Citations to this article
Abstract
Bone marrow cells from a patient with Ph' positive chronic myelogenous leukemia in chronic phase were cultured for multilineage hematopoietic colonies (CFU-GEMMT), erythroid bursts, and granulocytic colonies. With CFU-GEMMT colonies, T lymphocytes were identified by reaction with monoclonal antibodies Leu-5 and OKT-3; B cells were identified by reaction with B1. All CFU-GEMMT colonies examined contained the Ph' chromosome. Recloned secondary colonies of T cells reacted with Leu-5 and OKT-3 and were Ph' positive. This demonstrates that Ph' positive T lymphocytes were generated from the pluripotential stem cell of this patient. The presence of B cells in the mixed colonies indicates that these may also be derived from the neoplastic clone.
Authors
A A Fauser, L Kanz, K J Bross, G W Löhr
Total citations by year
Citations to this article in year 1989 (4)
| Title and authors | Publication | Year |
|---|---|---|
|
Laboratory and clinical applications of monoclonal antibodies for leukemias and non-Hodkin's lymphoma
KA Foon |
Current Problems in Cancer | 1989 |
|
Rapid decline of clonogenic hemopoietic progenitors in semisolid cultures of bone marrow samples derived from patients with chronic myeloid leukemia
U Wandl, HA Messner |
The International Journal of Cell Cloning | 1989 |
|
Characterization of lympho-myeloid-erythroid-megakaryocytic stem cells in peripheral blood of hairy cell leukemia patients
R Michalevicz, S Baron, S Brill, E Sahar |
Leukemia Research | 1989 |
|
Ph-negative T cells in a patient with chronic myelogenous leukemia for twenty-eight years
PC Nowell, JB Finan, JS Moore, L Jackson, A Weiss |
Leukemia Research | 1989 |
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