Citations to this article

Functional Profile of the Isolated Uremic Nephron: ROLE OF COMPENSATORY HYPERTROPHY IN THE CONTROL OF FLUID REABSORPTION BY THE PROXIMAL STRAIGHT TUBULE
Leon G. Fine, … , Jacques J. Bourgoignie, Neal S. Bricker
Leon G. Fine, … , Jacques J. Bourgoignie, Neal S. Bricker
Published June 1, 1978
Citation Information: J Clin Invest. 1978;61(6):1508-1518. https://doi.org/10.1172/JCI109071.
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Functional Profile of the Isolated Uremic Nephron: ROLE OF COMPENSATORY HYPERTROPHY IN THE CONTROL OF FLUID REABSORPTION BY THE PROXIMAL STRAIGHT TUBULE

Abstract

An in vitro approach to the study of single nephron function in uremia has been employed in evaluating the control of fluid reabsorption by the renal superficial proximal straight tubule (PST). Isolated segments of PSTs from the remnant kidneys of uremic rabbits (stage III) were perfused in vitro and their rate of fluid reabsorption compared with normal PSTs and with PSTs derived from the remnant kidneys of nonuremic rabbits (stage II). All segments were exposed to a peritubular bathing medium of both normal and uremic rabbit serum thereby permitting a differentiation to be made between adaptations in function which are intrinsic to the tubular epithelium and those which are dependent upon a uremic milieu.

Authors

Leon G. Fine, Walter Trizna, Jacques J. Bourgoignie, Neal S. Bricker

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Citations to this article (41)

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S Hohmann, S Nielsen 		2000
Altered expression of Na transporters NHE-3, NaPi-II, Na-K-ATPase, BSC-1, and TSC in CRF rat kidneys
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TH Kwon, J Frøkiaer, MA Knepper, S Nielsen 		American journal of physiology. Renal physiology 1998
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Glomerular and tubular adaptive responses to acute nephron loss in the rat. Effect of prostaglandin synthesis inhibition
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Increased sodium transport by cortical collecting tubules from remnant kidneys
VM Vehaskari, KS Hering-Smith, S Klahr, LL Hamm 		Kidney International 1989
Nutritional Treatment of Chronic Renal Failure
S Giovannetti 		1989
Preventing the progression of human renal disease: Have rational therapeutic principles emerged?
LG Fine 		Kidney International 1988
Acute adaptative changes to unilateral nephrectomy in humans
A Argiles, G Mourad, N Basset, C Axelrud–Cavadore, J Haiech, C Mion, JC Cavadore, JG Demaille 		Kidney International 1987
Enhanced accumulation of injected inorganic mercury in renal outer medulla after unilateral nephrectomy
RK Zalups, JM Klotzbach, GL Diamond 		Toxicology and Applied Pharmacology 1987
Mercuric chloride-induced nephrotoxicity in the rat following unilateral nephrectomy and compensatory renal growth
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Load dependence of proximal tubular fluid and bicarbonate reabsorption in the remnant kidney of the Munich-Wistar rat
DA Maddox, JF Horn, FC Famiano, FJ Gennari 		Journal of Clinical Investigation 1986
The biology of renal hypertrophy
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Sodium-potassium ATPase activity mediates cyst formation in metanephric organ culture
ED Avner, WE Sweeney, DN Finegold, NP Piesco, D Ellis 		Kidney International 1985
Stimulation of Na+/H+ antiport is an early event in hypertrophy of renal proximal tubular cells
LG Fine, B Badie-Dezfooly, AG Lowe, A Hamzeh, J Wells, S Salehmoghaddam 		Proceedings of the National Academy of Sciences 1985
[3H]Ethylpropylamiloride, a ligand to analyze the properties of the Na+/H+ exchange system in the membranes of normal and hypertrophied kidneys
P Vigne, T Jean, P Barbry, C Frelin, LG Fine, M Lazdunski 		The Journal of biological chemistry 1985
Early enhancement of fluid transport in rabbit proximal straight tubules after loss of contralateral renal excretory function
K Tabei, DJ Levenson, BM Brenner 		Journal of Clinical Investigation 1983
Functional profile of the isolated uremic nephron: Intrinsic adaptation of phosphate transport in the rabbit proximal tubule
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Current Topics in Membranes and Transport
J Gliemann, WD Rees 		Current Topics in Membranes and Transport 1983
Introduction: Background and development of microperfusion technique
MB Burg 		Kidney International 1982
Studies of organic anion and cation transport in isolated segments of proximal tubules
JJ Grantham 		Kidney International 1982
Adaptation of renal tubule in uremia
LG Fine 		Kidney International 1982
Functional profile of the isolated uremic nephron. Evidence of proximal tubular "memory" in experimental renal disease
W Trizna, N Yanagawa, Y Bar-Khayim, B Houston, LG Fine 		Journal of Clinical Investigation 1981
Effect of prostaglandin inhibition on glomerular filtration rate in normal and uremic rabbits
MA Kirschenbaum, ER Serros 		Prostaglandins 1981
Functional profile of the isolated uremic nephron: potassium adaptation in the rabbit cortical collecting tubule
LG Fine, N Yanagawa, RG Schultze, M Tuck, W Trizna 		Journal of Clinical Investigation 1979
Functional Profile of the Isolated Uremic Nephron IMPAIRED WATER PERMEABILITY AND ADENYLATE CYCLASE RESPONSIVENESS OF THE CORTICAL COLLECTING TUBULE TO VASOPRESSIN
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