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Research Article Free access | 10.1172/JCI112806

Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor.

C A Sieff, S Tsai, and D V Faller

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Published January 1, 1987 - More info

Published in Volume 79, Issue 1 on January 1, 1987
J Clin Invest. 1987;79(1):48–51. https://doi.org/10.1172/JCI112806.
© 1987 The American Society for Clinical Investigation
Published January 1, 1987 - Version history
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Abstract

Monokine-stimulated endothelial cells are known to produce both burst- and colony-stimulating activities, but neither the nature of the monokine nor the hematopoietic growth factor(s) produced is known. We show by mRNA analysis that an immortalized line of human endothelial cells constitutively produce granulocyte-macrophage colony-stimulating factor. Furthermore, interleukin 1 and tumor necrosis factor induce early passage human umbilical endothelial cells to produce the same growth factor.

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