These experiments provide an explanation for the observation that two intravenous injections of lipopolysaccharide (LPS) spaced 5 h apart in rabbits cause tumor necrosis factor/cachectin (TNF) levels to rise in the blood only after the first LPS injection. Herein we show that treatment of elicited peritoneal exudate rabbit macrophages (PEM) with two doses of LPS given 9 h apart results in a marked reduction in TNF production by the second LPS exposure. This state of hyporesponsiveness is a result of adaptation to LPS, is induced by LPS concentrations that are 1,000-fold less than required to induce TNF production (picograms vs. nanograms), is characterized by a decrease in LPS-induced TNF mRNA without any change in TNF mRNA half-life, is not changed by including indomethacin in cultures, and is specific for LPS since LPS-adapted cells display a TNF response to heat-killed Staphylococcus aureus that is at least as good as that observed in control PEM.
J C Mathison, G D Virca, E Wolfson, P S Tobias, K Glaser, R J Ulevitch
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Lipopolysaccharide detection by the innate immune system may be an uncommon defence strategy used in nature.
Gauthier AE, Rotjan RD, Kagan JC |
Open Biology | 2022 |
COVID-19, what could sepsis, severe acute pancreatitis, gender differences, and aging teach us?
CG Gallo, S Fiorino, G Posabella, D Antonacci, A Tropeano, E Pausini, C Pausini, T Guarniero, W Hong, E Giampieri, I Corazza, L Federico, D de Biase, M Zippi, M Zancanaro |
Cytokine | 2021 |
Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N -acyl homoserine lactones
J Rayo, R Gregor, NT Jacob, R Dandela, L Dubinsky, A Yashkin, A Aranovich, M Thangaraj, O Ernst, E Barash, S Malitsky, BI Florea, BP Krom, EA Wiemer, VA Kickhoefer, LH Rome, JC Mathison, GF Kaufmann, HS Overkleeft, BF Cravatt, T Zor, KD Janda, RJ Ulevitch, VV Kravchenko, MM Meijler |
Proceedings of the National Academy of Sciences | 2021 |
Diurnal heat stress reduces pig intestinal integrity and increases endotoxin translocation
NK Gabler, D Koltes, S Schaumberger, GR Murugesan, N Reisinger |
2018 | |
Inflammation - From Molecular and Cellular Mechanisms to the Clinic: From Molecular and Cellular Mechanisms to the Clinic
JM Cavaillon, M Singer |
Inflammation - From Molecular and Cellular Mechanisms to the Clinic: From Molecular and Cellular Mechanisms to the Clinic | 2017 |
Compartment diversity in innate immune reprogramming
O Rasid, JM Cavaillon |
Microbes and Infection | 2017 |
Exotoxins and endotoxins: Inducers of inflammatory cytokines
JM Cavaillon |
Toxicon : official journal of the International Society on Toxinology | 2017 |
Processing Body Formation Limits Proinflammatory Cytokine Synthesis in Endotoxin-Tolerant Monocytes and Murine Septic Macrophages
C McClure, L Brudecki, ZQ Yao, CE McCall, ME Gazzar |
Journal of Innate Immunity | 2015 |
A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction
YL Chang, TH Chen, YH Wu, GA Chen, TH Weng, PH Tseng, SL Hsieh, SL Fu, CH Lin, CJ Chen, CL Chu, II Chio, TW Mak, NJ Chen |
Journal of Cellular and Molecular Medicine | 2014 |
Upregulating Nonneuronal Cholinergic Activity Decreases TNF Release from Lipopolysaccharide-Stimulated RAW264.7 Cells
Y Lv, S Hu, J Lu, N Dong, Q Liu, M Du, H Zhang |
Mediators of Inflammation | 2014 |
Toll-Like Receptor 4 Stimulation before or after Streptococcus pneumoniae Induced Sepsis Improves Survival and Is Dependent on T-Cells
E Musie, CC Moore, EN Martin, WM Scheld, CC Caldwell |
PloS one | 2014 |
Immunomodulatory effects of azithromycin on the establishment of lipopolysaccharide tolerance in mice
M Bosnar, M Dominis-Kramarić, K Nujić, DS Polančec, N Marjanović, I Glojnarić, VE Haber |
International Immunopharmacology | 2013 |
Endotoxin Tolerance Induced by Lipopolysaccharides Derived from Porphyromonas gingivalis and Escherichia coli: Alternations in Toll-Like Receptor 2 and 4 Signaling Pathway
Y Sun, H Li, MJ Sun, YY Zheng, DJ Gong, Y Xu |
Inflammation | 2013 |
Fractal-like kinetics of intracellular enzymatic reactions: a chemical framework of endotoxin tolerance and a possible non-specific contribution of macromolecular crowding to cross-tolerance
C Vasilescu, M Olteanu, P Flondor, GA Calin |
Theoretical Biology and Medical Modelling | 2013 |
Differences in Organ Dysfunction in Endotoxin-Tolerant Pigs Under Intensive Care Exposed to a Second Hit of Endotoxin :
M Castegren, M Lipcsey, E Söderberg, P Skorup, M Eriksson, A Larsson, J Sjölin |
Shock | 2012 |
MicroRNA in TLR signaling and endotoxin tolerance
MA Nahid, M Satoh, EK Chan |
Cellular and Molecular Immunology | 2011 |
Acute allograft rejection in human liver transplant recipients is associated with signaling through toll-like receptor 4
AG Testro, K Visvanathan, N Skinner, V Markovska, P Crowley, PW Angus, PJ Gow |
Journal of Gastroenterology and Hepatology | 2010 |
IL-12 suppression, enhanced endocytosis and up-regulation of MHC-II and CD80 in dendritic cells during experimental endotoxin tolerance
J Zhang, J Qu, L He |
Acta Pharmacologica Sinica | 2009 |
Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis)
WJ Wiersinga, C Veer, PS van Pangaart, AM Dondorp, NP Day, SJ Peacock, T der Poll |
Critical Care Medicine | 2009 |
Dynamic and selective nucleosome repositioning during endotoxin tolerance
ME Gazzar, T Liu, BK Yoza, CE McCall |
The Journal of biological chemistry | 2009 |
miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY
MA Nahid, KM Pauley, M Satoh, EK Chan |
The Journal of biological chemistry | 2009 |
Calcineurin inactivation leads to decreased responsiveness to LPS in macrophages and dendritic cells and protects against LPS-induced toxicity in vivo
C Jennings, B Kusler, PP Jones |
Innate immunity | 2009 |
Lipopolysaccharide reduces tactile startle response magnitude but not prepulse inhibition in rats: A dose–response examination
AJ Lockey, M Kavaliers, KP Ossenkopp |
Pharmacology Biochemistry and Behavior | 2009 |
Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia
K Kurahashi, T Sawa, M Ota, O Kajikawa, K Hong, TR Martin, JP Wiener-Kronish |
American journal of physiology. Lung cellular and molecular physiology | 2009 |
Chromatin-Specific Remodeling by HMGB1 and Linker Histone H1 Silences Proinflammatory Genes during Endotoxin Tolerance
ME Gazzar, BK Yoza, X Chen, BA Garcia, NL Young, CE McCall |
Molecular and cellular biology | 2009 |
Yam Storage Protein Dioscorins from Dioscorea alata and Dioscorea japonica Exhibit Distinct Immunomodulatory Activities in Mice
PL Lin, KW Lin, CF Weng, KC Lin |
Journal of Agricultural and Food Chemistry | 2009 |
Endotoxemia and endotoxin tolerance in patients with ARDS
K Buttenschoen, M Kornmann, D Berger, G Leder, HG Beger, C Vasilescu |
Langenbeck's Archives of Surgery | 2008 |
Peroxisome proliferator activated receptor γ is not necessary for the development of LPS-induced tolerance in macrophages
B Zingarelli, H Fan, S Ashton, G Piraino, P Mangeshkar, JA Cook |
Immunology | 2008 |
Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia
K Kurahashi, T Sawa, M Ota, O Kajikawa, K Hong, TR Martin, JP Wiener-Kronish |
American journal of physiology. Lung cellular and molecular physiology | 2008 |
Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance
RK Aneja, A Tsung, H Sjodin, JV Gefter, RL Delude, TR Billiar, MP Fink |
Journal of leukocyte biology | 2008 |
Acute Pulmonary Lipopolysaccharide Tolerance Decreases TNF-α without Reducing Neutrophil Recruitment1
S Natarajan, J Kim, DG Remick |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
G9a and HP1 Couple Histone and DNA Methylation to TNFα Transcription Silencing during Endotoxin Tolerance
ME Gazzar, BK Yoza, X Chen, J Hu, GA Hawkins, CE McCall |
The Journal of biological chemistry | 2008 |
Pretreatment With Toll-like Receptor 4 Antagonist Inhibits Lipopolysaccharide-Induced Preterm Uterine Contractility, Cytokines, and Prostaglandins in Rhesus Monkeys
KM Waldorf, D Persing, MJ Novy, DW Sadowsky, MG Gravett |
Reproductive sciences (Thousand Oaks, Calif.) | 2008 |
Acute Pulmonary Lipopolysaccharide Tolerance Decreases TNF-α without Reducing Neutrophil Recruitment
S Natarajan, J Kim, DG Remick |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Gene silencing in severe systemic inflammation
CE McCall, BK Yoza |
American journal of respiratory and critical care medicine | 2007 |
Sepsis
JM O’Brien, NA Ali, SK Aberegg, E Abraham |
The American Journal of Medicine | 2007 |
Epigenetic Silencing of Tumor Necrosis Factor α during Endotoxin Tolerance
ME Gazzar, BK Yoza, JY Hu, SL Cousart, CE McCall |
The Journal of biological chemistry | 2007 |
Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis
JM Cavaillon, M Adib-Conquy |
Critical Care | 2006 |
Systemic inflammation alters the inflammatory response in experimental lipopolysaccharide-induced meningitis
T O'Reilly, C Ostergaard, J Vaxelaire, O Zak |
Clinical & Experimental Immunology | 2006 |
Acute but not chronic stimulation of glial cells in rat spinal cord by systemic injection of lipopolysaccharide is associated with hyperalgesia
LH Guo, HJ Schluesener |
Acta Neuropathologica | 2006 |
Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally
Z Ling, Y Zhu, C Tong, JA Snyder, JW Lipton, PM Carvey |
Experimental Neurology | 2006 |
N -(3-Oxo-acyl)homoserine Lactones Signal Cell Activation through a Mechanism distinct from the Canonical Pathogen-associated Molecular Pattern Recognition Receptor Pathways
VV Kravchenko, GF Kaufmann, JC Mathison, DA Scott, AZ Katz, MR Wood, AP Brogan, M Lehmann, JM Mee, K Iwata, Q Pan, C Fearns, UG Knaus, MM Meijler, KD Janda, RJ Ulevitch |
The Journal of biological chemistry | 2006 |
Influence of the estrous cycle on tolerance development to LPS-induced sickness behaviors in rats
CG Engeland, M Kavaliers, KP Ossenkopp |
Psychoneuroendocrinology | 2006 |
Hyperthermia in Cancer Treatment: A Primer
GF Baronzio, ED Hager |
2006 | |
Deficient control of Trypanosoma cruzi infection in C57BL/6 mice is related to a delayed specific IgG response and increased macrophage production of pro-inflammatory cytokines
AR Pérez, M Tamae-Kakazu, MF Pascutti, E Roggero, E Serra, S Revelli, O Bottasso |
Life Sciences | 2005 |
Fever and lethargy induced by subcutaneous pyrogen infusion in unrestrained rats
I Plessis, D Mitchell, HP Laburn, T Cartmell |
Canadian Journal of Physiology and Pharmacology | 2005 |
Characterization of calves exhibiting a novel inheritable TNF-α hyperresponsiveness to endotoxin: associations with increased pathophysiological complications
TH Elsasser, JW Blum, S Kahl |
Journal of applied physiology | 2005 |
Thymocyte depletion during acuteTrypanosoma cruziinfection in C57BL/6 mice is partly reverted by lipopolysaccharide pretreatment
E Roggero, I Piazzon, I Nepomnaschy, A Perez, A Velikovsky, S Revelli, O Bottasso |
FEMS Immunology & Medical Microbiology | 2004 |
Selective macrophage suppression during sepsis
E Ellaban, G Bolgos, D Remick |
Cellular Immunology | 2004 |
Reviews of Physiology, Biochemistry and Pharmacology
B Gebert, W Fisher, R Haas |
Reviews of Physiology, Biochemistry and Pharmacology | 2004 |
Differential regulation of membrane CD14 expression and endotoxin-tolerance in alveolar macrophages
SM Lin, CW Frevert, O Kajikawa, MM Wurfel, K Ballman, S Mongovin, VA Wong, A Selk, TR Martin |
American journal of respiratory cell and molecular biology | 2004 |
Staphylococcus aureus and Lipopolysaccharide Induce Homologous Tolerance but Heterologous Priming: Role of Interferon-??:
OM Peck, H Fan, GE Tempel, G Teti, PV Halushka, JA Cook |
Shock | 2004 |
Inhibition of a p38/Stress-Activated Protein Kinase-2-Dependent Phosphatase Restores Function of IL-1 Receptor-Associated Kinase-1 and Reverses Toll-Like Receptor 2- and 4-Dependent Tolerance of Macrophages
C Ropert, M Closel, AC Chaves, RT Gazzinelli |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
INNATEIMMUNERESPONSES TOMICROBIALPOISONS: Discovery and Function of the Toll-Like Receptors
B Beutler |
Annual Review of Pharmacology and Toxicology | 2003 |
Pavlovian conditioning of endotoxin-tolerance in rats
R Oberbeck, A Kromm, MS Exton, U Schade, M Schedlowski |
Brain, Behavior, and Immunity | 2003 |
Sex differences in the effects of muramyl dipeptide and lipopolysaccharide on locomotor activity and the development of behavioral tolerance in rats
CG Engeland, M Kavaliers, KP Ossenkopp |
Pharmacology Biochemistry and Behavior | 2003 |
The Strength of Persistent Antigenic Stimulation Modulates Adaptive Tolerance in Peripheral CD4 + T Cells
NJ Singh, RH Schwartz |
Journal of Experimental Medicine | 2003 |
Endotoxin tolerance: is there a clinical relevance?
JM Cavaillon, C Adrie, C Fitting, M Adib-Conquy |
Journal of Endotoxin Research | 2003 |
Endotoxin antagonism: conceptual basis and therapeutic potential
B Beutler |
Expert Opinion on Therapeutic Targets | 2002 |
Endotoxin tolerance: A review
MA West, W Heagy |
Critical Care Medicine | 2002 |
Priming and activation of mouse macrophages by trehalose 6,6â²-dicorynomycolate vesicles fromCorynebacterium glutamicum
M Chami, K Andréau, A Lemassu, JF Petit, C Houssin, V Puech, N Bayan, R Chaby, M Daffé |
FEMS Immunology & Medical Microbiology | 2002 |
Toll receptors, CD14, and macrophage activation and deactivation by LPS
MA Dobrovolskaia, SN Vogel |
Microbes and Infection | 2002 |
Cholera toxin B pretreatment of macrophages and monocytes diminishes their proinflammatory responsiveness to lipopolysaccharide
V Burkart, YE Kim, B Hartmann, I Ghiea, U Syldath, M Kauer, W Fingberg, P Hanifi-Moghaddam, S Müller, H Kolb |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Acute Lung Injury
GD Leikauf, SA McDowell, SC Wesselkamper, WD Hardie, JE Leikauf, TR Korfhagen, DR Prows |
Chest | 2002 |
Invited review: Endotoxin tolerance — current concepts in historical perspective
AS Cross |
Journal of Endotoxin Research | 2002 |
Role of interleukin-10 in monocyte hyporesponsiveness associated with septic shock
T Sfeir, DC Saha, M Astiz, EC Rackow |
Critical Care Medicine | 2001 |
Locomotor activity changes following lipopolysaccharide treatment in mice: a multivariate assessment of behavioral tolerance
CG Engeland, DV Nielsen, M Kavaliers, KP Ossenkopp |
Physiology & Behavior | 2001 |
Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators
MD Lehner, S Morath, KS Michelsen, RR Schumann, T Hartung |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Tlr4: central component of the sole mammalian LPS sensor
B Beutler |
Current Opinion in Immunology | 2000 |
Lipopolysaccharide tolerance and ethanol modulate hepatic nitric oxide production in a gender-dependent manner
JA Spitzer, JJ Spitzer |
Alcohol | 2000 |
PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene
M Rehli, A Poltorak, L Schwarzfischer, SW Krause, R Andreesen, B Beutler |
The Journal of biological chemistry | 2000 |
Endotoxin tolerance protects against local hepatic ischemia/reperfusion injury in the rat
ED Fernández, S Flohé, F Siemers, M Nau, M Ackermann, M Ruwe, FU Schade |
Journal of Endotoxin Research | 2000 |
Immune Response in the Critically Ill
JC Marshall, J Cohen |
2000 | |
ENDOTOXIN TOLERANCE IN RATS: EXPRESSION OF TNF-α, IL-6, IL-10, VCAM-1 AND HSP70 IN LUNG AND LIVER DURING ENDOTOXIN SHOCK
S Flohé, ED Fernández, M Ackermann, T Hirsch, J Börgermann, FU Schade |
Cytokine | 1999 |
NF-kappaB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression
S Kastenbauer, HW Ziegler-Heitbrock |
Infection and immunity | 1999 |
In vitro differentiation and characterization of human peritoneal macrophages from CAPD-Peritonitis patients
M Burger, N Almanasreh, K Bauermeister, HP Knopf, P Schollmeyer, GJ Dobos |
Immunobiology | 1999 |
Augmented enhancement of in vitro production of inflammatory cytokines in peripheral blood mononuclear cells in patients undergoing simultaneous resection of the liver and gastrointestinal tract:
K Sasada, M Miyazaki, K Nakagawa, H Ito, S Ambiru, H Shimizu, N Nakajima |
Critical Care Medicine | 1999 |
Dissociation of IFN-γ from IL-12 and IL-18 production during endotoxin tolerance
N Rayhane, C Fitting, JM Cavaillon |
Journal of Endotoxin Research | 1999 |
Endotoxin-induced cross-tolerance to Gram-positive sepsis
K Guyton, R Bond, C Romeo, R Southern, J Cochran, G Teti, JA Cook |
Journal of Endotoxin Research | 1999 |
LPS pretreatment of mouse peritoneal macrophages differentially modulates TNFα and iNOS expression
N Hirohashi, MG Lei, DC Morrison |
Journal of Endotoxin Research | 1999 |
Cytokines in Severe Sepsis and Septic Shock
H Redl, G Schlag |
1999 | |
NF-κB1 (p50) Is Upregulated in Lipopolysaccharide Tolerance and Can Block Tumor Necrosis Factor Gene Expression
SH Kaufmann, S Kastenbauer, HW Ziegler-Heitbrock |
Infection and immunity | 1999 |
Regulation of an essential innate immune response by the p50 subunit of NF-kappaB
J Bohuslav, VV Kravchenko, GC Parry, JH Erlich, S Gerondakis, N Mackman, RJ Ulevitch |
Journal of Clinical Investigation | 1998 |
Effect of Endotoxin on Cytokine Production and Cell Dynamics in Mice
A Estrada, AV Kessel, CH Yun, B Li |
Immunopharmacology and Immunotoxicology | 1998 |
Tolerance to Pyrogens
E Zeisberger, J Roth |
Annals of the New York Academy of Sciences | 1998 |
Anti-CD14 mAb treatment provides therapeutic benefit after in vivo exposure to endotoxin
J Schimke, J Mathison, J Morgiewicz, RJ Ulevitch |
Proceedings of the National Academy of Sciences | 1998 |
Metabolic and inflammatory responses after laparoscopic and open inguinal hernia repair
K Akhtar, ID Kamalky-asl, WR Lamb, I Laing, L Walton, RC Pearson, NR Parrott |
Annals of the Royal College of Surgeons of England | 1998 |
Inflammatory cytokines (IL-1α, TNF-α) and LPS modulate the Ca 2+ signaling pathway in osteoblasts
VK Tam, S Schotland, J Green |
American journal of physiology. Cell physiology | 1998 |
Avian macrophage metabolism
RR Dietert, KA Golemboski |
Poultry science | 1998 |
Nitric Oxide (NO) and Oxygen Radicals, but Not Prostaglandins, Modulate Fever
D Weihrauch, W Riedel |
Annals of the New York Academy of Sciences | 1997 |
A comparative analysis of cytokine production and tolerance induction by bacterial lipopeptides, lipopolysaccharides and Staphyloccous aureus in human monocytes
M Kreutz, U Ackermann, S Hauschildt, SW Krause, D Riedel, W Bessler, R Andreesen |
Immunology | 1997 |
Involvement of the membrane form of tumour necrosis factor-alpha in lipopolysaccharide-induced priming of mouse peritoneal macrophages for enhanced nitric oxide response to lipopolysaccharide
P Ancuta, H Fahmi, JF Pons, KL Blay, R Chaby |
Immunology | 1997 |
Modulation of the biological activities of meningococcal endotoxins by association with outer membrane proteins is not inevitably linked to toxicity
EK Quakyi, HD Hochstein, CM Tsai |
Infection and immunity | 1997 |
Perioperative Anti-endotoxin Strategies
AP Houdijk, C Meijer, MA Cuesta, S Meyer, PA van Leeuwen |
Scandinavian Journal of Gastroenterology | 1997 |
Interleukin-10 is downregulated in mononuclear cells from endotoxin tolerant humans
R Flach, S Flohé, M Laschinski, K Hofmann, E Kreuzfelder, FU Schade |
Journal of Endotoxin Research | 1997 |
Lack of cross tolerance between LPS and muramyl dipeptide in induction of circulating TNF-α and IL-6 in guinea pigs
J Roth, T Aslan, B Störr, E Zeisberger |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 1997 |
Peritoneal macrophages from endotoxin-tolerant mice produce an inhibitor of tumor necrosis factor α synthesis and protect against endotoxin shock
R Flach, FU Schade |
Journal of Endotoxin Research | 1997 |
Preexposure of mouse peritoneal macrophages to lipopolysaccharide and other stimuli enhances the nitric oxide response to secondary stimuli
H Fahmi, P Ancuta, S Perrier, R Chaby |
Inflammation Research | 1996 |
Biochemistry and cell biology of bacterial endotoxins
O Holst, AJ Ulmer, H Brade, HD Flad, ET Rietschel |
FEMS Immunology & Medical Microbiology | 1996 |
Correlation between acute physiology and chronic health evaluation (APACHE) III score and immunological parameters in critically ill patients with sepsis
MA Rogy, HS Oldenburg, S Coyle, R Trousdale, LL Moldawer, SF Lowry |
British Journal of Surgery | 1996 |
Induction of early-phase endotoxin tolerance in horses
GK Allen, C Campbell-Beggs, JA Robinson, RJ Johnson, EM Green |
Equine Veterinary Journal | 1996 |
Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1
DY Wu, GV Kalpana, SP Goff, WH Schubach |
Journal of virology | 1996 |
Low-dose lipopolysaccharide (LPS) pretreatment of mouse macrophages modulates LPS-dependent interleukin-6 production in vitro
N Hirohashi, DC Morrison |
Infection and immunity | 1996 |
Monocyte response to bacterial toxins, expression of cell surface receptors, and release of anti-inflammatory cytokines during sepsis
M Astiz, D Saha, D Lustbader, R Lin, E Rackow |
Journal of Laboratory and Clinical Medicine | 1996 |
Endotoxin-tolerant mice produce an inhibitor of tumor necrosis factor synthesis
FU Schade, J Schlegel, K Hofmann, H Brade, R Flach |
Journal of Endotoxin Research | 1996 |
Obstructive jaundice causes reduced expression of polymorphonuclear leucocyte adhesion molecules and a depressed response to bacterial wall products in vitro
S Plusa, N Webster, J Primrose |
Gut | 1996 |
Pathology of Septic Shock
ET Rietschel, H Wagner |
1996 | |
ARDS Acute Respiratory Distress in Adults
TW Evans, C Haslett |
1996 | |
Controversies surrounding current therapies for sepsis syndrome
J Cavaillon |
Bulletin de l'Institut Pasteur | 1995 |
Prevention of experimental endotoxin shock by a monocyte activator
B Passlick, MO Labeta, JR Izbicki, P Ostertag, T Löffler, M Siebeck, U Pichlmeier, L Schweiberer, HW Ziegler-Heitbrock |
Antimicrobial agents and chemotherapy | 1995 |
Tolerance to Lipopolysaccharide in Human Blood Monocytes
HW Ziegler-Heitbrock, M Frankenberger, A Wedel |
Immunobiology | 1995 |
Pretreatment of normal humans with monophosphoryl lipid A induces tolerance to endotoxin: A prospective, double-blind, randomized, controlled trial
ME Astiz, EC Rackow, JG Still, ST Howell, A Cato, KB von Eschen, JT Ulrich, JA Rudbach, G McMahon, R Vargas, W Stern |
Critical Care Medicine | 1995 |
Monophosphoryl Lipid A and Endotoxin Tolerance:
ME Astiz, EC Rackow |
Critical Care Medicine | 1995 |
The release of endotoxin, TNF and IL-6 during the antibiotic treatment of experimental Gram-negative sepsis
AS Dofferhoff, H Potthoff, VJ Bom, HL Bartels, HG Vries-Hospers, J Bijzet, J Weits, W Buurman, RP Bleichrodt |
Journal of Endotoxin Research | 1995 |
Role of Cytokines in Patients on Dialysis
BJ Pereira, CA Dinarello |
The International Journal of Artificial Organs | 1995 |
Therapeutic Antibodies
J Landon, T Chard |
1995 | |
Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock
A Marchant, ML Alegre, A Hakim, G Piérard, G Marécaux, G Friedman, DD Groote, RJ Kahn, JL Vincent, M Goldman |
Journal of Clinical Immunology | 1995 |
Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri
A Zychlinsky, C Fitting, JM Cavaillon, PJ Sansonetti |
Journal of Clinical Investigation | 1994 |
Tumour necrosis factor and eicosanoid production from monocytes exposed to HTVin vitro
J Skøt, P Kabrit, JE Hansen, JO Nielsen, JD Lundgren, L Nielsen |
APMIS | 1994 |
Expression from Leukocyte Integrin Promoters in Retroviral Vectors
TR Bauer, WR Osborne, WW Kwok, DD Hickstein |
Human Gene Therapy | 1994 |
Protein phosphorylation in murine peritoneal macrophages induced by infection with Salmonella species
S Saito, H Shinomiya, M Nakano |
Infection and immunity | 1994 |
Attenuation of fever and release of cytokines after repeated injections of lipopolysaccharide in guinea-pigs
J Roth, JL McClellan, MJ Kluger, E Zeisberger |
The Journal of Physiology | 1994 |
A labile transcriptional repressor modulates endotoxin tolerance
KE LaRue, CE McCall |
Journal of Experimental Medicine | 1994 |
Interleukin-8 and Related Chemotactic Cytokines
M Baggiolini, B Moser, I Clark-Lewis |
Chest | 1994 |
Endotoxin tolerance is not a LPS-specific phenomenon: partial mimicry with IL-1, IL-10 and TGFβ
JM Cavaillon, C Pitton, C Fitting |
Journal of Endotoxin Research | 1994 |
Temperature Regulation
AS Milton |
1994 | |
Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers
HW Ziegler-Heitbrock, A Wedel, W Schraut, M Ströbel, P Wendelgass, T Sternsdorf, PA Bäuerle, JG Haas, G Riethmüller |
The Journal of biological chemistry | 1994 |
Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome
CE McCall, LM Grosso-Wilmoth, K LaRue, RN Guzman, SL Cousart |
Journal of Clinical Investigation | 1993 |
Lipopolysaccharide (LPS) recognition in macrophages. Participation of LPS-binding protein and CD14 in LPS-induced adaptation in rabbit peritoneal exudate macrophages
J Mathison, E Wolfson, S Steinemann, P Tobias, R Ulevitch |
Journal of Clinical Investigation | 1993 |
Pharmacokinetics and immunomodulatory effects on monocytes during prolonged therapy with liposomal muramyltripeptide
R Landmann, R Obrist, H Denz, C Ludwig, H Frost, M Wesp, C Rordorf, H Towbin, D Gygax, L Tarcsay, JP Obrecht |
Biotherapy | 1993 |
Pre-exposure of murine macrophages to lipopolysaccharide inhibits the induction of nitric oxide synthase and reduces leishmanicidal activity
A Severn, D Xu, J Doyle, LM Leal, CA O'Donnell, SJ Brett, DW Moss, FY Liew |
European Journal of Immunology | 1993 |
A critical role for monocytes and CD14 in endotoxin-induced endothelial cell activation
J Pugin, RJ Ulevitch, PS Tobias |
Journal of Experimental Medicine | 1993 |
CD14 and tolerance to lipopolysaccharide: biochemical and functional analysis
MO Labeta, JJ Durieux, G Spagnoli, N Fernandez, J Wijdenes, R Herrmann |
Immunology | 1993 |
Lipopolysaccharide-induced selective priming effects on tumor necrosis factor alpha and nitric oxide production in mouse peritoneal macrophages
X Zhang, DC Morrison |
Journal of Experimental Medicine | 1993 |
Differential regulation of cytokine production in lipopolysaccharide tolerance in mice
A Erroi, G Fantuzzi, M Mengozzi, M Sironi, SF Orencole, BD Clark, CA Dinarello, A Isetta, P Gnocchi, M Giovarelli |
Infection and immunity | 1993 |
Expression and Regulation of Tumor Necrosis Factor in Macrophages from Cystic Fibrosis Patients
KD Pfeffer, TP Huecksteadt, JR Hoidal |
American journal of respiratory cell and molecular biology | 1993 |
Recombinant Cytokines and Pulmonary Host Defense
JK Kolls, S Nelson, WR Summer |
The American Journal of the Medical Sciences | 1993 |
Host Defense Dysfunction in Trauma, Shock and Sepsis
E Faist, JL Meakins, FW Schildberg |
1993 | |
Pathophysiology of Shock, Sepsis, and Organ Failure
G Schlag, H Redl |
1993 | |
Activated macrophages depress the contractility of rabbit carotids via an L-arginine/nitric oxide-dependent effector mechanism. Connection with amplified cytokine release
C Bernard, B Szekely, I Philip, E Wollman, D Payen, A Tedgui |
Journal of Clinical Investigation | 1992 |
Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs
TR Martin, JC Mathison, PS Tobias, DJ Letúrcq, AM Moriarty, RJ Maunder, RJ Ulevitch |
Journal of Clinical Investigation | 1992 |
Cytokines tumor necrosis factor and interleukin-6 in experimental biliary obstruction in mice
MH Bemelmans, DJ Gouma, JW Greve, WA Buurman |
Hepatology | 1992 |
Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein
JD Lee, K Kato, PS Tobias, TN Kirkland, RJ Ulevitch |
Journal of Experimental Medicine | 1992 |
In vitro desensitization to lipopolysaccharide suppresses tumour necrosis factor, interleukin-1 and interleukin-6 gene expression in a similar fashion
HW Ziegler-Heitbrock, M Blumenstein, E Käfferlein, D Kieper, I Petersmann, S Endres, WA Flegel, H Northoff, G Riethmüller, JG Haas |
Immunology | 1992 |
Protection against lethal pneumococcal septicemia in pigs is associated with decreased levels of interleukin-6 in blood
HW Ziegler-Heitbrock, B Passlick, E Käfferlein, PG Coulie, JR Izbicki |
Infection and immunity | 1992 |
Effects of gamma interferon on release of tumor necrosis factor alpha from lipopolysaccharide-tolerant human monocyte-derived macrophages
M Matic, SR Simon |
Infection and immunity | 1992 |
Sepsis induces an early increased spontaneous release of hepatocellular stimulatory factor (interleukin-6) by Kupffer cells in both endotoxin tolerant and intolerant mice
A Ayala, MM Perrin, P Wang, IH Chaudry |
Journal of Surgical Research | 1992 |
Pathophysiology of pulmonary defense mechanisms
CM Mason, WR Summer, S Nelson |
Journal of Critical Care | 1992 |
Participation of Lipopolysaccharide-binding Protein in Lipopolysaccharide-dependent Macrophage Activation
PS Tobias, J Mathison, D Mintz, JD Lee, V Kravchenko, K Kato, J Pugin, RJ Ulevitch |
American journal of respiratory cell and molecular biology | 1992 |
Function of lipopolysaccharide (LPS)-binding protein (LBP) and CD14, the receptor for LPS/LBP complexes: a short review
RR Schumann |
Research in Immunology | 1992 |
In Vitro Tumor Necrosis Factor- α Secretion by Monocytes from Patients with Cystic Fibrosis
JS Elborn, D Norman, FM Delamere, DJ Shale |
American journal of respiratory cell and molecular biology | 1992 |
Molecular cloning of porcine alveolar macrophage-derived neutrophil chemotactic factors I and II: identification of porcine IL-8 and another intercrine-.alpha. protein
RB Goodman, DC Foster, SL Mathewes, SG Osborn, JL Kuijper, JW Forstrom, TR Martin |
Biochemistry | 1992 |
Dysregulation of in vitro cytokine production by monocytes during sepsis
C Munoz, J Carlet, C Fitting, B Misset, JP Blériot, JM Cavaillon |
Journal of Clinical Investigation | 1991 |
Regulation of tumor necrosis factor (TNF) release by murine peritoneal macrophages: role of cell stimulation and specific phagocytic plasma membrane receptors
M Stein, S Gordon |
European Journal of Immunology | 1991 |
Effect of cytokines and lipopolysaccharide on CD14 antigen expression in human monocytes and macrophages
R Landmann, C Ludwig, R Obrist, JP Obrecht |
Journal of Cellular Biochemistry | 1991 |
Tumor necrosis factor release from lipopolysaccharide-stimulated human monocytes: Lipopolysaccharide tolerance in vitro
M Matic, SR Simon |
Cytokine | 1991 |
Time course of IL-6 and TNFα release during endotoxin-induced endotoxin tolerance in rats
S Flohé, PC Heinrich, J Schneider, A Wendel, L Flohé |
Biochemical Pharmacology | 1991 |
Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides
FS Hagen, FJ Grant, JL Kuijper, CA Slaughter, CR Moomaw, K Orth, PJ O'Hara, RS Munford |
Biochemistry | 1991 |
Polymorphonuclear neutrophil contribution to induced tolerance to bacterial lipopolysaccharide
J Barroso-Aranda, GW Schmid-Schönbein, BW Zweifach, JC Mathison |
Circulation research | 1991 |
Identification of two neutrophil chemotactic peptides produced by porcine alveolar macrophages
RB Goodman, JW Forstrom, SG Osborn, EY Chi, TR Martin |
The Journal of biological chemistry | 1991 |
Response : CD14 and Immune Response to Lipopolysaccharide
SD Wright |
Science | 1991 |
Structure and Function of Lipopolysaccharide Binding Protein
RR Schumann, SR Leong, GW Flaggs, PW Gray, SD Wright, JC Mathison, PS Tobias, RJ Ulevitch |
Science | 1990 |