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Effect of Starvation on the Turnover and Metabolic Response to Leucine
Robert S. Sherwin
Robert S. Sherwin
Published June 1, 1978
Citation Information: J Clin Invest. 1978;61(6):1471-1481. https://doi.org/10.1172/JCI109067.
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Effect of Starvation on the Turnover and Metabolic Response to Leucine

Abstract

l-Leucine was administered as a primed continuous 3-4-h infusion in nonobese and obese subjects in the postabsorptive state and for 12 h in obese subjects after a 3-day and 4-wk fast. In nonobese and obese subjects studied in the post-absorptive state, the leucine infusion resulted in a 150-200% rise in plasma leucine above preinfusion levels, a small decrease in plasma glucose, and unchanged levels of plasma insulin and glucagon and blood ketones. Plasma isoleucine (60-70%) and valine (35-40%) declined to a greater extent than other amino acids (P < 0.001).

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Robert S. Sherwin

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Citations to this article (98)

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