Citations to this article

The Adrenal Receptor for Angiotensin II is Altered in Essential Hypertension
Gordon H. Williams, … , Stephen L. Swartz, Robert G. Dluhy
Gordon H. Williams, … , Stephen L. Swartz, Robert G. Dluhy
Published March 1, 1979
Citation Information: J Clin Invest. 1979;63(3):419-427. https://doi.org/10.1172/JCI109318.
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Research Article

The Adrenal Receptor for Angiotensin II is Altered in Essential Hypertension

Abstract

To determine the mechanism underlying altered adrenal responsiveness in patients with essential hypertension, the renin-angiotensin-aldosterone axis was assessed in normotensive and hypertensive subjects using three pharmacological probes: SQ 20881, a converting enzyme inhibitor; saralasin, a competitive angiotensin antagonist with prominent agonist properties; and angiotensin itself. All subjects were studied while supine and in balance on a 10 meq Na/100 meq K intake. The decrement in plasma aldosterone with SQ 20881 in 26 hypertensive subjects (15±3 ng/dl) was normal (13±4 ng/dl), suggesting that the altered adrenal responsiveness in hypertensives is not because of a change in a postreceptor event or in the relative contribution of angiotensin to the control of aldosterone secretion.

Authors

Gordon H. Williams, Norman K. Hollenberg, Thomas J. Moore, Stephen L. Swartz, Robert G. Dluhy

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Total citations by year

Year: 1993 1991 1983 1982 1981 1979 Total
Citations: 1 1 2 4 2 1 11
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Citations to this article (11)

Title and authors Publication Year
Effects of losartan on blood pressure, plasma renin activity, and angiotensin II in volunteers
MR Goldberg, W Tanaka, A Barchowsky, TE Bradstreet, J McCrea, MW Lo, EJ McWilliams, TD Bjornsson 		Hypertension 1993
Feasibility of outpatient electrolyte balance studies
ML McCullough, JF Swain, C Malarick, TJ Moore 		Journal of the American College of Nutrition 1991
Achievements in hypertension: A 25 year overview
ED Frohlich 		Journal of the American College of Cardiology 1983
Nervous disorders of renal function
AD Baines 		Clinical Biochemistry 1983
Decreased adrenal responsiveness to angiotensin II: a defect present in spontaneously hypertensive rats. A possible model of human essential hypertension
GH Williams, LM Braley, A Menachery 		Journal of Clinical Investigation 1982
Rapid increase of mineralocorticoids after furosemide in low-renin essential hypertension: Evidence for 18-hydroxycorticosterone to be a better marker than aldosterone
H Witzgall, G Thayil, PC Weber 		Klinische Wochenschrift 1982
Parallel adrenal and renal abnormalities in young patients with essential hypertension
GH Williams, ML Tuck, JM Sullivan, RG Dluhy, NK Hollenberg 		The American Journal of Medicine 1982
Dopaminergic modulation of pressor and hormonal responses in essential hypertension
JR Sowers, MS Golub, ME Berger, LA Whitfield 		Hypertension 1982
Response of aldosterone and 18-hydroxycorticosterone to angiotensin II in normal subjects and patients with essential hypertension, Conn's syndrome, and nontumorous hyperaldosteronism
R Fraser, C Beretta-Piccoli, JJ Brown, AM Cumming, AF Lever, PA Mason, JJ Morton, JI Robertson 		Hypertension 1981
Contemporary Nephrology
S Klahr, SG Massry 		1981
Abnormal Adrenal Responsiveness and Angiotensin II Dependency in High Renin Essential Hypertension
RG Dluhy, SZ Bavli, FK Leung, HS Solomon, TJ Moore, NK Hollenberg, GH Williams 		Journal of Clinical Investigation 1979

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