We have recently proposed that “down regulation” of the insulin receptor may be one of the many biological responses of a cell to insulin. In an attempt to further explore this hypothesis we have studied insulin action, binding, and degradation in freshly isolated hepatocytes from rats rendered insulin resistant by the administration of dexamethasone, 1.0 mg/kg every other day, for 1 and 4 wk, and in dexamethasone-treated (0.1 μM for 24 h) primary cultures of hepatocytes from normal rats.
Jose F. Caro, John M. Amatruda
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The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease | 2016 |
Hypothalamic innate immune reaction in obesity
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Nature Reviews Endocrinology | 2015 |
Treating posttransplantation diabetes mellitus
MJ Pérez-Sáez, M Marín-Casino, J Pascual |
Expert Opinion on Pharmacotherapy | 2015 |
Comprehensive Physiology
SN Cheuvront, RW Kenefick |
Comprehensive Physiology | 2014 |
The hypothalamic neural–glial network and the metabolic syndrome
M Jastroch, S Morin, MH Tschöp, CX Yi |
Best Practice & Research Clinical Endocrinology & Metabolism | 2014 |
Dubois' Lupus Erythematosus and Related Syndromes
JC Crispín, GC Tsokos |
Dubois' Lupus Erythematosus and Related Syndromes | 2013 |
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MP Khan, JS Mishra, K Sharan, M Yadav, AK Singh, A Srivastava, S Kumar, S Bhaduaria, R Maurya, S Sanyal, N Chattopadhyay |
Phytomedicine | 2013 |
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T Matsubara, A Mita, K Minami, T Hosooka, S Kitazawa, K Takahashi, Y Tamori, N Yokoi, M Watanabe, E Matsuo, O Nishimura, S Seino |
Cell Metabolism | 2012 |
Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor
M Surjit, KP Ganti, A Mukherji, T Ye, G Hua, D Metzger, M Li, P Chambon |
Cell | 2011 |
Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice
M Warrier, TD Hinds, KJ Ledford, HA Cash, PR Patel, TA Bowman, LA Stechschulte, W Yong, W Shou, SM Najjar, ER Sanchez |
Endocrinology | 2010 |
Short-term glucocorticoid intake improves exercise endurance in healthy recreationally trained women
B Panse, R Thomasson, L Jollin, AM Lecoq, V Amiot, N Rieth, J Ceaurriz, K Collomp |
European Journal of Applied Physiology | 2009 |
The passive coping Roman Low Avoidance rat, a non-obese rat model for insulin resistance
GJ Boersma, AJ Scheurink, PY Wielinga, TJ Steimer, L Benthem |
Physiology & Behavior | 2009 |
Effects of short-term corticoid ingestion on food intake and adipokines in healthy recreationally trained men
N Rieth, L Jollin, B Panse, AM Lecoq, A Arlettaz, J Ceaurriz, K Collomp |
European Journal of Applied Physiology | 2008 |
Effects of Short-Term Prednisolone Intake during Submaximal Exercise
A Arlettaz, H Portier, AM Lecoq, N Rieth, JD Ceaurriz, K Collomp |
Medicine & Science in Sports & Exercise | 2007 |
Gymnemic Acids fromGymnema sylvestre. Potentially Regulates Dexamethasone-Induced Hyperglycemia in Mice
S Gholap, A Kar |
Pharmaceutical Biology | 2005 |
Serum insulin concentrations in horses with equine Cushing's syndrome: response to a cortisol inhibitor and prognostic value
CM Mcgowan, R Frost, DU Pfeiffer, R Neiger |
Equine Veterinary Journal | 2004 |
Efficacy of Some Plant Extracts in Regulating Corticosteroid-Induced Hyperglycaemia in Mice
S Gholap, A Kar |
Pharmaceutical Biology | 2003 |
Differential modulation of insulin actions by dexamethasone: studies in primary cultures of adult rat hepatocytes
HH Klein, S Ullmann, M Drenckhan, T Grimmsmann, K Unthan-Fechner, I Probst |
Journal of Hepatology | 2002 |
Effect of glucocorticoid excess on skeletal muscle and heart protein synthesis in adult and old rats
I Savary, E Debras, D Dardevet, C Sornet, P Capitan, J Prugnaud, PP Mirand, J Grizard |
British Journal of Nutrition | 1998 |
DIABETES MANAGEMENT IN SPECIAL SITUATIONS
IB Hirsch, DS Paauw |
Endocrinology & Metabolism Clinics of North America | 1997 |
Insulin receptor/IRS-1/PI 3-kinase signaling system in corticosteroid-induced insulin resistance
F Folli, MJ Saad, CR Kahn |
Acta Diabetologica | 1996 |
Effect of lipectomy and long-term dexamethasone on visceral fat and metabolic variables in rats
E Palacios, MJ Piñon-López, IS Racotta, R Racotta |
Metabolism | 1995 |
Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients
L Luzi, A Battezzati, G Perseghin, E Bianchi, I Terruzzi, D Spotti, S Vergani, A Secchi, EL Rocca, G Ferrari |
Journal of Clinical Investigation | 1994 |
Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo
F Giorgino, A Almahfouz, LJ Goodyear, RJ Smith |
Journal of Clinical Investigation | 1993 |
Glucocorticoid induction of epinephrine synthesizing enzyme in rat skeletal muscle and insulin resistance
B Kennedy, H Elayan, MG Ziegler |
Journal of Clinical Investigation | 1993 |
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats
MJ Saad, F Folli, JA Kahn, CR Kahn |
Journal of Clinical Investigation | 1993 |
Modulation of insulin like growth factor I (IGF-I) binding sites on erythrocytes by IGF-I treatment in patients with Laron syndrome (LS)
R Eshet, B Klinger, A Silbergeld, Z Laron |
Regulatory Peptides | 1993 |
8 Drug-induced diabetes
RE Ferner |
Baillière's Clinical Endocrinology and Metabolism | 1992 |
Dexamethasone effects on creatine kinase activity and insulin-like growth factor receptors in cultured muscle cells
PA Whitson, CA Stuart, MH Huls, CF Sams, NM Cintron |
Journal of Cellular Physiology | 1989 |
Hormone and substrate regulation of glycogen accumulation in primary cultures of rat hepatocytes
AI Salhanick, CL Chang, JM Amatruda |
Biochemical Journal | 1989 |
Sensitization of Human Fibroblasts to Insulin-Like Growth Factor I by Serum Deprivation and Dexamethasone Pretreatment
E Heath-monnig, WH Daughaday |
Endocrine Research | 1989 |
Effects of glucocorticoids on carbohydrate metabolism
M Mcmahon, J Gerich, R Rizza |
Diabetes / Metabolism Reviews | 1988 |
Insulin Resistance: A Look at the Role of Insulin Receptor Kinase
SS Reddy, CR Kahn |
Diabetic Medicine | 1988 |
GLUCOCORTICOIDS AND GLUCOSE METABOLISM: HEPATIC GLUCOSE PRODUCTION IN UNTREATED ADDISONIAN PATIENTS AND ON TWO DIFFERENT LEVELS OF GLUCOCORTICOID ADMINISTRATION
D Malerbi, B Liberman, A Giurno-Filho, D Giannellaneto, BL Wajchenberg |
Clinical Endocrinology | 1988 |
Short- and longer-term regulation of very-low-density lipoprotein secretion by insulin, dexamethasone and lipogenic substrates in cultured hepatocytes. A biphasic effect of insulin
SM Bartlett, GF Gibbons |
Biochemical Journal | 1988 |
Glucocorticoid receptor-dependent inhibition of cellular proliferation in dexamethasone-resistant and hypersensitive rat hepatoma cell variants
P W Cook, K T Swanson, C P Edwards, G L Firestone |
Molecular and cellular biology | 1988 |
The effect of dexamethasone on B cell mass and function in partial pancreatctomized rats
H C Lee, K B Huh |
The Korean Journal of Internal Medicine | 1988 |
Regulation of amino acid transport in isolated rat hepatocytes during development
S Leoni, S Spagnuolo, L Dini, LC Devirgiliis |
Journal of Cellular Physiology | 1987 |
Effects of gluconeogenic hormones on insulin binding in intact human red blood cells
L Mokoena, M Alberts, E Tyobeka |
Biochemical and Biophysical Research Communications | 1987 |
Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity
JF Caro, O Ittoop, WJ Pories, D Meelheim, EG Flickinger, F Thomas, M Jenquin, JF Silverman, PG Khazanie, MK Sinha |
Journal of Clinical Investigation | 1986 |
Effect of dexamethasone on hepatic glucose and insulin metabolism after oral glucose in conscious dogs
Z Chap, RH Jones, J Chou, CJ Hartley, ML Entman, JB Field |
Journal of Clinical Investigation | 1986 |
Insulin resistance in uremia: In vitro model in the rat liver using human serum to study mechanisms
F Folli, MK Sinha, D Brancaccio, JF Caro |
Metabolism | 1986 |
Insulin binding to differentiating muscle cell line L6
N Watanabe, M Kobayashi, M Iwasaki, O Ishibashi, Y Takata, Y Shigeta |
Diabetes Research and Clinical Practice | 1986 |
Control and Manipulation of Animal Growth
V Oddy, D Lindsay |
Control and Manipulation of Animal Growth | 1986 |
Induction of the insulin proreceptor by hydrocortisone in cultured lymphocytes (IM-9 line)
DG Rouiller, A McElduff, JA Hedo, P Gorden |
Journal of Clinical Investigation | 1985 |
Hormonal control of cholesterogenesis and related enzymes in isolated rat hepatocytes during pre- and postnatal development
S Leoni, S Spagnuolo, LC Devirgiliis, L Dini, MT Mangiantini, A Trentalance |
Journal of Cellular Physiology | 1985 |
Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure
JM Amatruda, JN Livingston, DH Lockwood |
Diabetes / Metabolism Reviews | 1985 |
Pathogenesis of impaired glucose tolerance and type II diabetes mellitus--current status
MB Davidson |
The Western journal of medicine | 1985 |
The effect of glucocorticoid on 125I-insulin binding to human erythrocytes Possible postreceptor modulation of receptor binding
KU Lee, SY Kim, HK Lee, HK Min |
Diabetes Research and Clinical Practice | 1985 |
The hepatic glucocorticoid domain: evidence for early and late hormone-mediated changes in the synthesis of individual protein gene products
RA Colbert, JM Amatruda, DA Young |
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | 1985 |
Insulin resistance: Receptor and post-binding defects in human obesity and non-insulin-dependent diabetes mellitus
JA Truglia, JN Livingston, DH Lockwood |
The American Journal of Medicine | 1985 |
Normal hepatic insulin receptor autophosphorylation in nonketotic diabetes mellitus
JM Amatruda, AM Roncone |
Biochemical and Biophysical Research Communications | 1985 |
INSULIN RESISTANCE IN CIRRHOSIS: EVIDENCE FOR A POST-RECEPTOR DEFECT
J Proietto, A Nankervis, P Aitken, FJ Dudley, G Caruso, FP Alford |
Clinical Endocrinology | 1984 |
The effects of chronic uremia on glucagon binding and action in isolated rat hepatocytes
TG Helinek, S Sadel, JF Caro |
Metabolism | 1984 |
Insulin resistance in the aged: A quantitative evaluation of in vivo insulin sensitivity and in vitro glucose transport
G Pagano, M Cassader, P Cavallo-Perin, A Bruno, P Masciola, A Ozzello, AM Dall'Omo, A Foco |
Metabolism | 1984 |
Effects of changes in serum insulin in response to dexamethasone and adrenalectomy on insulin-sensitive phosphodiesterase in rat fat cells
M Osegawa, H Makino, A Kanatsuka, T Suzuki, S Yoshida |
Metabolism | 1984 |
Diabetes Mellitus Associated with Other Endocrine Disorders
JE Eigenmann, ME Peterson |
Veterinary Clinics of North America Small Animal Practice | 1984 |
Insulin resistance in uremia. Characterization of insulin action, binding, and processing in isolated hepatocytes from chronic uremic rats
JM Kauffman, JF Caro |
Journal of Clinical Investigation | 1983 |
Insulin resistance in uremia. Characterization of lipid metabolism in freshly isolated and primary cultures of hepatocytes from chronic uremic rats
JF Caro, S Lanza-Jacoby |
Journal of Clinical Investigation | 1983 |
An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects
G Pagano, P Cavallo-Perin, M Cassader, A Bruno, A Ozzello, P Masciola, AM Dall'omo, B Imbimbo |
Journal of Clinical Investigation | 1983 |
The effects of glucocorticoids on insulin-stimulated lipogenesis in primary cultures of rat hepatocytes
JM Amatruda, SA Danahy, CL Chang |
Biochemical Journal | 1983 |
Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus
DH Lockwood, JM Amatruda |
The American Journal of Medicine | 1983 |
Hypoglycemia Associated with Antibodies to the Insulin Receptor
SI Taylor, G Grunberger, B Marcus-Samuels, LH Underhill, RF Dons, J Ryan, RF Roddam, CE Rupe, P Gorden |
New England Journal of Medicine | 1982 |
The establishment of insulin resistance model in FL83B and L6 cell
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2ND INTERNATIONAL CONFERENCE ON MATERIALS SCIENCE, RESOURCE AND ENVIRONMENTAL ENGINEERING (MSREE 2017) | |
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The effect of acute and short term glucocorticoid administration on exercise capacity and metabolism
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Journal of Science and Medicine in Sport | 2017 |
Short-term glucocorticoid intake improves exercise endurance in healthy recreationally trained women
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European Journal of Applied Physiology | 2009 |
Modulation of Bone Morphogenetic Protein-9 Expression and Processing by Insulin, Glucose, and Glucocorticoids: Possible Candidate for Hepatic Insulin-Sensitizing Substance
LC Caperuto, GF Anhê, TD Cambiaghi, EH Akamine, D do Carmo Buonfiglio, J Cipolla-Neto, R Curi, S Bordin |
Endocrinology | 2008 |
Effects of short-term corticoid ingestion on food intake and adipokines in healthy recreationally trained men
N Rieth, L Jollin, BL Panse, AM Lecoq, A Arlettaz, JD Ceaurriz, K Collomp |
European Journal of Applied Physiology | 2008 |
Abnormalities of Glucose Homeostasis and the Hypothalamic-Pituitary-Adrenal Axis in Mice Lacking Hexose-6-Phosphate Dehydrogenase
D Rogoff, JW Ryder, K Black, Z Yan, SC Burgess, DR McMillan, PC White |
Endocrinology | 2007 |
Distinct Regulation of IRS Proteins in Adipose Tissue from Obese Aged and Dexamethasone-Treated Rats
LC Caperuto, GF Anhê, AM Amanso, LM Ribeiro, MC Medina, LC Souza, OM Carvalho, S Bordin, MJ Saad, CR Carvalho |
Endocrine | 2006 |
Absence of insulin-receptor downregulation in hepatocytes from hyperinsulinemic rats
S Bottomley, P Garcia-Webb |
American journal of physiology. Endocrinology and metabolism | 1990 |
Hormonal regulation of insulin receptor gene expression. Hydrocortisone and insulin act by different mechanisms
DG Rouiller, C McKeon, SI Taylor, P Gorden |
The Journal of biological chemistry | 1988 |
Effect of fasting and dexamethasone on binding characteristics of canine erythrocyte insulin receptors
G Dieberg, J Sartin, R Kemppainen, E OLIVER |
Research in Veterinary Science | 1986 |
Pathogenesis and Treatment of Diabetes Mellitus
JK Radder, HH Lemkes, HM Krans |
1986 | |
The acute and chronic effects of glucocorticoids on insulin receptor and insulin responsiveness. Transient fluctuations in intracellular receptor level parallel transient fluctuations in responsiveness
VP Knutson |
The Journal of biological chemistry | 1986 |
Regulation of insulin binding and glycogenesis by insulin and dexamethasone in cultured rat hepatocytes
WE Fleig, G Nöther-Fleig, S Steudter, D Enderle, H Ditschuneit |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 1985 |
The mechanisms of up-regulation of the hepatic insulin receptor in hypoinsulinemic diabetes mellitus
AI Salhanick, H West, JM Amatruda |
The Journal of biological chemistry | 1985 |
An endogenous substrate for the insulin receptor-associated tyrosine kinase
RW Rees-Jones, SI Taylor |
The Journal of biological chemistry | 1985 |
Effect of prolactin and glucocorticoids on P-enolpyruvate carboxykinase activity in liver and mammary gland from diabetic and lactating rats
MF Lobato, M Careche, M Ros, FJ Moreno, JP Garca-Ruz |
Molecular and Cellular Biochemistry | 1985 |
Decreased insulin sensitivity and glucose tolerance in spontaneous canine hyperadrenocorticism
ME Peterson, N Altszuler, CE Nichols |
Research in Veterinary Science | 1984 |
Equilibrium model for insulin-induced receptor down-regulation. Regulation of insulin receptors in differentiated BC3H-1 myocytes
ML Standaert, RJ Pollet |
The Journal of biological chemistry | 1984 |
Is glycosylation in the liver needed for insulin binding, processing, and action? Evidence for heterogeneity
JF Caro, F Cecchin, MK Sinha |
The Journal of biological chemistry | 1984 |
Dexamethasone stimulates insulin receptor synthesis in cultured rat hepatocytes
AI Salhanick, MN Krupp, JM Amatruda |
The Journal of biological chemistry | 1983 |
Hepatocyte insulin binding and action in rats with sommatomammotrophic tumours
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Diabetologia | 1983 |