Citations to this article

Impairment of the Growth of Plasmodium Falciparum in HbEE Erythrocytes
Ronald L. Nagel, … , Mary E. Fabry, Herbert Tanowitz
Ronald L. Nagel, … , Mary E. Fabry, Herbert Tanowitz
Published July 1, 1981
Citation Information: J Clin Invest. 1981;68(1):303-305. https://doi.org/10.1172/JCI110248.
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Impairment of the Growth of Plasmodium Falciparum in HbEE Erythrocytes

Abstract

HbE is a β-chain mutant frequently found among inhabitants of Southeast Asia and surrounding territories. We find that Plasmodium falciparum multiplies more slowly in erythrocytes from individuals homozygous for HbE than in cells from HbA individuals. In contrast, this parasite grows normally in erythrocytes heterozygous for HbE. This is the first direct evidence that suggests what has been suspected on the basis of circumstantial data, that HbE-containing erythrocytes might be advantageous to the carrier in regions with endemic malaria.

Authors

Ronald L. Nagel, Carmen Raventos-Suarez, Mary E. Fabry, Herbert Tanowitz

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Citations to this article (37)

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