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Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity.
K Takahashi, … , P E Newburger, H J Cohen
K Takahashi, … , P E Newburger, H J Cohen
Published April 1, 1986
Citation Information: J Clin Invest. 1986;77(4):1402-1404. https://doi.org/10.1172/JCI112449.
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Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity.

Abstract

Glutathione peroxidase (GSHPx) activity is an indicator of selenium status in selenium-deficient individuals. Utilizing polyclonal monospecific antibodies to purified erythrocyte GSHPx, we were able to determine the relationship between enzymatic activity and protein content. In erythrocytes from a selenium-deficient individual who was treated with selenium, and in HL-60 cells grown in the absence of selenium and then returned to selenium-containing medium, there was a direct relationship between enzymatic activity and protein content. Thus, selenium deficiency results not only in a decrease of GSHPx activity, but also in a decrease of GSHPx protein.

Authors

K Takahashi, P E Newburger, H J Cohen

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Citations to this article (74)

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