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Citations to this article

Glucocorticoid-induced Insulin Resistance: THE IMPORTANCE OF POSTBINDING EVENTS IN THE REGULATION OF INSULIN BINDING, ACTION, AND DEGRADATION IN FRESHLY ISOLATED AND PRIMARY CULTURES OF RAT HEPATOCYTES
Jose F. Caro, John M. Amatruda
Jose F. Caro, John M. Amatruda
Published April 1, 1982
Citation Information: J Clin Invest. 1982;69(4):866-875. https://doi.org/10.1172/JCI110526.
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Glucocorticoid-induced Insulin Resistance: THE IMPORTANCE OF POSTBINDING EVENTS IN THE REGULATION OF INSULIN BINDING, ACTION, AND DEGRADATION IN FRESHLY ISOLATED AND PRIMARY CULTURES OF RAT HEPATOCYTES

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Abstract

We have recently proposed that “down regulation” of the insulin receptor may be one of the many biological responses of a cell to insulin. In an attempt to further explore this hypothesis we have studied insulin action, binding, and degradation in freshly isolated hepatocytes from rats rendered insulin resistant by the administration of dexamethasone, 1.0 mg/kg every other day, for 1 and 4 wk, and in dexamethasone-treated (0.1 μM for 24 h) primary cultures of hepatocytes from normal rats.

Authors

Jose F. Caro, John M. Amatruda

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Year: 2019 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 1998 1997 1996 1995 1994 1993 1992 1990 1989 1988 1987 1986 1985 1984 1983 1982 Total
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