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Citations to this article

Induction of excessive B cell proliferation and differentiation by an in vitro stimulus in culture in human systemic lupus erythematosus.
N Suzuki, T Sakane
N Suzuki, T Sakane
Published March 1, 1989
Citation Information: J Clin Invest. 1989;83(3):937-944. https://doi.org/10.1172/JCI113979.
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Research Article

Induction of excessive B cell proliferation and differentiation by an in vitro stimulus in culture in human systemic lupus erythematosus.

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Abstract

B cell hyperactivity present in the body in patients with systemic lupus erythematosus (SLE) can be detectable via almost any measure of B cell function. Nonetheless, the basis for the B cell hyperactivity is difficult to study in vitro. In this study, we have obtained the resting B cells from patients with entirely inactive SLE by collecting them sedimenting in a high density fraction on a Percoll density gradient. These resting SLE B cells proliferated in vitro at a higher rate than normal B cells when exposed to Staphylococcus aureus Cowan I (SAC). In addition, significant proliferation was observed earlier in the course of culture in SLE patients than in normal controls. Moreover, the SLE resting B cells, once triggered by SAC produced abnormally high numbers of immunoglobulin-secreting cells in response to T cell-derived soluble factors. There was less frequency of circulating Leu 1+ B cells in the SLE patients than in normal controls. Moreover, not only Leu 1+ B cells but also Leu 1- B cells of SLE patients were more responsive to SAC than those of normal controls. The results indicate that the B cell hyperactivity in human SLE can be induced by in vitro stimuli, and may not be limited to the Leu 1+ B cell subset.

Authors

N Suzuki, T Sakane

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Total citations by year

Year: 2024 2022 2020 2018 2010 2008 2006 2004 2003 2001 1997 1994 1993 1992 1991 1990 Total
Citations: 1 2 1 1 1 3 1 1 1 1 1 3 2 7 4 2 32
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2022 (2)

Title and authors Publication Year
B cells in systemic lupus erythematosus: Targets of new therapies and surveillance tools.
Parodis I, Gatto M, Sjöwall C
Frontiers in Medicine 2022
Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature.
Shimizu Y, Ntege EH, Sunami H, Inoue Y
Regenerative Therapy 2022

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