Functional Profile of the Isolated Uremic Nephron: ROLE OF COMPENSATORY HYPERTROPHY IN THE CONTROL OF FLUID REABSORPTION BY THE PROXIMAL STRAIGHT TUBULE

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Abstract

An in vitro approach to the study of single nephron function in uremia has been employed in evaluating the control of fluid reabsorption by the renal superficial proximal straight tubule (PST). Isolated segments of PSTs from the remnant kidneys of uremic rabbits (stage III) were perfused in vitro and their rate of fluid reabsorption compared with normal PSTs and with PSTs derived from the remnant kidneys of nonuremic rabbits (stage II). All segments were exposed to a peritubular bathing medium of both normal and uremic rabbit serum thereby permitting a differentiation to be made between adaptations in function which are intrinsic to the tubular epithelium and those which are dependent upon a uremic milieu.

Authors

Leon G. Fine, Walter Trizna, Jacques J. Bourgoignie, Neal S. Bricker