Go to
JCI Insight
Citations to this article
R J Falk, … , H Gewurz, A F Michael
Published August 1, 1983
Citation Information: J Clin Invest. 1983;72(2):560-573. https://doi.org/10.1172/JCI111004.
Citation Information: J Clin Invest. 1983;72(2):560-573. https://doi.org/10.1172/JCI111004.
Abstract
A monoclonal antibody to a neoantigen of the C9 portion of the membrane attack complex (MAC) of human complement has been developed and characterized. The distribution of this neoantigen was assessed by indirect immunofluorescence microscopy in nephritic and nonnephritic renal diseases. The antibody (Poly C9-MA) reacted on enzyme-linked immunosorbent assay (ELISA) with a determinant in complement-activated serum that was undetectable in normal human serum (NHS). Zymosan particles incubated in NHS had positive immunofluorescent staining with Poly C9-MA; however, binding of Poly C9-MA was not observed with zymosan particles incubated in sera deficient in individual complement components C3, C5, C6, C7, C8, or C9. Reconstitution of C9-deficient sera with purified C9 restored the fluorescence with Poly C9-MA. Poly C9-MA reacted positively by ELISA in a dose-dependent manner with purified MC5b-9 solubilized from membranes of antibody-coated sheep erythrocytes treated with NHS but not with intermediate complement complexes. Poly C9-MA also reacted in a dose-dependent manner on ELISA and in a radioimmunoassay with polymerized C9 (37 degrees C, 64 h) (poly C9) but not with monomeric C9. Increasing amounts of either unlabeled poly C9 or purified MC5b-9 inhibited the 125I-poly C9 RIA in an identical manner. These studies demonstrate that Poly C9-MA recognizes a neoantigen of C9 common to both the MAC and to poly C9. By immunofluorescence, Poly C9-MA reacted minimally with normal kidney tissue in juxtaglomerular loci, the mesangial stalk, and vessel walls. Poly C9-MA stained kidney tissue from patients with glomerulonephritis in a pattern similar to that seen with polyclonal anti-human C3. In tissue from patients with nonnephritic renal disease--diabetes, hypertension, and obstructive uropathy--Poly C9-MA was strongly reactive in the mesangial stalk and juxtaglomerular regions, tubular basement membranes, and vascular walls. Poly C9-MA binding was especially prominent in areas of advanced tissue injury. Poly C9-MA frequently stained loci where C3 was either minimally present or absent. These studies provide strong evidence for complement activation not only in nephritic but also in nonnephritic renal diseases.
Authors
R J Falk, A P Dalmasso, Y Kim, C H Tsai, J I Scheinman, H Gewurz, A F Michael
Total citations by year
Citation information
Citations to this article (193)
| Title and authors | Publication | Year |
|---|---|---|
|
Complement Cascade Proteins Correlate with Fibrosis and Inflammation in Early-Stage Type 1 Diabetic Kidney Disease in the Ins2Akita Mouse Model
Tserga A, Saulnier-Blache JS, Palamaris K, Pouloudi D, Gakiopoulou H, Zoidakis J, Schanstra JP, Vlahou A, Makridakis M |
International journal of molecular sciences | 2024 |
|
Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys
JJ Koopman, MF van Essen, HG Rennke, AP de Vries, C van Kooten |
Frontiers in immunology | 2021 |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
Renal Fibrosis: Mechanisms and Therapies
BC Liu, HY Lan, LL Lv |
2019 | |
|
The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy
DV Rizk, N Maillard, BA Julian, B Knoppova, TJ Green, J Novak, RJ Wyatt |
Frontiers in immunology | 2019 |
|
Glomerular membrane attack complex is not a reliable marker of ongoing C5 activation in lupus nephritis
HR Wilson, NR Medjeral-Thomas, AC Gilmore, P Trivedi, K Seyb, R Farzaneh-Far, I Gunnarsson, A Zickert, TD Cairns, L Lightstone, HT Cook, MC Pickering |
Kidney International | 2019 |
|
Glomerular C4d deposition can precede the development of focal segmental glomerulosclerosis
NA van de Lest, M Zandbergen, R Wolterbeek, R Kreutz, LA Trouw, EM Dorresteijn, JA Bruijn, IM Bajema, M Scharpfenecker, JS Chua |
Kidney International | 2019 |
|
Complement Activation in Patients With Diabetic Nephropathy
P Bus, JS Chua, CQ Klessens, M Zandbergen, R Wolterbeek, C van Kooten, LA Trouw, JA Bruijn, HJ Baelde |
Kidney International Reports | 2018 |
|
Complement activation in patients with diabetic nephropathy
XQ Li, DY Chang, M Chen, MH Zhao |
Diabetes & Metabolism | 2018 |
|
The role of the complement system in diabetic nephropathy
A Flyvbjerg |
Nature Reviews Nephrology | 2017 |
|
C5b-9 does not mediate tubulointerstitial injury in experimental acute glomerular disease characterized by selective proteinuria
GK Rangan |
World Journal of Nephrology | 2016 |
|
Urinary candidate biomarker discovery in a rat unilateral ureteral obstruction model
Y Yuan, F Zhang, J Wu, C Shao, Y Gao |
Scientific Reports | 2015 |
|
Role of Complement and Complement Regulatory Proteins in the Complications of Diabetes
P Ghosh, R Sahoo, A Vaidya, M Chorev, JA Halperin |
Endocrine reviews | 2015 |
|
Pediatric Nephrology
ED Avner, WE Harmon, P Niaudet, N Yoshikawa, F Emma, S Goldstein |
Pediatric Nephrology | 2015 |
|
Inflammatory Pathways in Diabetes
M Pugia |
2015 | |
|
New insights into the reaction of Schistosoma mansoni cercaria to the human complement system
AA Da’dara, G Krautz-Peterson |
Parasitology Research | 2014 |
|
Mast Cells are Important Modifiers of Autoimmune Disease: With so Much Evidence, Why is There Still Controversy?
MA Brown, JK Hatfield |
Frontiers in immunology | 2012 |
|
On the intersections of basic and applied research in xenotransplantation*: Basic and applied research in xenotransplantation
AP Dalmasso |
Xenotransplantation | 2012 |
|
Gene expression differences in skin fibroblasts in identical twins discordant for type 1 diabetes
ML Caramori, Y Kim, JH Moore, SS Rich, JC Mychaleckyj, N Kikyo, M Mauer |
Diabetes | 2012 |
|
Complement activation by (auto-) antibodies
NA Daha, NK Banda, A Roos, FJ Beurskens, JM Bakker, MR Daha, LA Trouw |
Molecular Immunology | 2011 |
|
Advances in assay of complement function and activation
M Harboe, EB Thorgersen, TE Mollnes |
Advanced Drug Delivery Reviews | 2011 |
|
Henry's Clinical Diagnosis and Management by Laboratory Methods
JL Miller, AK Rao |
Henry's Clinical Diagnosis and Management by Laboratory Methods | 2011 |
|
Fetal and Neonatal Physiology
LH Johnson, VK Bhutani |
Fetal and Neonatal Physiology | 2011 |
|
The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice
RD Lewis, CL Jackson, BP Morgan, TR Hughes |
Molecular Immunology | 2010 |
|
IL-4 induces protection of vascular endothelial cells against killing by complement and melittin through lipid biosynthesis
SM Black, ME Schott, BH Batdorf, BA Benson, MS Rutherford, BK Levay-Young, AP Dalmasso |
European Journal of Immunology | 2010 |
|
Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice
Kirsten L. Rose Danielle Paixao-Cavalcante Jennifer Fish Anthony P. Manderson Talat Malik Anne E. Bygrave Tao Lin Steven H. Sacks Mark J. Walport H. Terence Cook Marina Botto Matthew C. Pickering |
Journal of Clinical Investigation | 2008 |
|
C4d Immunohistochemistry in glomerulonephritis with different antibodies
T Suzuki, S Horita, K Kadoya, K Mitsuiki, K Aita, A Harada, K Nitta, M Nagata |
Clinical and Experimental Nephrology | 2007 |
|
Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice
MC Pickering, J Warren, KL Rose, F Carlucci, Y Wang, MJ Walport, HT Cook, M Botto |
Proceedings of the National Academy of Sciences | 2006 |
|
C5b-9 does not mediate chronic tubulointerstitial disease in the absence of proteinuria
GK Rangan, JW Pippin, JD Coombes, WG Couser |
Kidney International | 2005 |
|
IL-4 and IL-13 Induce Protection of Porcine Endothelial Cells from Killing by Human Complement and from Apoptosis through Activation of a Phosphatidylinositide 3-Kinase/Akt Pathway
JF Grehan, BK Levay-Young, JL Fogelson, V François-Bongarçon, BA Benson, AP Dalmasso |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
|
Effects of complement factor D deficiency on the renal disease of MRL/lpr mice
MK Elliott, T Jarmi, P Ruiz, Y Xu, VM Holers, GS Gilkeson |
Kidney International | 2004 |
|
Inhibition of terminal complement: a novel therapeutic approach for the treatment of systemic lupus erythematosus
RP Rother, CF Mojcik, EW McCroskery |
Lupus | 2004 |
|
Complement and the Kidney
RJ Quigg |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
|
End-organ susceptibility as a determinant of renal disease in hypertension
L Raij |
Kidney International | 2003 |
|
Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice
L Bao, M Haas, SA Boackle, DM Kraus, PN Cunningham, P Park, JJ Alexander, RK Anderson, K Culhane, VM Holers, RJ Quigg |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
|
A soluble chimeric inhibitor of C3 and C5 convertases, complement activation blocker-2, prolongs graft survival in pig-to-rhesus monkey heart transplantation
CT Salerno, DM Kulick, CG Yeh, M Guzman-Paz, PJ Higgins, BA Benson, SJ Park, SJ Shumway, RM Bolman, AP Dalmasso |
Xenotransplantation | 2002 |
|
The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants
CL Lau, WC Daggett, MF Yeatman, P Chai, SS Lin, AJ Lodge, EP Chen, LE Diamond, GW Byrne, JS Logan, W Parker, JL Platt, RD Davis |
The Journal of Thoracic and Cardiovascular Surgery | 2000 |
|
Transgenic swine lungs expressing human cd59 are protected from injury in a pig-to-human model of xenotransplantation
DM Kulick, CT Salerno, AP Dalmasso, SJ Park, MG Paz, WL Fodor, RM Bolman |
The Journal of Thoracic and Cardiovascular Surgery | 2000 |
|
Mechanisms of Action of Intravenous Immunoglobulin (IVIG)
MD Kazatchkine, B Bellon, SV Kaveri |
Multiple sclerosis (Houndmills, Basingstoke, England) | 2000 |
|
The Terminal Sequence of Complement Plays an Essential Role in Antibody-Mediated Renal Cell Apoptosis
T Sato, MG DIXHOORN, FA Prins, A Mooney, N Verhagen, Y Muizert, J SAVILL, LA Es, MR Daha |
Journal of the American Society of Nephrology : JASN | 1999 |
|
The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants
SS Lin, BC Weidner, GW Byrne, LE Diamond, JH Lawson, CW Hoopes, LJ Daniels, CW Daggett, W Parker, RC Harland, RD Davis, RR Bollinger, JS Logan, JL Platt |
Journal of Clinical Investigation | 1998 |
|
The Human Complement System in Health and Disease
J Ahearn, A Rosengard |
The Human Complement System in Health and Disease | 1998 |
|
Encyclopedia of Immunology
RL Riley |
Encyclopedia of Immunology | 1998 |
|
IgA Nephropathy—Human Disease and Animal Model
Y Endo |
Renal Failure | 1997 |
|
Detection of renal allograft rejection by complement components C5A and TCC in plasma and urine
TF Muller, M Kraus, C Neumann, H Lange |
Journal of Laboratory and Clinical Medicine | 1997 |
|
TRANSGENIC PIGS EXPRESSING HUMAN CD59 AND DECAY-ACCELERATING FACTOR PRODUCE AN INTRINSIC BARRIER TO COMPLEMENT-MEDIATED DAMAGE1:
GW Byrne, KR McCurry, MJ Martin, SM McClellan, JL Platt, JS Logan |
Transplantation | 1997 |
|
Role of the complement membrane attack complex (C5b-9) in mediating experimental mesangioproliferative glomerulonephritis
J Brandt, J Pippin, M Schulze, GM Hänsch, CE Alpers, RJ Johnson, K Gordon, WG Couser |
Kidney International | 1996 |
|
Transfected CD59 protects mesangial cells from injury induced by antibody and complement
M Nangaku, RL Meek, J Pippin, KL Gordon, BP Morgan, RJ Johnson, WG Couser |
Kidney International | 1996 |
|
Human carcinomas variably express the complement inhibitory proteins CD46 (membrane cofactor protein), CD55 (decay-accelerating factor), and CD59 (protectin)
GA Niehans, DL Cherwitz, NA Staley, DJ Knapp, AP Dalmasso |
The American Journal of Pathology | 1996 |
|
SELECTIVE IgM DEPLETION PROLONGS ORGAN SURVIVAL IN AN EX VIVO MODEL OF PIG-TO-HUMAN XENOTRANSPLANTATION1,2
TJ Kroshus, RM Bolman, AP Dalmasso |
Transplantation | 1996 |
|
Biomembranes: A Multi-Volume Treatise
KJ Clemetson |
Biomembranes: A Multi-Volume Treatise | 1996 |
|
EXPRESSION OF HUMAN CD59 IN TRANSGENIC PIG ORGANS ENHANCES ORGAN SURVIVAL IN AN EX VIVO XENOGENEIC PERFUSION MODEL1,2:
TJ Kroshus, RM Bolman, AP Dalmasso, SA Rollins, ER Guilmette, BL Williams, SP Squinto, WL Fodor |
Transplantation | 1996 |
|
CHARACTERIZATION OF TRANSGENIC PIGS EXPRESSING FUNCTIONALLY ACTIVE HUMAN CD59 ON CARDIAC ENDOTHELIUM:
LE Diamond, KR McCurry, MJ Martin, SB McClellan, ER Oldham, JL Platt, JS Logan |
Transplantation | 1996 |
|
Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation
JC Magee, BH Collins, RC Harland, BJ Lindman, RR Bollinger, MM Frank, JL Platt |
Journal of Clinical Investigation | 1995 |
|
Role of complement in renal tubular damage
T Khan, R Sinniah |
Histopathology | 1995 |
|
Urinary C5b-9 excretion and clinical course in idiopathic human membranous nephropathy
SP Kon, B Coupes, CD Short, LR Solomon, MJ Raftery, NP Mallick, PE Brenchley |
Kidney International | 1995 |
|
Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury
KR McCurry, DL Kooyman, CG Alvarado, AH Cotterell, MJ Martin, JS Logan, JL Platt |
Nature Medicine | 1995 |
|
Pathogenic significance of interleukin-6 in a patient with antiglomerular basement membrane antibody-induced glomerulonephritis with multinucleated giant cells
Y Ito, A Fukatsu, M Baba, M Mizuno, S Ichida, Y Sado, S Matsuo |
American Journal of Kidney Diseases | 1995 |
|
Human CD59 expressed in transgenic mouse hearts inhibits the activation of complement
LE Diamond, KR McCurry, ER Oldham, M Tone, H Waldmann, JL Platt, JS Logan |
Transplant Immunology | 1995 |
|
In Vivo Transfer of GPI-Linked Complement Restriction Factors from Erythrocytes to the Endothelium
DL Kooyman, GW Byrne, S McClellan, D Nielsen, M Tone, H Waldmann, TM Coffman, KR McCurry, JL Platt, JS Logan |
Science | 1995 |
|
Proteinuria—A direct cause of renal morbidity?
JD Williams, GA Coles |
Kidney International | 1994 |
|
Expression of clusterin in human renal diseases
J Dvergsten, JC Manivel, R Correa-Rotter, ME Rosenberg |
Kidney International | 1994 |
|
Advances in Pharmacology
B Drenger, Y Ginosar, Y Gozal |
Advances in Pharmacology | 1994 |
|
Immunohistochemical demonstration of membrane cofactor protein (MCP) of complement in normal and diseased kidney tissues
M Endoh, M Yamashina, H Ohi, K Funahashi, T Ikuno, T Yasugi, JP Atkinson, H Okada |
Clinical & Experimental Immunology | 1993 |
|
Activators and Inhibitors of Complement
RB Sim |
1993 | |
|
Immunohistochemical localization of C3d fragment of complement and S-protein (vitronectin) in normal and diseased human kidneys: association with the C5b-9 complex and vitronectin receptor
M Okada, K Yoshioka, T Takemura, N Akano, N Aya, K Murakami, S Maki |
Virchows Archiv A Pathological Anatomy and Histopathology | 1993 |
|
Immunohistochemical demonstration of membrane cofactor protein (MCP) of complement in normal and diseased kidney tissues.
Endoh M, Yamashina M, Ohi H, Funahashi K, Ikuno T, Yasugi T, Atkinson JP, Okada H |
Clinical & Experimental Immunology | 1993 |
|
Distinct sites of production and deposition of the putative cell death marker clusterin in the human thymus
LE French, AP Sappino, J Tschopp, JA Schifferli |
Journal of Clinical Investigation | 1992 |
|
Tubulointerstitial nephritis
CL Jones, AA Eddy |
Pediatric Nephrology | 1992 |
|
IgA nephropathy in patients with congenital C9 deficiency
K Yoshioka, T Takemura, N Akano, M Okada, K Yagi, S Maki, S Inai, H Akita, Y Koitabashi, Y Takekoshi |
Kidney International | 1992 |
|
Clusterin in renal tissue: preferential localization with the terminal complement complex and immunoglobulin deposits in glomeruli
LE French, J Tschopp, JA Schifferli |
Clinical & Experimental Immunology | 1992 |
|
Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients
AP Dalmasso, GM Vercellotti, RJ Fischel, RM Bolman, FH Bach, JL Platt |
The American Journal of Pathology | 1992 |
|
Persistent complement activation on tumor cells in breast cancer
F Niculescu, HG Rus, M Retegan, R Vlaicu |
The American Journal of Pathology | 1992 |
|
Tubulointerstitial Changes as a Major Determinant in the Progression of Renal Damage
KA Nath |
American Journal of Kidney Diseases | 1992 |
|
The Complement System
A Agostoni, M Cicardi, M Gardinali, L Bergamaschini |
International journal of immunopathology and pharmacology | 1992 |
|
Idiopathic membranoproliferative glomerulonephritis in childhood
CD West |
Pediatric Nephrology | 1992 |
|
Clusterin in renal tissue: preferential localization with the terminal complement complex and immunoglobulin deposits in glomeruli.
French LE, Tschopp J, Schifferli JA |
Clinical & Experimental Immunology | 1992 |
|
Localization of 20-kD homologous restriction factor (HRF20) in diseased human glomeruli. An immunofluorescence study
H Tamai, S Matsuo, A Fukatsu, K Nishikawa, N Sakamoto, K Yoshioka, N Okada, H Okada |
Clinical & Experimental Immunology | 1991 |
|
Differential expression of basement membrane collagen in membranous nephropathy
Y Kim, R Butkowski, B Burke, MM Kleppel, J Crosson, A Katz, AF Michael |
The American Journal of Pathology | 1991 |
|
Blood dendritic cells carry terminal complement complexes on their cell surface as detected by newly developed neoepitope-specific monoclonal antibodies
R Würzner, H Xu, A Franzke, M Schulze, JH Peters, O Götze |
Immunology | 1991 |
|
Human Umbilical Vein Endothelial Cells Synthesize Functional C3, C5, C6, C8 and C9 In Vitro
E Johnson, G Hetland |
Scandinavian Journal of Immunology | 1991 |
|
Eosinophilia myalgia syndrome: I. Immunocytochemical evidence for a T-cell-mediated immune effector response
AM Emslie-Smith, AG Engel, J Duffy, CA Bowles |
Annals of Neurology | 1991 |
|
Nephrology
M Hatano |
Nephrology | 1991 |
|
Acute interstitial nephritis and uveitis syndrome: activated immune cell infiltration in the kidney
K Yoshioka, T Takemura, M Kanasaki, N Akano, S Maki |
Pediatric Nephrology | 1991 |
|
Tubulo-Interstitial Nephropathies
A Amerio, P Coratelli, SG Massry |
1991 | |
|
Localization of 20-kD homologous restriction factor (HRF20) in diseased human glomeruli. An immunofluorescence study.
Tamai H, Matsuo S, Fukatsu A, Nishikawa K, Sakamoto N, Yoshioka K, Okada N, Okada H |
Clinical & Experimental Immunology | 1991 |
|
Immunoregulatory factors in the pathogenesis of IgA nephropathy
SN Emancipator |
Kidney International | 1990 |
|
The role of mesangial cells in glomerular pathology
NJ Hawkins, D Wakefield, JA Charlesworth |
Pathology | 1990 |
|
Membrane attack complex of complement in Henoch-Sch�nlein purpura skin and nephritis
S Kawana, GH Shen, Y Kobayashi, S Nishiyama |
Archives of Dermatological Research | 1990 |
|
Technical improvements in the immunoperoxidase study of renal biopsy specimens
AJ Howie, J Gregory, RA Thompson, MA Adkins, AJ Niblett |
Journal of clinical pathology | 1990 |
|
International Yearbook of Nephrology 1991
VE Andreucci, LG Fine |
1990 | |
|
Classical pathway of complement activation in normal and diseased human glomeruli
J Zwirner, E Felber, V Herzog, G Riethmüller, HE Feucht |
Kidney International | 1989 |
|
Study of the immunopathogenesis of tubulointerstitial nephritis using model systems
CB Wilson |
Kidney International | 1989 |
|
Renal injury in DOCA-salt hypertensive C5-sufficient and C5-deficient mice
L Raij, AP Dalmasso, NA Staley, AJ Fish |
Kidney International | 1989 |
|
Deposition of the Membrane Attack Complex of Complement in Pemphigus Vulgaris and Pemphigus Foliaceus Skin
S Kawana, WD Geoghegan, RE Jordon, S Nishiyanu |
Journal of Investigative Dermatology | 1989 |
|
Complement-Mediated Endothelial Cell Damage in Immune Complex Vasculitis of the Skin: Ultrastructural Localization of the Membrane Attack Complex
BW Boom, M Mommaas, MR Daha, BJ Vermeer |
Journal of Investigative Dermatology | 1989 |
|
Depletion of C6 prevents development of proteinuria in experimental membranous nephropathy in rats
PJ Baker, RF Ochi, M Schulze, RJ Johnson, C Campbell, WG Couser |
The American Journal of Pathology | 1989 |
|
Relative contributions of chemo-attractant and terminal components of complement to anti-glomerular basement membrane (GBM) glomerulonephritis
PG Tipping, NW Boyce, SR Holdsworth |
Clinical & Experimental Immunology | 1989 |
|
Immunohistochemical study of the membrane attack complex of complement and S-protein in idiopathic and secondary membranous nephropathy
KN Lai, ST Lo, FM Lai |
The American Journal of Pathology | 1989 |
|
Amastigotes of Trypanosoma cruzi escape destruction by the terminal complement components
K Iida, MB Whitlow, V Nussenzweig |
Journal of Experimental Medicine | 1989 |
|
Monoclonal antibodies to the apical chloride channel in Necturus gallbladder inhibit the chloride conductance
AL Finn, LM Tsai, RJ Falk |
Proceedings of the National Academy of Sciences | 1989 |
|
Immunohistochemical study of complement S protein (Vitronectin) in normal and diseased human kidneys: relationship to neoantigens of the C5b-9 terminal complex
J Bariety, N Hinglais, S Bhakdi, C Mandet, M Rouchon, MD Kazatchkine |
Clinical & Experimental Immunology | 1989 |
|
Localization of decay accelerating factor in normal and diseased kidneys
FG Cosio, DD Sedmak, JD Mahan, NS Nahman |
Kidney International | 1989 |
|
Secretion of the terminal complement proteins, C5–C9, by human platelets
JJ Houle, JP Leddy, SI Rosenfeld |
Clinical Immunology and Immunopathology | 1989 |
|
Localization of terminal complement components, S-protein and SP-40,40 in renal biopsies
BF Murphy, DJ Davies, W Morrow, AJ dApice |
Pathology | 1989 |
|
Diseases of the Arterial Wall
JP Camilleri, CL Berry, JN Fiessinger, J Bariéty |
1989 | |
|
Immunoelectron microscopic localization of membrane attack complex and hepatitis B e antigen in membranous nephropathy
N Akano, K Yoshioka, N Aya, H Miyamoto, T Takemura, M Tohda, S Maki |
Virchows Archiv A Pathological Anatomy and Histopathology | 1989 |
|
SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis
BF Murphy, L Kirszbaum, ID Walker, AJ d'Apice |
Journal of Clinical Investigation | 1988 |
|
Human peritoneal macrophages
G Hetland, L Bungum |
APMIS | 1988 |
|
Identification of a Human C5 beta-Chain Epitope Exposed in the Native Complement Component but Concealed in the SC5b-9 Complex
TE Mollnes, A Klos, J Tschopp |
Scandinavian Journal of Immunology | 1988 |
|
A sensitive method to detect synthesis of the functional classical, alternative and terminal pathway of complement by cells culturedin vitro
E Johnson, G Hetland |
Scandinavian Journal of Clinical & Laboratory Investigation | 1988 |
|
Mechanisms of hypertensive glomerular injury
JP Tolins, P Shultz, L Raij |
The American Journal of Cardiology | 1988 |
|
The relationship between macrophages and C5b-9 complement complexes in human atherosclerosis
HG Rus, F Niculescu, R Vlaicu |
Clinical Immunology and Immunopathology | 1988 |
|
Linear C3 Deposits on the Tubular Basement Membrane in Renal Allograft Biopsies
M Mathew, WK Bolton |
American Journal of Kidney Diseases | 1988 |
|
Immunohistochemical study of the membrane attack complex of complement in IgA nephropathy
H Miyamoto, K Yoshioka, T Takemura, N Akano, S Maki |
Virchows Archiv A Pathological Anatomy and Histopathology | 1988 |
|
Interactions of the platelets in paroxysmal nocturnal hemoglobinuria with complement. Relationship to defects in the regulation of complement and to platelet survival in vivo
DV Devine, RS Siegel, WF Rosse |
Journal of Clinical Investigation | 1987 |
|
Hypokalemic nephropathy in the rat. Role of ammonia in chronic tubular injury
JP Tolins, MK Hostetter, TH Hostetter |
Journal of Clinical Investigation | 1987 |
|
Activation of terminal components of complement in patients with Guillain-Barré syndrome and other demyelinating neuropathies
CL Koski, ME Sanders, PT Swoveland, TJ Lawley, ML Shin, MM Frank, KA Joiner |
Journal of Clinical Investigation | 1987 |
|
Cellular and non-cellular compositions of crescents in human glomerulonephritis
K Yoshioka, T Takemura, N Akano, H Miyamoto, T Iseki, S Maki |
Kidney International | 1987 |
|
Complement membrane attack (MAC) in idiopathic IgA-glomerulonephritis
EW Rauterberg, HM Lieberknecht, AM Wingen, E Ritz |
Kidney International | 1987 |
|
Immunohistochemical Detection of the Membrane and Fluid-phase Terminal Complement Complexes C5b-9(m) and SC5b-9
TE Mollnes, M Harboe |
Scandinavian Journal of Immunology | 1987 |
|
Localization of S protein and its relationship to the membrane attack complex of complement in renal tissue
RJ Falk, E Podack, AP Dalmasso, JC Jennette |
The American Journal of Pathology | 1987 |
|
Terminal complement complex in plasma from patients with systemic lupus erythematosus and other glomerular diseases
I Horigome, J Seino, K Sudo, Y Kinoshita, T Saito, K Yoshinaga |
Clinical & Experimental Immunology | 1987 |
|
Effect of differences in antibody and complement requirements on phagocytic uptake and intracellular killing of "c" protein-positive and -negative strains of type II group B streptococci
NR Payne, YK Kim, P Ferrieri |
Infection and immunity | 1987 |
|
Quantitative evaluation of the terminal C5b-9 complement complex by ELISA in human atherosclerotic arteries
F Niculescu, F Hugo, HG Rus, R Vlaicu, S Bhakdi |
Clinical & Experimental Immunology | 1987 |
|
Immunohistochemical studies of reflux nephropathy. The role of extracellular matrix, membrane attack complex, and immune cells in glomerular sclerosis
K Yoshioka, T Takemura, K Matsubara, H Miyamoto, N Akano, S Maki |
The American Journal of Pathology | 1987 |
|
Presence of C5b-9 complement complex and S-protein in human myocardial areas with necrosis and sclerosis
HG Rus, F Niculescu, R Vlaicu |
Immunology Letters | 1987 |
|
Formation of the Membrane Attack Complex of Complement (MAC) on Erythrocytes from Monocyte-Produced Terminal Complement Components
G Hetland, E Johnson, T Eskeland |
Scandinavian Journal of Immunology | 1987 |
|
Human Alveolar Macrophages Synthesize Active Complement Components C6, C7, and C8 in Vitro
HB Pettersen, E Johnson, G Hetland |
Scandinavian Journal of Immunology | 1987 |
|
Release of Leukotriene B4from Sublethally Injured Oligodendrocytes by Terminal Complement Complexes
Y Shirazi, DK Imagawa, ML Shin |
Journal of Neurochemistry | 1987 |
|
The classical pathway of complement prevents the formation of insoluble antigen — antibody complexes: biological implications
JA Schifferli |
Immunology Letters | 1987 |
|
A unique epitope exposed in native complement component C9 and hidden in the terminal SC5b-9 complex enables selective detection and quantification of non-activated C9
TE Mollnes, J Tschopp |
Journal of Immunological Methods | 1987 |
|
Complement in the Pathophysiology of Human Disease
MM Frank |
New England Journal of Medicine | 1987 |
|
Ultrastructural Localization of the Membrane Attack Complex of Complement in Human Renal Tissues
RJ Falk, SP Sisson, AP Dalmasso, Y Kim, AF Michael, RL Vernier |
American Journal of Kidney Diseases | 1987 |
|
Complement membrane attack complex stimulates production of reactive oxygen metabolites by cultured rat mesangial cells
S Adler, PJ Baker, RJ Johnson, RF Ochi, P Pritzl, WG Couser |
Journal of Clinical Investigation | 1986 |
|
Nature of the glomerular capillary injury in human membranous glomerulopathy
O Shemesh, JC Ross, WM Deen, GW Grant, BD Myers |
Journal of Clinical Investigation | 1986 |
|
Complement-induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy
AV Cybulsky, HG Rennke, ID Feintzeig, DJ Salant |
Journal of Clinical Investigation | 1986 |
|
Immunoelectron-microscopic localization of the terminal C5b-9 complement complex in human atherosclerotic fibrous plaque
HG Rus, F Niculescu, E Constantinescu, A Cristea, R Vlaicu |
Atherosclerosis | 1986 |
|
Immunohistochemical study of the C5b-9 complex of complement in human kidneys
N Hinglais, MD Kazatchkine, S Bhakdi, MD Appay, C Mandet, J Grossetete, J Bariety |
Kidney International | 1986 |
|
Immune complex induced glomerular lesions in C5 sufficient and deficient mice
RJ Falk, JC Jennette |
Kidney International | 1986 |
|
Studies of progressive glomerular sclerosis in the rat
S Adler, LJ Striker, GE Striker, DT Perkinson, J Hibbert, WG Couser |
The American Journal of Pathology | 1986 |
|
Restriction of the alternative pathway of human complement by intact Trypanosoma brucei subsp. gambiense
DV Devine, RJ Falk, AE Balber |
Infection and immunity | 1986 |
|
Immunohistochemical detection of the terminal C5b-9 complement complex in children with glomerular diseases
HG Rus, F Niculescu, M Nanulescu, A Cristea, P Florescu |
Clinical & Experimental Immunology | 1986 |
|
COMPLEMENT COMPONENT C9 IN GRAVES' DISEASE
DA Oleesky, S Ratanachaiyavong, M Ludgate, BP Morgan, AK Campbell, AM Mcgregor |
Clinical Endocrinology | 1986 |
|
Synthesis of Complement Components C5, C6, C7, C8 and C9 in Vitro by Human Monocytes and Assembly of the Terminal Complement Complex
G Hetland, E Johnson, RJ Falk, T Eskeland |
Scandinavian Journal of Immunology | 1986 |
|
Human Alveolar Macrophages Synthesize the Functional Alternative Pathway of Complement and Active C5 and C9 in Vitro
G Hetland, E Johnson, U AASEBo |
Scandinavian Journal of Immunology | 1986 |
|
The Role of Complement and Its Receptor in the Elimination of Immune Complexes
FH Epstein, JA Schifferli, YC Ng, DK Peters |
New England Journal of Medicine | 1986 |
|
Complement in the Pathophysiology and Diagnosis of Human Diseases
AP Dalmasso |
Critical Reviews in Clinical Laboratory Sciences | 1986 |
|
The Reticuloendothelial System
H Friedman, MR Escobar, SM Reichard, SM Phillips |
1986 | |
|
Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3
KA Nath, MK Hostetter, TH Hostetter |
Journal of Clinical Investigation | 1985 |
|
Role of terminal complement pathway in the heterologous phase of antiglomerular basement membrane nephritis
GC Groggel, DJ Salant, C Darby, HG Rennke, WG Couser |
Kidney International | 1985 |
|
Mechanisms of glomerular injury in immune-complex disease
WG Couser |
Kidney International | 1985 |
|
Complement and the direct mediation of immune glomerular injury: A new perspective
WG Couser, PJ Baker, S Adler |
Kidney International | 1985 |
|
Immunohistochemical localization of the terminal C5b-9 complement complex in human aortic fibrous plaque
R Vlaicu, F Niculescu, HG Rus, A Cristea |
Atherosclerosis | 1985 |
|
Membrane attack complex deposition in experimental glomerular injury
DT Perkinson, PJ Baker, WG Couser, RJ Johnson, S Adler |
The American Journal of Pathology | 1985 |
|
Lectin binding in membranoproliferative glomerulonephritis. Evidence for N-acetylglucosamine in dense intramembranous deposits
TE Nevins |
The American Journal of Pathology | 1985 |
|
Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion
D Jenne, KK Stanley |
The EMBO Journal | 1985 |
|
Monoclonal Antibodies Recognizing a Neoantigen of Poly(C9) Detect the Human Terminal Complement Complex in Tissue and Plasma
TE Mollnes, T Lea, M Harboe, J Tschopp |
Scandinavian Journal of Immunology | 1985 |
|
Localization of the terminal C5b-9 complement complex in the human aortic atherosclerotic wall
F Niculescu, H Rus, A Cristea, R Vlaicu |
Immunology Letters | 1985 |
|
Quantitation of activation of the human terminal complement pathway by ELISA
ME Sanders, MA Schmetz, CH Hammer, MM Frank, KA Joiner |
Journal of Immunological Methods | 1985 |
|
Radioimmunoassay of the Attack Complex of Complement in Serum from Patients with Systemic Lupus Erythematosus
RJ Falk, AP Dalmasso, Y Kim, S Lam, A Michael |
New England Journal of Medicine | 1985 |
|
The membrane attack complex
HJ Müller-Eberhard |
Springer Seminars in Immunopathology | 1984 |
|
Detection of terminal complement components in experimental immune glomerular injury
S Adler, PJ Baker, P Pritzl, WG Couser |
Kidney International | 1984 |
|
Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats
L Raij, S Azar, W Keane |
Kidney International | 1984 |
|
Do genetic factors play a role in the pathogenesis of diabetic microangiopathy?
J Barbosa, B Saner |
Diabetologia | 1984 |
|
Deposition of the Membrane Attack Complex of Complement in Bullous Pemphigoid
MV Dahl, RJ Falk, R Carpenter, AF Michael |
Journal of Investigative Dermatology | 1984 |
|
Complement channels in membranes: Inhibition with a monoclonal antibody to a neoantigen of polymerized C9
AP Dalmasso, BA Benson, RJ Falk |
Biochemical and Biophysical Research Communications | 1984 |
|
Detection and Quantification of the Terminal C5b-9 Complex of Human Complement by a Sensitive Enzyme-Linked Immunosorbent Assay
TE Mollnes, T Lea, M Harboe |
Scandinavian Journal of Immunology | 1984 |
|
Cell populations and membrane attack complex in glomeruli of patients with post-streptococcal glomerulonephritis: Identification using monoclonal antibodies by indirect immunofluorescence
G Parra, JL Platt, RJ Falk, B Rodriguez-Iturbe, AF Michael |
Clinical Immunology and Immunopathology | 1984 |
|
Contemporary Nephrology
S Klahr, SG Massry |
1981 | |
|
Progress in Immunology
IH Lepow |
Progress in Immunology | 1971 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)