sensory, parasympathetic, and sympathetic neural influences in the nasal mucosa
JN Baraniuk |
Journal of Allergy and Clinical Immunology | 1992 |
The effects of neuropeptides on mucous glycoprotein secretion from human nasal mucosa in vitro
J Mullol, RD Rieves, JN Baraniuk, JD Lundgren, M Merida, JH Hausfeld, JH Shelhamer, MA Kaliner |
Neuropeptides | 1992 |
Mucus secretion and inflammation
JD Lundgren, JN Baraniuk |
Pulmonary Pharmacology | 1992 |
Endothelin-1 Stimulates Eicosanoid Production in Cultured Human Nasal Mucosa
T Wu, J Mullol, RD Rieves, C Logun, J Hausfield, MA Kaliner, JH Shelhamer |
American journal of respiratory cell and molecular biology | 1992 |
Localization of m3 Muscarinic Receptor mRNA in Human Nasal Mucosa
JN Baraniuk, MA Kaliner, PJ Barnes |
American journal of rhinology | 1992 |
Neuropeptides in the Respiratory Tract: Part I
PJ Barnes, JN Baraniuk, MG Belvisi |
American journal of respiratory and critical care medicine | 1991 |
Human Nasal Respiratory Secretions and Host Defense
MA Kaliner |
American journal of respiratory and critical care medicine | 1991 |