JCI - Citations to 1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation.

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1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation.

D D Bikle, … , E Gee, P Elias

D D Bikle, … , E Gee, P Elias

Published August 1, 1986
Citation Information: J Clin Invest. 1986;78(2):557-566. https://doi.org/10.1172/JCI112609.

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Citations to this article (209)

Title and authors	Publication	Year
Causal effects of retinol and vitamin D on tongue cancer risk: a mendelian randomization study Zhang J, Lou Y, Chen H, Huang X	BMC Oral Health	2025
Various Cellular Components and Its Signaling Cascades Through the Involvement of Signaling Messengers in Keratinocyte Differentiation Kim HJ, Yang D, Hong JH	Antioxidants	2025
Positive Association of Urinary Dimethylarsinic Acid (DMA(V)) with Serum 25(OH)D in Adults Living in an Area of Water-Borne Arsenicosis in Shanxi, China. Zhang K, Yin Y, Lv M, Zhang X, Zhang M, Cui J, Guan Z, Liu X, Liu Y, Gao Y, Yang Y	Toxics	2024
Vitamin D in Cutaneous T-Cell Lymphoma. Ødum AF, Geisler C	Cells	2024
FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation Zhang P, Yang J, Liu X, Huang C, Tao Y, Shen P, Bai Z, Xiao C, Zhou L, Li G, Zhang L, Zhou W, Gao Y	Cell Death and Disease	2024
1,25-Dihydroxyvitamin D3 Suppresses UV-Induced Poly(ADP-Ribose) Levels in Primary Human Keratinocytes, as Detected by a Novel Whole-Cell ELISA De Silva WG, Sequeira VB, Yang C, Dixon KM, Holland AJ, Mason RS, Rybchyn MS	International journal of molecular sciences	2024
The Over-Irradiation Metabolite Derivative, 24-Hydroxylumister-ol(3), Reduces UV-Induced Damage in Skin. De Silva WGM, McCarthy BY, Han J, Yang C, Holland AJA, Stern H, Dixon KM, Tang EKY, Tuckey RC, Rybchyn MS, Mason RS	Metabolites	2023
Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy. Brożyna AA, Slominski RM, Nedoszytko B, Zmijewski MA, Slominski AT	International journal of molecular sciences	2022
Bovine Immunity and Vitamin D₃: An Emerging Association in Johne's Disease. Wherry TLT, Stabel JR	Microorganisms	2022
Oral and Topical Vitamin D, Sunshine, and UVB Phototherapy Safely Control Psoriasis in Patients with Normal Pretreatment Serum 25-Hydroxyvitamin D Concentrations: A Literature Review and Discussion of Health Implications PJ McCullough, WP McCullough, D Lehrer, JB Travers, SJ Repas	Nutrients	2021
Topical Application of Vitamin D3-Loaded Hybrid Nanosystem to Offset Imiquimod-Induced Psoriasis SS Pukale, A Mittal, D Chitkara	AAPS PharmSciTech	2021
Vitamin D receptor and 1α-hydroxylase are highly expressed in lungs of mice infected with H9N2 avian influenza viruses P Lian, Y Bai, J Li, H Wang, X Niu, Z Zhang, H Li, L Zhao, J Qiao	The Journal of Steroid Biochemistry and Molecular Biology	2021
Breastfeeding and vitamin D. Heo JS, Ahn YM, Kim AE, Shin SM		2021
A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression MB Lowry, C Guo, Y Zhang, ML Fantacone, IE Logan, Y Campbell, W Zhang, M Le, AK Indra, G Ganguli-Indra, J Xie, RL Gallo, HP Koeffler, AF Gombart	The Journal of Steroid Biochemistry and Molecular Biology	2020
Sunlight, Vitamin D and Skin Cancer J Reichrath		2020
Sunlight, Vitamin D and Skin Cancer J Reichrath		2020
Sunlight, Vitamin D and Skin Cancer J Reichrath		2020
Sunlight, Vitamin D and Skin Cancer J Reichrath		2020
Sunlight, Vitamin D and Skin Cancer J Reichrath		2020
Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine R Sato, C Makino-Okamura, Q Lin, M Wang, JE Shoemaker, T Kurosaki, H Fukuyama	International Immunology	2020
Multiple Sclerosis: Lipids, Lymphocytes, and Vitamin D. Hayes CE, Ntambi JM	Immunometabolism	2020
Awareness of Vitamin D Deficiency among the General Population in Jeddah, Saudi Arabia LH Alamoudi, RZ Almuteeri, ME Al-Otaibi, DA Alshaer, SK Fatani, MM Alghamdi, OY Safdar	Journal of nutrition and metabolism	2019
Assessing the Effect of Vitamin D Replacement on Basal Cell Carcinoma Occurrence and Recurrence Rates in Patients with Vitamin D Deficiency B Ince, ME Yildirim, M Dadaci	Hormones and Cancer	2019
UV increases skin-derived 1α,25-dihydroxyvitamin D3 production, leading to MMP-1 expression by altering the balance of vitamin D and cholesterol synthesis from 7-dehydrocholesterol MH Shin, Y Lee, MK Kim, DH Lee, JH Chung	The Journal of Steroid Biochemistry and Molecular Biology	2019
Physiologic and pathophysiologic roles of extra renal CYP27b1: Case report and review DD Bikle, S Patzek, Y Wang	Bone Reports	2018
Vitamin D and kidney disease L Keung, F Perwad	Bone Reports	2018
Does the environment influence multiple sclerosis pathogenesis via UVB light and/or induction of vitamin D? J Breuer, K Loser, N Mykicki, H Wiendl, N Schwab	Journal of Neuroimmunology	2018
Vitamin D receptor polymorphisms and melanoma (Review) A Vasilovici, L Grigore, L Ungureanu, O Fechete, E Candrea, A Trifa, S Vișan, S Șenilă, R Cosgarea	Oncology Letters	2018
Vitamin D Assays. Bikle DD	Frontiers of hormone research	2018
Ultraviolet Light in Human Health, Diseases and Environment SI Ahmad	Ultraviolet Light in Human Health, Diseases and Environment	2017
Ultraviolet Light in Human Health, Diseases and Environment SI Ahmad	Ultraviolet Light in Human Health, Diseases and Environment	2017
Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions M Mihajlovic, M Fedecostante, M Oost, S Steenhuis, E Lentjes, I Maitimu-Smeele, M Janssen, L Hilbrands, R Masereeuw	International journal of molecular sciences	2017
Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status? D Bikle, R Bouillon, R Thadhani, I Schoenmakers	The Journal of Steroid Biochemistry and Molecular Biology	2017
Calcitriol regulates immune genes CD14 and CD180 to modulate LPS responses in human trophoblasts MS Longtine, S Cvitic, BN Colvin, B Chen, G Desoye, DM Nelson	Reproduction	2017
Vitamin D Prevents Sunburn: Tips for the Summer? DD Bikle	Journal of Investigative Dermatology	2017
Examination of VDR/RXR/DRIP205 Interaction, Intranuclear Localization, and DNA Binding in Ras-Transformed Keratinocytes and Its Implication for Designing Optimal Vitamin D Therapy in Cancer S Jusu, JF Presley, C Williams, SK Das, B Jean-Claude, R Kremer	Endocrinology	2017
Low vitamin D-modulated calcium-regulating proteins in psoriasis vulgaris plaques: S100A7 overexpression depends on joint involvement S Cubillos, J Norgauer	International journal of molecular medicine	2016
Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer DD Bikle, Y Jiang, T Nguyen, Y Oda, C Tu	Frontiers in physiology	2016
Genetic disorders of Vitamin D biosynthesis and degradation WL Miller	The Journal of Steroid Biochemistry and Molecular Biology	2016
Inborn Metabolic Diseases JM Saudubray, MR Baumgartner, J Walter	Inborn Metabolic Diseases	2016
Vitamin D Actions on CD4+ T Cells in Autoimmune Disease CE Hayes, SL Hubler, JR Moore, LE Barta, CE Praska, FE Nashold	Frontiers in immunology	2015
On the role of skin in the regulation of local and systemic steroidogenic activities AT Slominski, PR Manna, RC Tuckey	Steroids	2015
Activation of Vitamin D Regulates Response of Human Bronchial Epithelial Cells to Aspergillus fumigatus in an Autocrine Fashion P Li, T Wu, X Su, Y Shi	Mediators of Inflammation	2015
Admission vitamin D status is associated with discharge destination in critically ill surgical patients K Brook, CA Camargo, KB Christopher, SA Quraishi	Annals of Intensive Care	2015
Antitumor Effects of Vitamin D Analogs on Hamster and Mouse Melanoma Cell Lines in Relation to Melanin Pigmentation T Wasiewicz, P Szyszka, M Cichorek, Z Janjetovic, R Tuckey, A Slominski, M Zmijewski	International journal of molecular sciences	2015
Pediatric Nephrology ED Avner, WE Harmon, P Niaudet, N Yoshikawa, F Emma, S Goldstein	Pediatric Nephrology	2015
The role of nuclear hormone receptors in cutaneous wound repair: NUCLEAR RECEPTORS AND WOUND REPAIR S Rieger, H Zhao, P Martin, K Abe, TS Lisse	Cell Biochemistry and Function	2014
Novel activities of CYP11A1 and their potential physiological significance AT Slominski, W Li, TK Kim, I Semak, J Wang, JK Zjawiony, RC Tuckey	The Journal of Steroid Biochemistry and Molecular Biology	2014
Vitamin D Metabolism, Mechanism of Action, and Clinical Applications DD Bikle	Chemistry & Biology	2014
Vitamin D receptor, a tumor suppressor in skin 1 DD Bikle	Canadian Journal of Physiology and Pharmacology	2014
Effect of Vitamin D Receptor Knockout on Cornea Epithelium Wound Healing and Tight Junctions RA Elizondo, Z Yin, X Lu, MA Watsky	Investigative ophthalmology & visual science	2014
The Vitamin D Receptor as Tumor Suppressor in Skin Bikle DD	Advances in experimental medicine and biology	2014
In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland AT Slominski, TK Kim, HZ Shehabi, EK Tang, HA Benson, I Semak, Z Lin, CR Yates, J Wang, W Li, RC Tuckey	Molecular and Cellular Endocrinology	2014
Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells E Munetsuna, R Kawanami, M Nishikawa, S Ikeda, S Nakabayashi, K Yasuda, M Ohta, M Kamakura, S Ikushiro, T Sakaki	Molecular and Cellular Endocrinology	2014
Vitamin D and Skin Cancer EM Burns, CA Elmets, N Yusuf	Photochemistry and Photobiology	2014
Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways Andrzej T. Slominski, Michal A. Zmijewski, Igor Semak, Blazej Zbytek, Alexander Pisarchik, Wei Li, Jordan Zjawiony, Robert C. Tuckey	Anti-cancer agents in medicinal chemistry	2014
Pathogenesis and Treatment of Acne and Rosacea CC Zouboulis, AD Katsambas, AM Kligman		2014
FGF-23 Regulates CYP27B1 Transcription in the Kidney and in Extra-Renal Tissues A Chanakul, MY Zhang, A Louw, HJ Armbrecht, WL Miller, AA Portale, F Perwad, JC Dussaule	PloS one	2013
Vitamin D metabolism in human bone marrow stromal (mesenchymal stem) cells S Geng, S Zhou, Z Bi, J Glowacki	Metabolism	2013
Genetics of Bone Biology and Skeletal Disease CS Kovacs	Genetics of Bone Biology and Skeletal Disease	2013
Seldin and Giebisch's The Kidney CJ Cooper, LD Dworkin, WL Henrich	Seldin and Giebisch's The Kidney	2013
Extraskeletal effects and manifestations of Vitamin D deficiency RK Visweswaran, H Lekha	Indian journal of endocrinology and metabolism	2013
The Effect of Chrysin on the Transcriptional Activity of Vitamin D Receptor in Human Keratinocytes JH Choo, SH Lee	Journal of the Society of Cosmetic Scientists of Korea	2013
PTH/PTHrP and Vitamin D Control Antimicrobial Peptide Expression and Susceptibility to Bacterial Skin Infection B Muehleisen, DD Bikle, C Aguilera, DW Burton, GL Sen, LJ Deftos, RL Gallo	Science Translational Medicine	2012
Protective actions of vitamin D in UVB induced skin cancer DD Bikle	Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology	2012
Rickets Due to Hereditary Abnormalities of Vitamin D Synthesis or Action AA Portale, F Perwad, WL Miller	Pediatric Bone	2012
Pediatric Bone M Bastepe, H Jüppner, RV Thakker	Pediatric Bone	2012
Extraskeletal Effects of Vitamin D H Wolden-Kirk, C Gysemans, A Verstuyf, C Mathieu	Endocrinology and metabolism clinics of North America	2012
Opening of Chloride Channels by 1α,25-Dihydroxyvitamin D3 Contributes to Photoprotection against UVR-Induced Thymine Dimers in Keratinocytes VB Sequeira, MS Rybchyn, C Gordon-Thomson, W Tongkao-on, MT Mizwicki, AW Norman, VE Reeve, GM Halliday, RS Mason	Journal of Investigative Dermatology	2012
Sinonasal epithelial cells synthesize active vitamin D, augmenting host innate immune function: Vitamin D augments sinonasal innate immunity B Sultan, M Ramanathan, J Lee, L May, AP Lane	International Forum of Allergy & Rhinology	2012
1α,25-Dihydroxyvitamin D3 reduces several types of UV-induced DNA damage and contributes to photoprotection EJ Song, C Gordon-Thomson, L Cole, H Stern, GM Halliday, DL Damian, VE Reeve, RS Mason	The Journal of Steroid Biochemistry and Molecular Biology	2012
Expression of the vitamin D-activating enzyme 1α-hydroxylase (CYP27B1) decreases during melanoma progression AA Brożyna, W Jóźwicki, Z Janjetovic, AT Slominski	Human Pathology	2012
Activity of 25-Hydroxylase in Human Gingival Fibroblasts and Periodontal Ligament Cells K Liu, H Meng, J Hou, AT Slominski	PloS one	2012
Vitamin D and the Lung AA Litonjua		2012
Vitamin D metabolism and function in the skin DD Bikle	Molecular and Cellular Endocrinology	2011
Vitamin D metabolism in the kidney: Regulation by phosphorus and fibroblast growth factor 23 F Perwad, AA Portale	Molecular and Cellular Endocrinology	2011
Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles by human CYP27A1 EW Tieu, W Li, J Chen, DM Baldisseri, AT Slominski, RC Tuckey	The Journal of Steroid Biochemistry and Molecular Biology	2011
Expression of vitamin D receptor (VDR) decreases during progression of pigmented skin lesions AA Brożyna, W Jozwicki, Z Janjetovic, AT Slominski	Human Pathology	2011
Vitamin D analogs in the treatment of psoriasis L Trémezaygues, J Reichrath	Dermato-endocrinology	2011
Extrarenal 1α-Hydroxylase M Hewison, JS Adams	Vitamin D	2011
Sunlight Protection by Vitamin D Compounds RS Mason, KM Dixon, VB Sequeira, C Gordon-Thomson	Vitamin D	2011
Vitamin D analogs in the treatment of psoriasis: Where are we standing and where will we be going? L Trémezaygues, J Reichrath	Dermato-endocrinology	2011
20-Hydroxyvitamin D 2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells AT Slominski, TK Kim, Z Janjetovic, RC Tuckey, R Bieniek, J Yue, W Li, J Chen, MN Nguyen, EK Tang, D Miller, TC Chen, M Holick	American journal of physiology. Cell physiology	2011
Nutrition and Skin A Pappas		2011
Vitamin D metabolism B Lehmann, M Meurer	Dermatologic Therapy	2010
Bioactive Foods and Extracts A Teichert, D Bikle	Bioactive Foods and Extracts	2010
Topical treatment with the vitamin D analogue calcipotriol enhances the upregulation of the antimicrobial protein hCAP18/LL-37 during wounding in human skinin vivo JD Heilborn, G Weber, A Grönberg, C Dieterich, M Ståhle	Experimental Dermatology	2010
Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity AT Slominski, Z Janjetovic, BE Fuller, MA Zmijewski, RC Tuckey, MN Nguyen, T Sweatman, W Li, J Zjawiony, D Miller, TC Chen, G Lozanski, MF Holick	PloS one	2010
Vitamin D status in psoriasis patients during different treatments with phototherapy A Osmancevic, K Landin-Wilhelmsen, O Larkö, AL Krogstad	Journal of Photochemistry and Photobiology B Biology	2010
Photoprotection by 1α,25-dihydroxyvitamin D and analogs: Further studies on mechanisms and implications for UV-damage RS Mason, VB Sequeira, KM Dixon, C Gordon-Thomson, K Pobre, A Dilley, MT Mizwicki, AW Norman, D Feldman, GM Halliday, VE Reeve	The Journal of Steroid Biochemistry and Molecular Biology	2010
Metabolism of substrates incorporated into phospholipid vesicles by mouse 25-hydroxyvitamin D3 1α-hydroxylase (CYP27B1) EK Tang, KJ Voo, MN Nguyen, RC Tuckey	The Journal of Steroid Biochemistry and Molecular Biology	2010
Signaling Pathways in Squamous Cancer AB Glick, CV Waes		2010
Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D 3 , Producing 1α,20,23-Trihydroxyvitamin D 3 , Which Has Altered Biological Activity EK Tang, W Li, Z Janjetovic, MN Nguyen, Z Wang, A Slominski, RC Tuckey	Drug Metabolism and Disposition	2010
Zur Bedeutung des Vitamin-D-Stoffwechsels in der humanen Haut: Eine aktuelle Standortbestimmung L Trémezaygues, J Reichrath	Der Hautarzt	2010
TGF-β2is specifically expressed in human dermal papilla cells and modulates hair folliculogenesis K Inoue, N Aoi, Y Yamauchi, T Sato, H Suga, H Eto, H Kato, Y Tabata, K Yoshimura	Journal of Cellular and Molecular Medicine	2009
Vitamin D and immune function: Understanding common pathways DD Bikle	Current Osteoporosis Reports	2009
20,23-dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF-ÎºB activity in human keratinocytes Z Janjetovic, RC Tuckey, MN Nguyen, EM Thorpe, AT Slominski	Journal of Cellular Physiology	2009
Extra Renal Synthesis of 1,25-dihydroxyvitamin D and its Health Implications DD Bikle	Clinical Reviews in Bone and Mineral Metabolism	2009
Role of the vitamin D3pathway in healthy and diseased skin - facts, contradictions and hypotheses B Lehmann	Experimental Dermatology	2009
Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation C Oudshoorn, TJ van der Cammen, ME McMurdo, JP van Leeuwen, EM Colin	British Journal of Nutrition	2009
Seasonal Variation of Maternal Serum Vitamin D in Newfoundland and Labrador S Sloka, J Stokes, E Randell, LA Newhook	Journal of Obstetrics and Gynaecology Canada	2009
20-Hydroxyvitamin D3, a Product of Vitamin D3 Hydroxylation by Cytochrome P450scc, Stimulates Keratinocyte Differentiation B Zbytek, Z Janjetovic, RC Tuckey, MA Zmijewski, TW Sweatman, E Jones, MN Nguyen, AT Slominski	Journal of Investigative Dermatology	2008
Respiratory Epithelial Cells Convert Inactive Vitamin D to Its Active Form: Potential Effects on Host Defense S Hansdottir, MM Monick, SL Hinde, N Lovan, DC Look, GW Hunninghake	Journal of immunology (Baltimore, Md. : 1950)	2008
Contemporary Diagnosis and Treatment of Vitamin D-Related Disorders G Jones, R Horst, G Carter, HL Makin	Journal of Bone and Mineral Research	2007
Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators D Bikle, A Teichert, N Hawker, Z Xie, Y Oda	The Journal of Steroid Biochemistry and Molecular Biology	2007
Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Z Xie, S Chang, Y Oda, DD Bikle	Endocrinology	2006
UVB-induced production of 1,25-dihydroxyvitamin D3 and vitamin D activity in human keratinocytes pretreated with a sterol Δ7-reductase inhibitor K Vantieghem, AM Kissmeyer, PD Haes, R Bouillon, S Segaert	Journal of Cellular Biochemistry	2006
Vitamin D: Its role in cancer prevention and treatment MF Holick	Progress in Biophysics and Molecular Biology	2006
Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy Y Wang, J Zhou, AW Minto, BK Hack, JJ Alexander, M Haas, YC Li, CW Heilig, RJ Quigg	Kidney International	2006
UVB-induced 1,25(OH)2D3 production and vitamin D activity in intestinal CaCo-2 cells and in THP-1 macrophages pretreated with a sterol Δ7-reductase inhibitor K Vantieghem, L Overbergh, G Carmeliet, PD Haes, R Bouillon, S Segaert	Journal of Cellular Biochemistry	2006
Wavelength-Dependent Induction of CYP24A1-mRNA after UVB-Triggered Calcitriol Synthesis in Cultured Human Keratinocytes M Bär, D Domaschke, A Meye, B Lehmann, M Meurer	Journal of Investigative Dermatology	2006
Dermal fibroblasts pretreated with a sterol Δ7-reductase inhibitor produce 25-hydroxyvitamin D3 upon UVB irradiation K Vantieghem, PD Haes, R Bouillon, S Segaert	Journal of Photochemistry and Photobiology B Biology	2006
Prostaglandin E1 Increases in vivo and in vitro calcitriol biosynthesis in rabbits F Velásquez-Forero, P García, JT Triffitt, F Llach	Prostaglandins, Leukotrienes and Essential Fatty Acids	2006
Evidence for auto/paracrine actions of vitamin D in bone: 1α-hydroxylase expression and activity in human bone cells M van Driel, M Koedam, CJ Buurman, M Hewison, H Chiba, AG Uitterlinden, HA Pols, JP van Leeuwen	The FASEB Journal	2006
VITAMIN D IN HEALTH AND DISEASE: Vitamin D for Health and in Chronic Kidney Disease MF Holick	Seminars in Dialysis	2005
Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism B Moosgaard, P Vestergaard, L Heickendorff, F Melsen, P Christiansen, L Mosekilde	Clinical Endocrinology	2005
The Vitamin D3 Pathway in Human Skin and its Role for Regulation of Biological Processes B Lehmann	Photochemistry and Photobiology	2005
Ultraviolet Radiation, Vitamin D and Risk of Prostate Cancer and Other Diseases SJ Moon, AA Fryer, RC Strange	Photochemistry and Photobiology	2005
CYP27B1 null mice with LacZreporter gene display no 25-hydroxyvitamin D3-1alpha-hydroxylase promoter activity in the skin JL Vanhooke, JM Prahl, C Kimmel-Jehan, M Mendelsohn, EW Danielson, KD Healy, HF DeLuca	Proceedings of the National Academy of Sciences	2005
Skin Barrier D Bikle	Skin Barrier	2005
The Vitamin D Epidemic and its Health Consequences MF Holick	The Journal of nutrition	2005
Dermatologie und Venerologie O Braun-Falco, G Plewig, HH Wolff, WH Burgdorf, M Landthaler		2005
Cytochrome P450 PR de Montellano	Cytochrome P450	2005
Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation DD Bikle, Y Oda, Z Xie	The Journal of Steroid Biochemistry and Molecular Biology	2004
Vitamin D regulated keratinocyte differentiation DD Bikle	Journal of Cellular Biochemistry	2004
Vitamin D and skin: new aspects for dermatology B Lehmann, K Querings, J Reichrath	Experimental Dermatology	2004
Rat growth plate chondrocytes express low levels of 25-hydroxy-1α-hydroxylase U Hügel, L Weber, J Reichrath, O Mehls, G Klaus	The Journal of Steroid Biochemistry and Molecular Biology	2004
C-25 hydroxylation of 1α,24(R)-dihydroxyvitamin D3 is catalyzed by 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1): metabolism studies with human keratinocytes and rat recombinant CYP24A1 N Astecker, EA Bobrovnikova, JL Omdahl, L Gennaro, P Vouros, I Schuster, MR Uskokovic, S Ishizuka, G Wang, GS Reddy	Archives of Biochemistry and Biophysics	2004
Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function DD Bikle, S Chang, D Crumrine, H Elalieh, MQ Man, O Dardenne, Z Xie, RS Arnaud, K Feingold, PM Elias	The Journal of Steroid Biochemistry and Molecular Biology	2004
Analysis of the vitamin D system in basal cell carcinomas (BCCs) T Mitschele, B Diesel, M Friedrich, V Meineke, RM Maas, BC Gärtner, J Kamradt, E Meese, W Tilgen, J Reichrath	Laboratory Investigation	2004
Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis MF Holick	The American journal of clinical nutrition	2004
Vitamin D and Skin Cancer DD Bikle	The Journal of nutrition	2004
Nutrition and Bone Health MF Holick, B Dawson-Hughes		2004
Neue Aspekte zur Bedeutung des Vitamin-D 3 -Stoffwechsels in der Haut B Lehmann, K Querings, J Reichrath	Der Hautarzt	2004
Cutaneous Photobiology. The Melanocyte vs. the Sun: Who Will Win the Final Round? AL Kadekaro, RJ Kavanagh, K Wakamatsu, S Ito, MA Pipitone, ZA Abdel-Malek	Pigment Cell Research	2003
Demonstration of UVB-induced synthesis of 1α,25-dihydroxyvitamin D3 (calcitriol) in human skin by microdialysis B Lehmann, W Sauter, P Knuschke, S Dreßler, M Meurer	Archives of Dermatological Research	2003
Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health V Tangpricha, P Koutkia, SM Rieke, TC Chen, AA Perez, MF Holick	The American journal of clinical nutrition	2003
Vitamin D Analogs in Cancer Prevention and Therapy J Reichrath, W Tilgen, M Friedrich		2003
Lack of the Vitamin D Receptor is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth Z Xie, L Komuves, QC Yu, H Elalieh, DC Ng, C Leary, S Chang, D Crumrine, T Yoshizawa, S Kato, DD Bikle	Journal of Investigative Dermatology	2002
Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health MF Holick	Current Opinion in Endocrinology & Diabetes	2002
Clonal Differences in Expression of 25-Hydroxyvitamin D3-1α-hydroxylase, of 25-Hydroxyvitamin D3-24-hydroxylase, and of the Vitamin D Receptor in Human Colon Carcinoma Cells: Effects of Epidermal Growth Factor and 1α,25-Dihydroxyvitamin D3 P Bareis, E Kállay, MG Bischof, G Bises, H Hofer, C Pötzi, T Manhardt, R Bland, HS Cross	Experimental Cell Research	2002
Biologic Effects of Light 2001 MF Holick		2002
Dietary Phosphorus Transcriptionally Regulates 25-Hydroxyvitamin D-1α-Hydroxylase Gene Expression in the Proximal Renal Tubule MY Zhang, X Wang, JT Wang, NA Compagnone, SH Mellon, JL Olson, HS Tenenhouse, WL Miller, AA Portale	Endocrinology	2002
Identification of a Renal Proximal Tubular Cell-Specific Enhancer in the Mouse 25-Hydroxyvitamin D 1α-Hydroxylase Gene T Yoshida, J Yoshino, M Hayashi, T Saruta	Journal of the American Society of Nephrology : JASN	2002
Inhibition of 1,25-Dihydroxyvitamin-D-Induced Keratinocyte Differentiation by Blocking the Expression of Phospholipase C-gamma1 Z Xie, DD Bikle	Journal of Investigative Dermatology	2001
Genetics of vitamin D biosynthesis and its disorders WL Miller, AA Portale	Best Practice & Research Clinical Endocrinology & Metabolism	2001
UVB-Induced Conversion of 7-Dehydrocholesterol to 1alpha,25-Dihydroxyvitamin D3 in an In Vitro Human Skin Equivalent Model B Lehmann, T Genehr, P Knuschke, J Pietzsch, M Meurer	Journal of Investigative Dermatology	2001
Analysis of Basal Regulatory Elements in the 25-Hydroxyvitamin D3 1α-Hydroxylase Gene Promoter HL Brenza, HF DeLuca	Archives of Biochemistry and Biophysics	2001
Skin is an autonomous organ in synthesis, two-step activation and degradation of vitamin D3: CYP27 in epidermis completes the set of essential vitamin D3-hydroxylases M Schuessler, N Astecker, G Herzig, G Vorisek, I Schuster	Steroids	2001
Selective inhibitors of CYP24: mechanistic tools to explore vitamin D metabolism in human keratinocytes I Schuster, H Egger, N Astecker, G Herzig, M Schüssler, G Vorisek	Steroids	2001
Selective inhibition of vitamin D hydroxylases in human keratinocytes11Abbreviations: VD: vitamin D3; 25(OH)D3: 25-hydroxyvitamin D3; 3H-25(OH)D3: [26,27n-3H] 25-hydroxyvitamin D3; 1α,25(OH)2D3: 1α,25-dihydroxyvitamin D3; 1α,25(OH)2-3epi-D3: 1α,25-dihydroxyvitamin-3-epi-D3; 1α,24(R),25(OH)3D3: 1α,24(R),25-trihydroxyvitamin D3, 1α,25(OH)2-24oxo-D3: 1α,25-dihydroxy-24oxo-vitamin D3; 1α,23(S),25(OH)3-24oxo-D3: 1α,23(S),25-trihydroxy-24oxo-vitamin D3; calcitroic acid: 1α-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D3; CYP: cytochrome P450; 1α-hydroxylase: 25-hydroxyvitamin D3-1α-hydroxylase; 24-hydroxylase (CYP24), 1α,25-hydroxyvitamin D3-24-hydroxylase; PHK, primary human keratinocytes; KGM: keratinocyte growth medium; HPLC, high performance liquid chromatography; IC50: half-maximum inhibitor concentration; SD: standard deviation I Schuster, H Egger, D Bikle, G Herzig, GS Reddy, A Stuetz, P Stuetz, G Vorisek	Steroids	2001
UVB-induced Conversion of 7-Dehydrocholesterol to 1α,25-Dihydroxyvitamin D3 (Calcitriol) in the Human Keratinocyte Line HaCaT¶ B Lehmann, P Knuschke, M Meurer	Photochemistry and Photobiology	2000
Vitamin D 1α-Hydroxylase WL Miller, AA Portale	Trends in Endocrinology & Metabolism	2000
Identification of a 25-Hydroxyvitamin D3 1α-Hydroxylase Gene Transcription Product in Cultures of Human Syncytiotrophoblast Cells1 L Díaz, I Sánchez, E Avila, A Halhali, F Vilchis, F Larrea	The Journal of clinical endocrinology and metabolism	2000
Production of 1α,25-Dihydroxy-3-epi-vitamin D3 in two rat osteosarcoma cell lines (UMR 106 and ROS 17/2.8): existence of the C-3 epimerization pathway in ROS 17/2.8 cells in which the C-24 oxidation pathway is not expressed ML Siu-Caldera, H Sekimoto, A Weiskopf, P Vouros, KR Muralidharan, WH Okamura, J Bishop, AW Norman, MR Uskoković, I Schuster, GS Reddy	Bone	1999
GENETIC DISORDERS OF VITAMIN D BIOSYNTHESIS WL Miller, AA Portale	Endocrinology & Metabolism Clinics of North America	1999
1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes AV Ratnam, DD Bikle, JK Cho	Journal of Cellular Physiology	1999
1α,25-Dihydroxy-3-epi-vitamin D3: In vivo metabolite of 1α,25-dihydroxyvitamin D3 in rats H Sekimoto, ML Siu-Caldera, A Weiskopf, P Vouros, KR Muralidharan, WH Okamura, MR Uskokovic, GS Reddy	FEBS Letters	1999
Vitamin D: Non-skeletal actions and effects on growth H Lal, R Pandey, SK Aggarwal	Nutrition Research	1999
Human keratinocyte line HaCaT metabolizes 1α-hydroxyvitamin D3 and vitamin D3 to 1α,25-dihydroxyvitamin D3 (calcitriol) B Lehmann, J Pietzsch, A Kämpf, M Meurer	Journal of Dermatological Science	1998
Current Understanding of the Molecular Actions of Vitamin D G Jones, SA Strugnell, HE DeLUCA	Physiological reviews	1998
Osteoporosis DL Glaser, FS Kaplan	Spine	1997
1alpha,25-Dihydroxyvitamin D3 and a Variety of its Natural Metabolites Transcriptionally Repress Nuclear-Factor-kappaB-Mediated Interleukin-8 Gene Expression H Harant, PJ Andrew, GS Reddy, E Foglar, IJ Lindley	European Journal of Biochemistry	1997
HaCaT Cell Line as a Model System for Vitamin D3 Metabolism in Human Skin B Lehmann	Journal of Investigative Dermatology	1997
Advances in Molecular and Cell Biology KJ Clemetson	Advances in Molecular and Cell Biology	1997
Vitamin D metabolism in human colon adenocarcinoma-derived Caco-2 cells: Expression of 25-hydroxyvitamin D3-1α-hydroxylase activity and regulation of sidechain metabolism HS Cross, M Peterlik, GS Reddy, I Schuster	The Journal of Steroid Biochemistry and Molecular Biology	1997
1,25-Dihydroxyvitamin D3 Regulates Estrogen Metabolism in Cultured Keratinocytes* SV Hughes, E Robinson, R Bland, HM Lewis, PM Stewart, M Hewison	Endocrinology	1997
Inhibitory effect of 1α,25-dihydroxyvitamin D3 on mast cell proliferation and A23187-induced histamine release, also accompanied by a decreased c-kit receptor N Toyota, H Sakai, H Takahashi, Y Hashimoto, H Iizuka	Archives of Dermatological Research	1996
Immunohistochemical Detection of 1,25-dihydroxyvitamin D3 Receptors (VDR) in Human Skin J Reichrath, ED Collins, S Epple, A Kerber, AW Norman, FA Bahmer	Pathology - Research and Practice	1996
Effect of UVB phototherapy and oral calcitriol (1,25-dihydroxyvitamin D3) on vitamin D photosynthesis in patients with psoriasis JH Prystowsky, PJ Muzio, S Sevran, TL Clemens	Journal of the American Academy of Dermatology	1996
Anti-proliferative activity and target cell catabolism of the vitamin D analog 1α,24(S)-(OH)2D2 in normal and immortalized human epidermal cells G Jones, V Byford, HL Makin, R Kremer, RH Rice, LA deGraffenried, JC Knutson, CW Bishop	Biochemical Pharmacology	1996
Antiproliferative effects of the biologically active metabolite of vitamin D3 (1,25 [OH]2 D3) on head and neck squamous cell carcinoma cell lines J Kornfehl, M Formanek, A Temmel, B Knerer, M Willheim	European Archives of Oto-Rhino-Laryngology	1996
22-Oxa Calcitriol Is a Less Potent Regulator of Keratinocyte Proliferation and Differentiation Due to Decreased Cellular Uptake and Enhanced Catabolism DD Bikle, J Abe-Hashimoto, MJ Su, S Felt, DF Gibson, S Pillai	Journal of Investigative Dermatology	1995
Production of 1,25 Dihydroxyvitamin D3 by Perfused Pig Skin DD Bikle, BP Halloran, JE Riviere	Journal of Investigative Dermatology	1994
Synthesis of and response to 1,25 dihydroxycholecalciferol by subpopulations of murine epidermal keratinocytes: Existence of a paracrine system for 1,25 dihydroxycholecalciferol M Rizk-Rabin, R Zineb, B Zhor, G Michele, P Jana	Journal of Cellular Physiology	1994
1,25-Dihydroxyvitamin D3 potentiates the keratinocyte response to calcium MJ Su, DD Bikle, ML Mancianti, S Pillai	The Journal of biological chemistry	1994
Intracellular free calcium and growth changes in single human keratinocytes in response to vitamin D and five 20-epi-analogues KT Jones, GR Sharpe	Archives of Dermatological Research	1994
Regulation of Keratinocyte Growth, Differentiation, and Vitamin D Metabolism by Analogs of 1,25-Dihydroxyvitamin D DD Bikle, E Gee, S Pillai	Journal of Investigative Dermatology	1993
Physiology and Pharmacology of Bone GR Mundy, TJ Martin		1993
Editorial S Wolf	Integrative Physiological and Behavioral Science	1992
Vitamin D analogues in the treatment of psoriasis K Kragballe	Journal of Cellular Biochemistry	1992
Parathyroid hormone stimulates protein kinase C but not adenylate cyclase in mouse epidermal keratinocytes JF Whitfield, BR Chakravarthy, JP Durkin, RJ Isaacs, H Jouishomme, M Sikorska, RE Williams, RH Rixon	Journal of Cellular Physiology	1992
1,25-dihydroxy-vitamin-D3 enhances antiproliferative effect and transcription of TGF-?1 on human keratinocytes in culture HJ Kim, N Abdelkader, M Katz, JA McLane	Journal of Cellular Physiology	1992
Vitamin D and Psoriasis KE Lowe, AW Norman	Nutrition Reviews	1992
Characterization and regulation of the vitamin D hydroxylases HJ Armbrecht, K Okuda, N Wongsurawat, RK Nemani, ML Chen, MA Boltz	The Journal of Steroid Biochemistry and Molecular Biology	1992
Analysis of PTHRP binding and signal transduction mechanisms in benign and malignant squamous cells JJ Orloff, MB Ganz, AE Ribaudo, WJ Burtis, M Reiss, LM Milstone, AF Stewart	American journal of physiology. Endocrinology and metabolism	1992
Squamous Carcinoma Cell Lines Produce 1,25 Dihydroxyvitamin D, but Fail to Respond to Its Prodifferentiating Effect DD Bikle, S Pillai, E Gee	Journal of Investigative Dermatology	1991
1α,25(OH)2 vitamin D3 increases intracellular calcium in human keratinocytes B Bittiner, SS Bleehen, S Macneil	British Journal of Dermatology	1991
Involvement of endogenously produced 1,25-dihydroxyvitamin D-3 in the growth and differentiation of human keratinocytes K Matsumoto, Y Azuma, M Kiyoki, H Okumura, K Hashimoto, K Yoshikawa	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	1991
Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds E Arinç, JB Schenkman, E Hodgson		1991
Melanoma Research: Genetics, Growth Factors, Metastases, and Antigens L Nathanson		1991
The Nature and Biological Effects of Factors Responsible for Proliferation and Differentiation of Melanocytes ZA Abdel-Malek, VB Swope, JJ Nordlund	Pigment Cell Research	1990
Inverse relation between severity of psoriasis and serum 1,25-dihydroxyvitamin D level S Morimoto, K Yoshikawa, K Fukuo, T Shiraishi, E Koh, S Imanaka, S Kitano, T Ogihara	Journal of Dermatological Science	1990
Dermatology MH Rustin	Postgraduate medical journal	1990
25-Hydroxyvitamin D3-1 alpha-hydroxylase in porcine hepatic tissue: subcellular localization to both mitochondria and microsomes BW Hollis	Proceedings of the National Academy of Sciences	1990
Clinical and Laboratory Evaluation of Renal Stone Patients DM Wilson	Endocrinology and metabolism clinics of North America	1990
Vitamin D A Portale, Β Halloran, E Lonergan, R Morris	Vitamin D	1988
Extra-renal production of calcitriol in chronic renal failure A Dusso, S Lopez-Hilker, N Rapp, E Slatopolsky	Kidney International	1988
Vitamin D Metabolite Production and Function in Keratinocytes DD Bikle, S Pillai	Annals of the New York Academy of Sciences	1988
Characterization of a parathyroid Hormonelike Peptide Secreted by Human Keratinocytes KL Insogna, AF Stwart, K Ikeda, M Centrella, LM Milsone	Annals of the New York Academy of Sciences	1988
Human Melanocytes as a Target Tissue for Hormones: In Vitro Studies with 1alpha-25, dihydroxyvitamin D3, alpha-melanocyte Stimulating Hormone, and Beta-estradiol M Ranson, S Posen, RS Mason	Journal of Investigative Dermatology	1988
Human Melanoma Cells: Functional Modulation by Calciotropic Hormones RS Mason, AM Pryke, M Ranson, HE Thomas, S Posen	Journal of Investigative Dermatology	1988
Hormonal effects of vitamin D3 on epidermal melanocytes ZA Abdel-Malek, R Ross, L Trinkle, V Swope, JW Pike, JJ Nordlund	Journal of Cellular Physiology	1988
Metabolic Activation of Carcinogens by Keratinocytes DR Bickers	Annals of the New York Academy of Sciences	1988
Actions of 1?,25-Dihydroxyvitamin D3on Normal, Psoriatic, and Promoted Epiderma1 Keratinocytes T Kuroki, S Morimoto, T Suda	Annals of the New York Academy of Sciences	1988
Endocrine-skin interactions KR Feingold, PM Elias	Journal of the American Academy of Dermatology	1988
Endocrine Factors as Effectors of Integumental Pigmentation ZA Abdel-Malek	Dermatologic Clinics	1988
1,25-Dihydroxyvitamin D production and receptor binding in human keratinocytes varies with differentiation S Pillai, DD Bikle, PM Elias	The Journal of biological chemistry	1988
Advances in Lipid Research AM Scanu	Advances in Lipid Research	1965

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