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Citations to this article

Hypertonic saline increases vascular permeability in the rat trachea by producing neurogenic inflammation.
E Umeno, … , D M McDonald, J A Nadel
E Umeno, … , D M McDonald, J A Nadel
Published June 1, 1990
Citation Information: J Clin Invest. 1990;85(6):1905-1908. https://doi.org/10.1172/JCI114652.
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Research Article Article has an altmetric score of 6

Hypertonic saline increases vascular permeability in the rat trachea by producing neurogenic inflammation.

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Abstract

In this study, we examined whether inhalation of hypertonic saline aerosols increases vascular permeability in the rat trachea, and we examined the role of neurogenic inflammation in this response. Stereological point counting was performed to measure the percent area occupied by Monastral blue-labeled blood vessels as a means of quantifying the increase in vascular permeability in tracheal whole mounts. Hypertonic saline aerosols (3.6-14.4% NaCl) increased vascular permeability in a dose-dependent fashion compared with 0.9% NaCl. Thus, the area density of Monastral blue-labeled vessels after inhalation of 3.6% NaCl was greater (21.2 +/- 3.5% mean +/- SEM, n = 5) than after 0.9% NaCl aerosol (3.3 +/- 0.9%, n = 5, P less than 0.5). The neutral endopeptidase inhibitor phosphoramidon (2.5 mg/kg, i.v.) significantly potentiated the increase of vascular permeability caused by 3.6% NaCl. Desensitization of sensory nerve endings by pretreatment with capsaicin markedly reduced the usual increase in vascular permeability caused by 3.6% NaCl, but the increase in vascular permeability induced by aerosolized substance P (10(-4) M) was unchanged. These findings suggest that hypertonic saline increases vascular permeability in the rat trachea by stimulating the release of neuropeptides from sensory nerves.

Authors

E Umeno, D M McDonald, J A Nadel

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Total citations by year

Year: 2021 2019 2018 2017 2014 2013 2012 2011 2010 2009 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 Total
Citations: 1 1 1 1 1 2 1 1 2 9 3 1 3 5 2 4 4 6 3 4 3 6 4 7 9 4 88
Citation information
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Citations to this article in year 2009 (9)

Title and authors Publication Year
Sensory Nerves
BJ Canning, D Spina
2009
Sensory Nerves
BJ Canning, D Spina
2009
Sensory Nerves
BJ Canning, D Spina
2009
Sensory Nerves
BJ Canning, D Spina
2009
Sensory Nerves
BJ Canning, D Spina
2009
Sensory Nerves
BJ Canning, D Spina
2009
Sensory Nerves
BJ Canning, D Spina
2009
Frontiers in Neuroscience
K Panickar, S Bhathena
Fat Detection 2009
Endotoxin-induced translocation of interleukin-6 from lungs to the systemic circulation
E Tamagawa, K Suda, Y Wei, L Xing, T Mui, Y Li, SF van Eeden, SF Man, DD Sin
Innate immunity 2009

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Referenced in 2 clinical guideline sources
12 readers on Mendeley
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