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Citations to this article

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
Svetlana Mojsov, … , Gordon C. Weir, Joel F. Habener
Svetlana Mojsov, … , Gordon C. Weir, Joel F. Habener
Published February 1, 1987
Citation Information: J Clin Invest. 1987;79(2):616-619. https://doi.org/10.1172/JCI112855.
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Research Article Article has an altmetric score of 51

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas

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Abstract

Insulin secretion is controlled by a complex set of factors that include not only glucose but amino acids, catecholamines, and intestinal hormones. We report that a novel glucagon-like peptide, co-encoded with glucagon in the glucagon gene is a potent insulinotropic factor. The glucagon gene encodes a proglucagon that contains in its sequence glucagon and additional glucagon-like peptides (GLPs). These GLPs are liberated from proglucagon in both the pancreas and intestines. GLP-I exists in at least two forms: 37 amino acids GLP-I(1-37), and 31 amino acids, GLP-I(7-37). We studied the effects of synthetic GLP-Is on insulin secretion in the isolated perfused rat pancreas. In the presence of 6.6 mM glucose, GLP-I(7-37) is a potent stimulator of insulin secretion at concentrations as low as 5 X 10(-11) M (3- to 10-fold increases over basal). GLP-I(1-37) had no effect on insulin secretion even at concentrations as high as 5 X 10(-7) M. The earlier demonstration of specific liberation of GLP-I(7-37) in the intestine and pancreas, and the magnitude of the insulinotropic effect at such low concentrations, suggest that GLP-I(7-37) participates in the physiological regulation of insulin secretion. Images

Authors

Svetlana Mojsov, Gordon C. Weir, Joel F. Habener

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1985 1964 Total
Citations: 9 23 12 13 21 12 24 25 18 31 19 35 24 15 130 39 17 23 16 18 14 13 12 9 11 16 11 13 10 18 17 12 13 18 11 12 11 10 5 1 1 762
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Citations to this article in year 2006 (18)

Title and authors Publication Year
Gastrointestinal hormones regulating appetite
O Chaudhri, C Small, S Bloom
Philosophical Transactions of the Royal Society B: Biological Sciences 2006
Major contributions of comparative endocrinology to the development and exploitation of the incretin concept
JM Conlon, S Patterson, PR Flatt
Journal of Experimental Zoology Part A: Comparative Experimental Biology 2006
Gut?Brain Axis: Regulation of Glucose Metabolism
AC Heijboer, H Pijl, AM van Hoek, LM Havekes, JA Romijn, EP Corssmit
Journal of Neuroendocrinology 2006
Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005
JJ Holst
Diabetologia 2006
Glucagon-Like Peptide-2: Update of the Recent Clinical Trials
PB Jeppesen
Gastroenterology 2006
Newer therapeutic options for children with diabetes mellitus: theoretical and practical considerations
GS Jeha, RA Heptulla
Pediatric Diabetes 2006
Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures
CM Mack, CX Moore, CM Jodka, S Bhavsar, JK Wilson, JA Hoyt, JL Roan, C Vu, KD Laugero, DG Parkes, AA Young
International Journal of Obesity 2006
“The next big thing” in diabetes: clinical progress on DPP-IV inhibitors
TW von Geldern, JM Trevillyan
Drug Development Research 2006
Increased insulin resistance and β cell activity in patients with Crohn's disease
N Bregenzer, A Hartmann, U Strauch, J Schölmerich, T Andus, LC Bollheimer
Inflammatory Bowel Diseases 2006
Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1)
RD Wideman, IL Yu, TD Webber, CB Verchere, JD Johnson, AT Cheung, TJ Kieffer
Proceedings of the National Academy of Sciences 2006
GLP-1 based therapy for type 2 diabetes
DK Arulmozhi, B Portha
European Journal of Pharmaceutical Sciences 2006
Using Evolutionary Information and Ancestral Sequences to Understand the Sequence–Function Relationship in GLP-1 Agonists
M Skovgaard, JT Kodra, DX Gram, SM Knudsen, D Madsen, DA Liberles
Journal of Molecular Biology 2006
Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin
T Adachi, T Tanaka, K Takemoto, T Koshimizu, A Hirasawa, G Tsujimoto
Biochemical and Biophysical Research Communications 2006
Liraglutide, a Long-Acting Glucagon-Like Peptide-1 Analog, Reduces Body Weight and Food Intake in Obese Candy-Fed Rats, Whereas a Dipeptidyl Peptidase-IV Inhibitor, Vildagliptin, Does Not
K Raun, P Voss, CF Gotfredsen, V Golozoubova, B Rolin, LB Knudsen
Diabetes 2006
Pancreatic and Extrapancreatic Effects of Gastric Inhibitory Polypeptide
Y Yamada, K Miyawaki, K Tsukiyama, N Harada, C Yamada, Y Seino
Diabetes 2006
Physiology of the Gastrointestinal Tract
DJ Drucker
Physiology of the Gastrointestinal Tract 2006
Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action
V Ionut, IF Liberty, K Hucking, M Lottati, D Stefanovski, D Zheng, RN Bergman
American journal of physiology. Endocrinology and metabolism 2006
Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors
Z Pei, X Li, K Longenecker, TW von Geldern, PE Wiedeman, TH Lubben, BA Zinker, K Stewart, SJ Ballaron, MA Stashko, AK Mika, DW Beno, M Long, H Wells, AJ Kempf-Grote, DJ Madar, TS McDermott, L Bhagavatula, MG Fickes, D Pireh, LR Solomon, MR Lake, R Edalji, EH Fry, HL Sham, JM Trevillyan
Journal of Medicinal Chemistry 2006

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