Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.
A A Rossini, … , M C Appel, E S Handler
A A Rossini, … , M C Appel, E S Handler
Published April 1, 1986
Citation Information: J Clin Invest. 1986;77(4):1399-1401. https://doi.org/10.1172/JCI112448.
View: Text | PDF
Research Article

Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.

Abstract

We report that transfusions of RT1u Wistar-Furth (WF) spleen cells prevented spontaneous diabetes in the RT1u BB/W rat while RT1b Buffalo rat spleen cells did not. In addition, donor origin WF T lymphocytes were detected in nondiabetic-susceptible BB/W recipients 5 mo after transfusion. Survival of donor-origin lymphocytes may provide the cellular mechanism by which major histocompatibility complex-compatible WF spleen cell transfusions prevent BB rat diabetes.

Authors

A A Rossini, J P Mordes, D L Greiner, K Nakano, M C Appel, E S Handler

×

Full Text PDF | Download (569.94 KB)