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Citations to this article

Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages.
J C Mathison, … , K Glaser, R J Ulevitch
J C Mathison, … , K Glaser, R J Ulevitch
Published April 1, 1990
Citation Information: J Clin Invest. 1990;85(4):1108-1118. https://doi.org/10.1172/JCI114542.
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Research Article

Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages.

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Abstract

These experiments provide an explanation for the observation that two intravenous injections of lipopolysaccharide (LPS) spaced 5 h apart in rabbits cause tumor necrosis factor/cachectin (TNF) levels to rise in the blood only after the first LPS injection. Herein we show that treatment of elicited peritoneal exudate rabbit macrophages (PEM) with two doses of LPS given 9 h apart results in a marked reduction in TNF production by the second LPS exposure. This state of hyporesponsiveness is a result of adaptation to LPS, is induced by LPS concentrations that are 1,000-fold less than required to induce TNF production (picograms vs. nanograms), is characterized by a decrease in LPS-induced TNF mRNA without any change in TNF mRNA half-life, is not changed by including indomethacin in cultures, and is specific for LPS since LPS-adapted cells display a TNF response to heat-killed Staphylococcus aureus that is at least as good as that observed in control PEM.

Authors

J C Mathison, G D Virca, E Wolfson, P S Tobias, K Glaser, R J Ulevitch

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Pre-exposure of murine macrophages to lipopolysaccharide inhibits the induction of nitric oxide synthase and reduces leishmanicidal activity
A Severn, D Xu, J Doyle, LM Leal, CA O'Donnell, SJ Brett, DW Moss, FY Liew
European Journal of Immunology 1993
A critical role for monocytes and CD14 in endotoxin-induced endothelial cell activation
J Pugin, RJ Ulevitch, PS Tobias
Journal of Experimental Medicine 1993
CD14 and tolerance to lipopolysaccharide: biochemical and functional analysis
MO Labeta, JJ Durieux, G Spagnoli, N Fernandez, J Wijdenes, R Herrmann
Immunology 1993
Lipopolysaccharide-induced selective priming effects on tumor necrosis factor alpha and nitric oxide production in mouse peritoneal macrophages
X Zhang, DC Morrison
Journal of Experimental Medicine 1993
Differential regulation of cytokine production in lipopolysaccharide tolerance in mice
A Erroi, G Fantuzzi, M Mengozzi, M Sironi, SF Orencole, BD Clark, CA Dinarello, A Isetta, P Gnocchi, M Giovarelli
Infection and immunity 1993
Expression and Regulation of Tumor Necrosis Factor in Macrophages from Cystic Fibrosis Patients
KD Pfeffer, TP Huecksteadt, JR Hoidal
American journal of respiratory cell and molecular biology 1993
Recombinant Cytokines and Pulmonary Host Defense
JK Kolls, S Nelson, WR Summer
The American Journal of the Medical Sciences 1993
Host Defense Dysfunction in Trauma, Shock and Sepsis
E Faist, JL Meakins, FW Schildberg
1993
Pathophysiology of Shock, Sepsis, and Organ Failure
G Schlag, H Redl
1993
Activated macrophages depress the contractility of rabbit carotids via an L-arginine/nitric oxide-dependent effector mechanism. Connection with amplified cytokine release
C Bernard, B Szekely, I Philip, E Wollman, D Payen, A Tedgui
Journal of Clinical Investigation 1992
Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs
TR Martin, JC Mathison, PS Tobias, DJ Letúrcq, AM Moriarty, RJ Maunder, RJ Ulevitch
Journal of Clinical Investigation 1992
Cytokines tumor necrosis factor and interleukin-6 in experimental biliary obstruction in mice
MH Bemelmans, DJ Gouma, JW Greve, WA Buurman
Hepatology 1992
Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein
JD Lee, K Kato, PS Tobias, TN Kirkland, RJ Ulevitch
Journal of Experimental Medicine 1992
In vitro desensitization to lipopolysaccharide suppresses tumour necrosis factor, interleukin-1 and interleukin-6 gene expression in a similar fashion
HW Ziegler-Heitbrock, M Blumenstein, E Käfferlein, D Kieper, I Petersmann, S Endres, WA Flegel, H Northoff, G Riethmüller, JG Haas
Immunology 1992
Protection against lethal pneumococcal septicemia in pigs is associated with decreased levels of interleukin-6 in blood
HW Ziegler-Heitbrock, B Passlick, E Käfferlein, PG Coulie, JR Izbicki
Infection and immunity 1992
Effects of gamma interferon on release of tumor necrosis factor alpha from lipopolysaccharide-tolerant human monocyte-derived macrophages
M Matic, SR Simon
Infection and immunity 1992
Sepsis induces an early increased spontaneous release of hepatocellular stimulatory factor (interleukin-6) by Kupffer cells in both endotoxin tolerant and intolerant mice
A Ayala, MM Perrin, P Wang, IH Chaudry
Journal of Surgical Research 1992
Pathophysiology of pulmonary defense mechanisms
CM Mason, WR Summer, S Nelson
Journal of Critical Care 1992
Participation of Lipopolysaccharide-binding Protein in Lipopolysaccharide-dependent Macrophage Activation
PS Tobias, J Mathison, D Mintz, JD Lee, V Kravchenko, K Kato, J Pugin, RJ Ulevitch
American journal of respiratory cell and molecular biology 1992
Function of lipopolysaccharide (LPS)-binding protein (LBP) and CD14, the receptor for LPS/LBP complexes: a short review
RR Schumann
Research in Immunology 1992
In Vitro Tumor Necrosis Factor- α Secretion by Monocytes from Patients with Cystic Fibrosis
JS Elborn, D Norman, FM Delamere, DJ Shale
American journal of respiratory cell and molecular biology 1992
Molecular cloning of porcine alveolar macrophage-derived neutrophil chemotactic factors I and II: identification of porcine IL-8 and another intercrine-.alpha. protein
RB Goodman, DC Foster, SL Mathewes, SG Osborn, JL Kuijper, JW Forstrom, TR Martin
Biochemistry 1992
Dysregulation of in vitro cytokine production by monocytes during sepsis
C Munoz, J Carlet, C Fitting, B Misset, JP Blériot, JM Cavaillon
Journal of Clinical Investigation 1991
Regulation of tumor necrosis factor (TNF) release by murine peritoneal macrophages: role of cell stimulation and specific phagocytic plasma membrane receptors
M Stein, S Gordon
European Journal of Immunology 1991
Effect of cytokines and lipopolysaccharide on CD14 antigen expression in human monocytes and macrophages
R Landmann, C Ludwig, R Obrist, JP Obrecht
Journal of Cellular Biochemistry 1991
Tumor necrosis factor release from lipopolysaccharide-stimulated human monocytes: Lipopolysaccharide tolerance in vitro
M Matic, SR Simon
Cytokine 1991
Time course of IL-6 and TNFα release during endotoxin-induced endotoxin tolerance in rats
S Flohé, PC Heinrich, J Schneider, A Wendel, L Flohé
Biochemical Pharmacology 1991
Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides
FS Hagen, FJ Grant, JL Kuijper, CA Slaughter, CR Moomaw, K Orth, PJ O'Hara, RS Munford
Biochemistry 1991
Polymorphonuclear neutrophil contribution to induced tolerance to bacterial lipopolysaccharide
J Barroso-Aranda, GW Schmid-Schönbein, BW Zweifach, JC Mathison
Circulation research 1991
Identification of two neutrophil chemotactic peptides produced by porcine alveolar macrophages
RB Goodman, JW Forstrom, SG Osborn, EY Chi, TR Martin
The Journal of biological chemistry 1991
Response : CD14 and Immune Response to Lipopolysaccharide
SD Wright
Science 1991
Structure and Function of Lipopolysaccharide Binding Protein
RR Schumann, SR Leong, GW Flaggs, PW Gray, SD Wright, JC Mathison, PS Tobias, RJ Ulevitch
Science 1990

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