Citations to this article

Increase of adipose tissue lipoprotein lipase activity with weight loss.
R S Schwartz, J D Brunzell
R S Schwartz, J D Brunzell
Published May 1, 1981
Citation Information: J Clin Invest. 1981;67(5):1425-1430. https://doi.org/10.1172/JCI110171.
View: Text | PDF
Research Article

Increase of adipose tissue lipoprotein lipase activity with weight loss.

Abstract

Obese subjects have elevated adipose tissue lipoprotein lipase activity per fat cell when compared with lean control subjects. This enzyme, which is rate limiting for the uptake and storage of lipoprotein triglyceride in adipose tissue, has been shown to be further elevated in a group of previously obese subjects who had been weight stable at a reduced weight for 4-28 mo. In the present prospective study of eight obese subjects, adipose tissue lipoprotein lipase activity was demonstrated to increase after weight stabilization at a reduced weight (0.33 mU/10(6) cells). In three subjects who lost weight and subsequently regained their lost weight, the enzyme activity increased after weight loss and then returned toward the original basal level with weight gain. One subject who maintained his weight loss for 10 mo. continued to have an elevated level of enzyme activity. Because adipose tissue lipoprotein lipase activity does not "normalize" after weight loss, we hypothesize that this enzyme may play a counterregulatory role in resisting deviation from a "set point" for fat mass or fat cell size and thereby predispose to reattainment of the original obese state.

Authors

R S Schwartz, J D Brunzell

×

Total citations by year

Year: 2025 2024 2022 2021 2020 2019 2017 2015 2014 2013 2011 2010 2009 2007 2004 2003 2002 2001 2000 1999 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 Total
Citations: 1 1 1 2 1 2 1 1 6 2 2 5 4 2 2 1 2 1 1 3 5 2 6 1 3 2 1 5 7 4 10 2 5 5 4 6 109
Citation information

Citations to this article (109)

Title and authors Publication Year
Exploring Urtica dioica L. as a Promising Alternative Therapy for Obesity-Related Breast Cancer: Insights from Molecular Mechanisms and Bioinformatic Analysis
Eren A, Varol M, Unal R, Altan F 		Plant Foods for Human Nutrition (Dordrecht, Netherlands) 2025
The past, present, and future of behavioral obesity treatment.
Chao AM, Moore M, Wadden TA 		International Journal of Obesity 2024
Reinvention of hermaphroditism via activation of a RADIALIS-like gene in hexaploid persimmon.
Masuda K, Ikeda Y, Matsuura T, Kawakatsu T, Tao R, Kubo Y, Ushijima K, Henry IM, Akagi T 		Nature Plants 2022
Lipoprotein Lipase Overexpression in Skeletal Muscle Attenuates Weight Regain by Potentiating Energy Expenditure
DM Presby, MC Rudolph, VD Sherk, MR Jackman, RM Foright, KL Jones, JA Houck, GC Johnson, JA Higgins, PD Neufer, RH Eckel, PS MacLean 		Diabetes 2021
Liraglutide Increases the Catabolism of Apolipoprotein B100–Containing Lipoproteins in Patients With Type 2 Diabetes and Reduces Proprotein Convertase Subtilisin/Kexin Type 9 Expression
B Vergès, L Duvillard, JP de Barros, B Bouillet, S Baillot-Rudoni, A Rouland, JM Petit, P Degrace, L Demizieux 		Diabetes care 2021
Sitagliptin Improves Plasma Apolipoprotein Profile in Type 2 Diabetes: A Randomized Clinical Trial of Sitagliptin Effect on Lipid and Glucose Metabolism (SLIM) Study
K Tanimura-Inagaki, M Nagao, T Harada, H Sugihara, S Moritani, J Sasaki, S Kono, S Oikawa 		Diabetes Research and Clinical Practice 2020
Duration of the flaxseed diet promotes deposition of n-3 fatty acids in the meat and skin of Peking ducks
MS Shahid, Y Wu, Z Xiao, T Raza, X Dong, J Yuan 		Food & Nutrition Research 2019
Effect of an intensive lifestyle intervention on the prevalence of metabolic syndrome and its components among overweight and obese adults
M Guzmán, E Zbella, SS Alvarez, JL Nguyen, E Imperial, FJ Troncale, C Holub, AK Mallhi, S VanWyk 		Journal of Public Health 2019
Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying
D Sato, K Morino, F Nakagawa, K Murata, O Sekine, F Beppu, N Gotoh, S Ugi, H Maegawa 		International journal of molecular sciences 2017
High adipose LPL activity and adipocyte hypertrophy reduce visceral fat and metabolic risk in obese, older women: Adipocyte Hypertrophy and Metabolism
MC Serra, AS Ryan, JD Sorkin, KH Favor, AP Goldberg 		Obesity 2015
Beginning to Understand High-Density Lipoproteins
CG Santos-Gallego, JJ Badimon, RS Rosenson 		Endocrinology and metabolism clinics of North America 2014
Partially purified Peucedanum japonicum Thunb extracts exert anti-obesity effects in vitro
RN Nugara, M Inafuku, H Iwasaki, H Oku 		Nutrition 2014
Adipose Tissue Changes in Obesity and the Impact on Metabolic Function
S Sam, T Mazzone 		Translational Research 2014
Role of HDL in Those with Diabetes
CG Santos-Gallego, RS Rosenson 		Current Cardiology Reports 2014
Impact of Gastrectomy on High-Density Lipoprotein Cholesterol Elevation in Nonobese Patients During a 10-Year Follow-up
S Tsuji, A Nohara, Y Hayashi, I Yoshida, R Oka, T Moriuchi, T Hagishita, S Miyamoto, A Suzuki, T Okada, M Yamagishi 		Journal of Atherosclerosis and Thrombosis 2014
Role of HDL in those with diabetes
Carlos G Santos-Gallego, Robert S Rosenson 		Current Cardiology Reports 2014
Papel del tejido adiposo blanco en las complicaciones vasculares asociadas a la obesidad
A Gómez-Hernández, L Perdomo, Ó Escribano, M Benito 		Clínica e Investigación en Arteriosclerosis 2013
Relationship Among Serum Lipid levels, Obesity and Blood Pressure in Health Examined Adult Women
SK Park, YC Cho 		Journal of the Korea Academia-Industrial cooperation Society 2013
THE EFFECT OF HEPATIC LIPASE ON CORONARY ARTERY DISEASE IN HUMANS IS INFLUENCED BY THE UNDERLYING LIPOPROTEIN PHENOTYPE
JD Brunzell, A Zambon, SS Deeb 		Biochimica et Biophysica Acta 2011
The beneficial effects of HDL-C on atherosclerosis: rationale and clinical results
CG Santos-Gallego, F Torres, JJ Badimón 		Clinical Lipidology 2011
Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight
DH Kim, SC Woods, RJ Seeley 		Diabetes 2010
High-Density Lipoprotein and Coronary Heart Disease
P Natarajan, KK Ray, CP Cannon 		Journal of the American College of Cardiology 2010
Associations of Energy Intake and Type 2 Diabetes with Hypertryglyceridemia in Older Adults Living in the Mediterranean Islands: The Medis Study
S Tyrovolas, G Pounis, A Zeimbekis, M Antonopoulou, V Bountziouka, E Gotsis, G Metallinos, A Polystipioti, E Polychronopoulos, C Lionis, DB Panagiotakos 		Journal of Nutrition For the Elderly 2010
Vitamins & Hormones
KJ Hare, FK Knop 		Vitamins & Hormones 2010
Impact of Walking on Adipose Tissue Lipoprotein Lipase Activity and Expression in Pre- and Postmenopausal Women
S Tessier, É Riesco, M Lacaille, F Pérusse, J Weisnagel, J Doré, P Mauriège 		Obesity facts 2010
Postabsorptive VLDL-TG Fatty Acid Storage in Adipose Tissue in Lean and Obese Women
B Nellemann, LC Gormsen, JS Christiansen, MD Jensen, S Nielsen 		Obesity 2009
Ghrelin and Apolipoprotein AIV Levels Show Opposite Trends to Leptin Levels During Weight Loss in Morbidly Obese Patients
E Pardina, MD López-Tejero, R Llamas, R Catalán, R Galard, H Allende, V Vargas, A Lecube, JM Fort, JA Baena-Fustegueras, J Peinado-Onsurbe 		Obesity Surgery 2009
Enhanced cortisol production rates, free cortisol, and 11β-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss
JQ Purnell, SE Kahn, MH Samuels, D Brandon, DL Loriaux, JD Brunzell 		American journal of physiology. Endocrinology and metabolism 2009
Lipoprotein lipase: from gene to obesity
H Wang, RH Eckel 		American journal of physiology. Endocrinology and metabolism 2009
Effect of Obesity on High-density Lipoprotein Metabolism**
S Rashid, J Genest 		Obesity 2007
Obesity
CY Chen, J Blumberg 		Obesity 2007
Obesity in Youth: Implications for the Advanced Practice Nurse in Primary Care
D Berry, P Galasso, G Melkus, M Grey 		Journal of the American Academy of Nurse Practitioners 2004
Diabetes, lipids, and adipocyte secretagogues
M Faraj, HL Lu, K Cianflone 		Biochemistry and Cell Biology 2004
Frontiers in Cardiovascular Health
NS Dhalla, A Chockalingam, HI Berkowitz, PK Singal 		2003
TNFα expression of subcutaneous adipose tissue in obese and morbid obese females: relationship to adipocyte LPL activity and leptin synthesis
M Bulló, P García-Lorda, J Peinado-Onsurbe, M Hernández, DD Castillo, JM Argilés, J Salas-Salvadó 		International Journal of Obesity 2002
Hormone sensitive lipase expression and adipose tissue metabolism show gender difference in obese subjects after weight loss
M Kolehmainen, H Vidal, JJ Ohisalo, E Pirinen, E Alhava, MI Uusitupa 		International Journal of Obesity 2002
Enhanced dietary fat clearance in postobese women
M Faraj, P Jones, AD Sniderman, K Cianflone 		Journal of lipid research 2001
Postprandial lipemia: effects of exercise and restriction of energy intake compared
JM Gill, AE Hardman 		The American journal of clinical nutrition 2000
Impact of body weight and weight loss on cardiovascular risk factors
KD Hecker, PM Kris-Etherton, G Zhao, S Coval, SS Jeor 		Current Atherosclerosis Reports 1999
From Preadipocyte to Adipocyte: Differentiation-Directed Signals of Insulin from the Cell Surface to the Nucleus
A Sorisky 		Critical Reviews in Clinical Laboratory Sciences 1999
Effects of hypocaloric dietary treatment enriched in oleic acid on LDL and HDL subclass distribution in mildly obese women
A Zambon, G Sartore, D Passera, F Francini-Pesenti, A Bassi, C Basso, S Zambon, E Manzato, G Crepaldi 		Journal of Internal Medicine 1999
Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase
PH Weinstock, S Levak-Frank, LC Hudgins, H Radner, JM Friedman, R Zechner, JL Breslow 		Proceedings of the National Academy of Sciences 1997
Deviations from maximum weight predict high-density lipoprotein cholesterol levels in runners: the National Runners' Health Study
PT Williams 		International Journal of Obesity 1997
Deviations from maximum weight predict high-density lipoprotein cholesterol levels in runners: the National Runners’ Health Study
PT Williams 		International Journal of Obesity 1997
Potential Role of TNFα and Lipoprotein Lipase as Candidate Genes for Obesity
PA Kern 		The Journal of nutrition 1997
Regulation of Body Adiposity and the Problem of Obesity
MW Schwartz, JD Brunzell 		Arteriosclerosis, thrombosis, and vascular biology 1997
FAT CELLS
TG Ramsay 		Endocrinology & Metabolism Clinics of North America 1996
Decrease in fat oxidation following a meal in weight-reduced individuals: A possible mechanism for weight recidivism
DL Ballor, JR Harvey-Berino, PA Ades, J Cryan, J Calles-Escandon 		Metabolism 1996
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
PA Kern, M Saghizadeh, JM Ong, RJ Bosch, R Deem, RB Simsolo 		Journal of Clinical Investigation 1995
Sustained weight reduction in moderately obese women results in decreased activity of skeletal muscle lipoprotein lipase
RH Eckel, TJ Yost, DR Jensen 		European Journal of Clinical Investigation 1995
Proopiomelanocorticotropin (POMC) peptides and lipoprotein lipase activity in vitro
P Eichhorn, P Schwandt, WO Richter 		Peptides 1995
Short day-induced depletion of lipid stores is fat pad- and gender-specific in Siberian hamsters
TJ Bartness 		Physiology & Behavior 1995
Long-Term Weight Cycling in Female Wistar Rats: Effects on Metabolism
H Lu, A Buiso, V Uhley, KL Jen 		Obesity research 1995
A Role for Testosterone in the Maintenance of Seasonally Appropriate Body Mass but not in Lipectomy-Induced Body Fat Compensation in Siberian Hamsters
MM Mauer, TJ Bartness 		Obesity research 1995
Alteration of lipid profiles in plasma of transgenic mice expressing human lipoprotein lipase
MS Liu, FR Jirik, RC LeBoeuf, H Henderson, LW Castellani, AJ Lusis, Y Ma, IJ Forsythe, H Zhang, E Kirk 		The Journal of biological chemistry 1994
The regulation of adipose tissue and muscle lipoprotein lipase in runners by detraining
RB Simsolo, JM Ong, PA Kern 		Journal of Clinical Investigation 1993
Lipoprotein lipase gene expression: Physiological regulators at the transcriptional and post-transcriptional level
S Enerbäck, JM Gimble 		Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1993
Relative effects of weight loss and dietary fat modification on serum lipid levels in the dietary treatment of obesity
R Leenen, K van der Kooy, S Meyboom, JC Seidell, P Deurenberg, JA Weststrate 		Journal of lipid research 1993
Effects of weight-loss by exercise and by diet on apolipoproteins A-I and A-II and the particle-size distribution of high-density lipoproteins in men
PT Williams, RM Krauss, KM Vranizan, JJ Albers, PD Wood 		Metabolism: clinical and experimental 1992
The problem of obesity: Fundamental concepts of energy metabolism gone awry
JG Dausch 		Critical Reviews in Food Science and Nutrition 1992
Bulimia und Anorexia nervosa
C Jacobi, T Paul 		1991
Obesity A Biobehavioral Point of View
M Katahn, MR Mcminn 		Annals of the New York Academy of Sciences 1990
Weight set-point theory and the high-density lipoprotein concentrations of long-distance runners
PT Williams 		Metabolism: clinical and experimental 1990
Adverse effects of obesity on lipid and lipoprotein levels in insulin-dependent and non-insulin-dependent diabetes
M Laakso, K Pyörälä 		Metabolism 1990
The Effects of Weight Loss on the Activity and Expression of Adipose-Tissue Lipoprotein Lipase in Very Obese Humans
PA Kern, JM Ong, B Saffari, J Carty 		New England Journal of Medicine 1990
Changes in lipoprotein subfractions during diet-induced and exercise-induced weight loss in moderately overweight men
PT Williams, RM Krauss, KM Vranizan, PD Wood 		Circulation 1990
Effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein, and messenger RNA levels in human adipose tissue
JM Ong, PA Kern 		Journal of Clinical Investigation 1989
Familial lipoprotein lipase-activity deficiency: Study of total body fatness and subcutaneous fat tissue distribution
LD Brun, C Gagné, P Julien, A Tremblay, S Moorjani, C Bouchard, PJ Lupien 		Metabolism 1989
Nutritional Management of Plasma Lipid Disorders
S Margolis, AS Dobs 		Journal of the American College of Nutrition 1989
The Fat Cell
J Hirsch, SK Fried, NK Edens, RL Leibel 		Medical Clinics of North America 1989
Exercise, lipoproteins, and coronary artery disease
RM Krauss 		Circulation 1989
Factors associated with high density lipoprotein cholesterol in a population with high high density lipoprotein cholesterol levels
K Steyn, J Fourie, AJ Benadé, JE Rossouw, ML Langenhoven, G Joubert, DO Chalton 		Arteriosclerosis (Dallas, Tex.) 1989
Localization of lipoprotein lipase mRNA in selected rat tissues
IJ Goldberg, DR Soprano, ML Wyatt, TM Vanni, TG Kirchgessner, MC Schotz 		Journal of lipid research 1989
Elevated adipose tissue lipoprotein lipase activity in craniopharyngioma patients
R Sorva, MR Taskinen, T Kuusi, J Perheentupa, EA Nikkilä 		Metabolism 1988
Weight loss leads to a marked decrease in nonresting energy expenditure in ambulatory human subjects
DS Weigle, KJ Sande, PH Iverius, ER Monsen, JD Brunzell 		Metabolism 1988
Biological Barriers in Behavioral Medicine
W Linden 		1988
Benefits of Aerobic Conditioning and Diet for Overweight Adults:
RD Hagan 		Sports Medicine 1988
Weight reduction increases adipose tissue lipoprotein lipase responsiveness in obese women
RH Eckel, TJ Yost 		Journal of Clinical Investigation 1987
Diet composition and lipoprotein lipase (EC 3.1.1.34) activity in human obesity
LA Smolin, MB Grosvenor, DJ Handelsman, JA Brasel 		British Journal of Nutrition 1987
Regional variation in high-density lipoprotein binding to human adipocyte plasma membranes of massively obese subjects
AM Salter, BE FONGx, J Jimenez, L Rotstein, A Angel 		European Journal of Clinical Investigation 1987
Early and late effects of weight loss on lipoprotein metabolism in severe obesity
S Rössner, H Björvell 		Atherosclerosis 1987
Mechanisms Associating Body Fat Distribution to Glucose Intolerance and Diabetes Mellitus: Window with a View
AH Kissebah, AN Peiris, DJ Evans 		Acta Medica Scandinavica 1987
Basal and postprandial lipoprotein lipase activity in adipose tissue during caloric restriction and refeeding
MR Taskinen, EA Nikkilä 		Metabolism 1987
Obesity: Pathophysiology and practical management
DL Elliot, L Goldberg, DE Girard 		Journal of General Internal Medicine 1987
Aldosterone and the mobilization of energy
L Devenport, G Manes, T Thomas, S Mena, D Kem, A Knehans 		Appetite 1987
Adipose Tissue of Morbidly Obese Patients: Clinical Implications of Distribution, Morphology, and Metabolism
SK Fried, JG Kral 		Gastroenterology Clinics of North America 1987
The Effect of Exercise on Lipid Metabolism in Men and Women:
L Goldberg, DL Elliot 		Sports Medicine 1987
The unique merits of a low-fat diet for weight control
MF McCarty 		Medical Hypotheses 1986
Characterization of rat adipose tissue lipoprotein lipase using a monospecific antibody
NA Vydelingum, F AlQuadan, AH Kissebah, J Etienne 		Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1986
Regulation of lipoprotein lipase in primary cultures of isolated human adipocytes
PA Kern, S Marshall, RH Eckel 		Journal of Clinical Investigation 1985
Changes in Lipoprotein Metabolism during a Supplemented Fast and an Ensuing Vegetarian Diet Period
H Lithell, Å Bruce, IB Gustafsson, NJ Höglund, B Karlström, K Ljunghall, K Sjölin, I Werner, B Vessby 		Upsala Journal of Medical Sciences 1985
Adipocyte precursor clones vary in capacity for differentiation
P Djian, DA Roncari, CH Hollenberg 		Metabolism 1985
New Perspectives in Adipose Tissue
A Cryer 		New Perspectives in Adipose Tissue 1985
Chylomicronemia induced by cimetidine
PH Iverius, JD Brunzell 		Gastroenterology 1985
Adipose tissue lipoprotein lipase activity in rats maintained at a reduced body weight
JM Hamilton, HW Heller, GN Wade 		Physiology & Behavior 1984
Weight Gain after Cessation of Cigarette Smoking: A Possible Role for Adipose-Tissue Lipoprotein Lipase
RM Carney, AP Goldberg 		New England Journal of Medicine 1984
Genetic Factors in Nutrition
NW Solomons 		Genetic Factors in Nutrition 1984
Effect of weight loss in moderate obesity on plasma lipoprotein and apolipoprotein levels and on high density lipoprotein composition
J Zimmerman, NA Kaufmann, M Fainaru, S Eisenberg, Y Oschry, Y Friedlander, Y Stein 		Arteriosclerosis (Dallas, Tex.) 1984
The psychology and physiology of obesity: Implications for screening and treatment
KD Brownell 		Journal of the American Dietetic Association 1984
Modern Concepts Of Obesity
JR Vasselli, MP Cleary, TB Itallie 		Nutrition Reviews 1983
Does weight loss cause the exercise-induced increase in plasma high density lipoproteins?
PT Williams, PD Wood, RM Krauss, WL Haskell, KM Vranizan, SN Blair, R Terry, JW Farquhar 		Atherosclerosis 1983
Influence of weight reduction on plasma lipoproteins in obese patients
RN Wolf, SM Grundy 		Arteriosclerosis (Dallas, Tex.) 1983
Familial chylomicronemia due to a circulating inhibitor of lipoprotein lipase activity
JD Brunzell, NE Miller, P Alaupovic, RJ Hilaire, CS Wang, DL Sarson, SR Bloom, B Lewis 		Journal of lipid research 1983
Lipoprotein lipase secretion by human monocyte-derived macrophages
A Chait, PH Iverius, JD Brunzell 		Journal of Clinical Investigation 1982
Characterization of lipase activities in obese Pima indians. Decreases with weight reduction
JS Reitman, FC Kosmakos, BV Howard, MR Taskinen, T Kuusi, EA Nikkila 		Journal of Clinical Investigation 1982
The Dietary Treatment of Hyperlipidemia: Rationale, Technique and Efficacy
WE Connor, SL Connor 		Medical Clinics of North America 1982
Regulation of High Density Lipoprotein Levels
RM Krauss 		Medical Clinics of North America 1982
The effects of age, body wight and family relationships on plasma lipoproteins and lipids in men, women and children of randomly selected families
SL Connor, WE Connor, G Sexton, L Calvin, S Bacon 		Circulation 1982
Changes in grafts and coronary arteries after saphenous vein aortocoronary bypass surgery: results at repeat angiography
MG Bourassa, L Campeau, J Lespérance, CM Grondin 		Circulation 1982

Advertisement