Glucocorticoid-induced Insulin Resistance: THE IMPORTANCE OF POSTBINDING EVENTS IN THE REGULATION OF INSULIN BINDING, ACTION, AND DEGRADATION IN FRESHLY ISOLATED AND PRIMARY CULTURES OF RAT HEPATOCYTES

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Abstract

We have recently proposed that “down regulation” of the insulin receptor may be one of the many biological responses of a cell to insulin. In an attempt to further explore this hypothesis we have studied insulin action, binding, and degradation in freshly isolated hepatocytes from rats rendered insulin resistant by the administration of dexamethasone, 1.0 mg/kg every other day, for 1 and 4 wk, and in dexamethasone-treated (0.1 μM for 24 h) primary cultures of hepatocytes from normal rats.

Authors

Jose F. Caro, John M. Amatruda