Advertisement
Research Article Free access | 10.1172/JCI112449
Find articles by Takahashi, K. in: JCI | PubMed | Google Scholar
Find articles by Newburger, P. in: JCI | PubMed | Google Scholar
Find articles by Cohen, H. in: JCI | PubMed | Google Scholar
Published April 1, 1986 - More info
Glutathione peroxidase (GSHPx) activity is an indicator of selenium status in selenium-deficient individuals. Utilizing polyclonal monospecific antibodies to purified erythrocyte GSHPx, we were able to determine the relationship between enzymatic activity and protein content. In erythrocytes from a selenium-deficient individual who was treated with selenium, and in HL-60 cells grown in the absence of selenium and then returned to selenium-containing medium, there was a direct relationship between enzymatic activity and protein content. Thus, selenium deficiency results not only in a decrease of GSHPx activity, but also in a decrease of GSHPx protein.
Click on an image below to see the page. View PDF of the complete article