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Citations to this article

Characterization of Serum Resistance of Neisseria gonorrhoeae that Disseminate: ROLES OF BLOCKING ANTIBODY AND GONOCOCCAL OUTER MEMBRANE PROTEINS
Peter A. Rice, Dennis L. Kasper
Peter A. Rice, Dennis L. Kasper
Published July 1, 1982
Citation Information: J Clin Invest. 1982;70(1):157-167. https://doi.org/10.1172/JCI110589.
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Characterization of Serum Resistance of Neisseria gonorrhoeae that Disseminate: ROLES OF BLOCKING ANTIBODY AND GONOCOCCAL OUTER MEMBRANE PROTEINS

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Abstract

Neisseria gonorrhoeae isolated from patients with disseminated infection (DGI) often resist complement (C′)-dependent killing by normal human serum (NHS) and less commonly by convalescent DGI serum. 7 of 10 NHS specimens completely inhibited killing of serum-resistant (serr) gonococci by convalescent or immune DGI serum. Immunoglobulin G (IgG) purified from NHS was shown to be the blocking agent. In addition, IgM (plus C′) purified from NHS was shown to be fivefold more effective (wt/wt) in killing serum-sensitive (sers) gonococci than equivalent amounts of IgM tested in the presence of IgG (whole serum). Although inhibition of NHS killing of sers gonococci required a 640% excess of IgG, only a 40% excess was required to block immune serum killing of serr gonococci. F(ab′)2 prepared from IgG also blocked killing of serr gonococci by immune serum indicating antigenic specificity of blocking IgG.

Authors

Peter A. Rice, Dennis L. Kasper

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Year: 2024 2023 2021 2020 2019 2016 2012 2011 2010 2008 2005 2004 2003 2002 2001 2000 1998 1996 1995 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 Total
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Citations to this article (59)

Title and authors Publication Year
Mechanisms of antibody-dependent enhancement of infectious disease.
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Nature reviews. Immunology 2024
Gonococcal PorB: a multifaceted modulator of host immune responses
Jones RA, Jerse AE, Tang CM
Trends in Microbiology 2024
Mechanisms of host manipulation by Neisseria gonorrhoeae
Walker E, van Niekerk S, Hanning K, Kelton W, Hicks J
Frontiers in microbiology 2023
Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence
Gulati S, Mattsson AH, Schussek S, Zheng B, DeOliveira RB, Shaughnessy J, Lewis LA, Rice PA, Comstedt P, Ram S
mBio 2023
Antibody-Dependent Enhancement of Bacterial Disease: Prevalence, Mechanisms, and Treatment
VV Torres, CF Coggon, TJ Wells, AR Richardson
Infection and immunity 2021
Complement interactions with the pathogenic Neisseriae: clinical features, deficiency states, and evasion mechanisms
LA Lewis, S Ram
FEBS Letters 2020
Human Immune Responses and the Natural History of Neisseria gonorrhoeae Infection
A Lovett, JA Duncan
Frontiers in immunology 2019
Gonorrhea – an evolving disease of the new millennium
SA Hill, TL Masters, J Wachter
Microbial Cell 2016
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz
Protein Engineering for Therapeutics Part B 2012
Advances in Clinical Chemistry
M Mahler
Advances in Clinical Chemistry Volume 54 2011
Resistance of Neisseria gonorrhoeae to neutrophils
MB Johnson, AK Criss
Frontiers in microbiology 2011
Gonococcal Infections
JE Embree
Infectious Diseases of the Fetus and Newborn 2011
Antibiotic and Chemotherapy
P Moss
Antibiotic and Chemotherapy 2010
An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseriagonorrhoeae
S Agarwal, VP Ferreira, C Cortes, MK Pangburn, PA Rice, S Ram
Journal of immunology (Baltimore, Md. : 1950) 2010
The role of complement in gonococcal infection of cervical epithelia
JL Edwards
Vaccine 2008
Mucosal Immunology
WR Brown
Mucosal Immunology 2005
The Molecular Mechanisms Used by Neisseria gonorrhoeae To Initiate Infection Differ between Men and Women
JL Edwards, MA Apicella
Clinical microbiology reviews 2004
Musculoskeletal Infections
M Shirtliff, J Leid, J Costerton
Musculoskeletal Infections 2003
Acute septic arthritis
ME Shirtliff, JT Mader
Clinical microbiology reviews 2002
High Affinity Mimotope of the Polysaccharide Capsule of Cryptococcus neoformans Identified from an Evolutionary Phage Peptide Library
DO Beenhouwer, RJ May, P Valadon, MD Scharff
Journal of immunology (Baltimore, Md. : 1950) 2002
Strategies for Mimicking Neisserial Saccharide Epitopes as Vaccines
S Gulati, J Ngampasutadol, R Yamasaki, DP McQuillen, PA Rice
International Reviews of Immunology 2001
Molecular Mimicry, Microbes, and Autoimmunity
MW Cunningham, RS Fujinami
2000
Binding of complement factor H to loop 5 of porin protein 1A: a molecular mechanism of serum resistance of nonsialylated Neisseria gonorrhoeae
S Ram, DP McQuillen, S Gulati, C Elkins, MK Pangburn, PA Rice
Journal of Experimental Medicine 1998
GONOCOCCAL ARTHRITIS
E Cucurull, LR Espinoza
Rheumatic Disease Clinics of North America 1998
Binding of Complement Factor H to Loop 5 of Porin Protein 1A: A Molecular Mechanism of Serum Resistance of Nonsialylated Neisseria gonorrhoeae
S Ram, DP McQuillen, S Gulati, C Elkins, MK Pangburn, PA Rice
Journal of Experimental Medicine 1998
Systemic gonococcal infection
JD Ross
Genitourinary medicine 1996
Neisserial porins inhibit human neutrophil actin polymerization, degranulation, opsonin receptor expression, and phagocytosis but prime the neutrophils to increase their oxidative burst
R Bjerknes, HK Guttormsen, CO Solberg, LM Wetzler
Infection and immunity 1995
Complement Activation and Sensitizing Antibodies in Lyme Borreliosis. A Microbial Adherence Immobilization Assay for Borrelia burgdorferi (MAIA-BB)
B Cacciapuoti, L Ciceroni, L Fontana, R Perricone
Zentralblatt für Bakteriologie 1993
The Complement System
A Agostoni, M Cicardi, M Gardinali, L Bergamaschini
International journal of immunopathology and pharmacology 1992
Emerging Targets in Antibacterial and Antifungal Chemotherapy
JA Sutcliffe, NH Georgopapadakou
1992
Infectious diseases associated with complement deficiencies
JE Figueroa, P Densen
Clinical microbiology reviews 1991
Binding of S protein by Neisseria gonorrhoeae and potential role in invasion
RJ Arko, CY Chen, WO Schalla, SK Sarafian, CL Taylor, JS Knapp, SA Morse
Journal of clinical microbiology 1991
Gonococcal Endocarditis: Twenty-Five Year Experience
JD Jackman, DB Glamann
The American Journal of the Medical Sciences 1991
Septic arthritis
RJ Williams, RL Smith, DJ Schurman
Arthritis & Rheumatism 1990
Lacto- and ganglio-series glycolipids are adhesion receptors for Neisseria gonorrhoeae
CD Deal, HC Krivan
The Journal of biological chemistry 1990
Interaction of complement with Neisseria meningitidis and Neisseria gonorrhoeae
P Densen
Clinical microbiology reviews 1989
Interactions of Neisseria gonorrhoeae with human neutrophils
RF Rest, WM Shafer
Clinical microbiology reviews 1989
Molecular basis for serum resistance in Neisseria gonorrhoeae
PA Rice
Clinical microbiology reviews 1989
Sexually Transmitted Infections: Current Epidemiological Perspective on World-Wide Infections with Aspects on Transmission, Molecular Biology, Epidemiological Control and Prevention
D Danielsson, E Lycke
Scandinavian Journal of Infectious Diseases 1989
The construction and characterization of Neisseria gonorrhoeae lacking protein III in its outer membrane
L M Wetzler, E C Gotschlich, M S Blake, J M Koomey
Journal of Experimental Medicine 1989
Characterization and specificity of antibodies to protein I of Neisseria gonorrhoeae produced by injection with various protein I-adjuvant preparations
LM Wetzler, MS Blake, EC Gotschlich
Journal of Experimental Medicine 1988
Gonococci and Meningococci
JT Poolman
1988
Specificity of antibodies against Neisseria gonorrhoeae that stimulate neutrophil chemotaxis. Role of antibodies directed against lipooligosaccharides
P Densen, S Gulati, PA Rice
Journal of Clinical Investigation 1987
Physical heterogeneity of neisserial lipooligosaccharides reflects oligosaccharides that differ in apparent molecular weight, chemical composition, and antigenic expression
JM Griffiss, JP O'Brien, R Yamasaki, GD Williams, PA Rice, H Schneider
Infection and immunity 1987
Mechanisms of stable serum resistance of Neisseria gonorrhoeae
PA Rice, MS Blake, KA Joiner
Antonie van Leeuwenhoek 1987
Immunoglobulin G antibodies directed against protein III block killing of serum-resistant Neisseria gonorrhoeae by immune serum
PA Rice, HE Vayo, MR Tam, MS Blake
Journal of Experimental Medicine 1986
Protection by serum antibodies in experimental nontypable Haemophilus influenzae otitis media
SJ Barenkamp
Infection and immunity 1986
Antigenic and physical diversity of Neisseria gonorrhoeae lipooligosaccharides
R Mandrell, H Schneider, M Apicella, W Zollinger, PA Rice, JM Griffiss
Infection and immunity 1986
Characterization of antigens from nontypable Haemophilus influenzae recognized by human bactericidal antibodies. Role of Haemophilus outer membrane proteins
HE Gnehm, SI Pelton, S Gulati, PA Rice
Journal of Clinical Investigation 1985
Mechanism of action of blocking immunoglobulin G for Neisseria gonorrhoeae
KA Joiner, R Scales, KA Warren, MM Frank, PA Rice
Journal of Clinical Investigation 1985
Antigenic heterogeneity of lipid A of Haemophilus influenzae
MA Apicella, KC Dudas, A Campagnari, P Rice, JM Mylotte, TF Murphy
Infection and immunity 1985
Antigenic heterogeneity of outer membrane proteins of nontypable Haemophilus influenzae is a basis for a serotyping system
TF Murphy, MA Apicella
Infection and immunity 1985
Gonococcal Infection: A Model of Molecular Pathogenesis
BE Britigan, MS Cohen, PF Sparling
New England Journal of Medicine 1985
The Pathogenesis of Bacterial Infections
GG Jackson, H Thomas
1985
Bacteria and Complement
M Loos
1985
Elaboration of a 3.6-kilodalton lipooligosaccharide, antibody against which is absent from human sera, is associated with serum resistance of Neisseria gonorrhoeae
H Schneider, JM Griffiss, RE Mandrell, GA Jarvis
Infection and immunity 1985
Generation and characterization of monoclonal antibodies to the phenolic glycolipid of Mycobacterium leprae
DB Young, SR Khanolkar, LL Barg, TM Buchanan
Infection and immunity 1984
Immunoglobulin A from bronchopulmonary secretions blocks bactericidal and opsonizing effects of antibody to nontypable Haemophilus influenzae
DM Musher, A Goree, RE Baughn, HH Birdsall
Infection and immunity 1984
The role of complement in host resistance to bacteria
EJ Brown, KA Joiner, MM Frank
Springer Seminars in Immunopathology 1983

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