Citations to this article

Gastric emptying and secretion in Zollinger-Ellison syndrome.
A Dubois, … , P V Eerdewegh, J D Gardner
A Dubois, … , P V Eerdewegh, J D Gardner
Published February 1, 1977
Citation Information: J Clin Invest. 1977;59(2):255-263. https://doi.org/10.1172/JCI108636.
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Research Article

Gastric emptying and secretion in Zollinger-Ellison syndrome.

Abstract

Gastric emptying and secretion, as well as intragastric volume and composition, were determined simultaneously in three patients with Zollinger-Ellison syndrome and in seven normal subjects. Gastric hypersecretion was observed in patients with Zollinger-Ellison syndrome and in normal subjects receiving pentagastrin. In contrast, the fraction of gastric contents emptied per minute (fractional rate of emptying) was increased in Zollinger-Ellison patients and unchanged or decreased in normal subjects receiving pentagastrin. The increased fractional rate of gastric emptying in patients with Zollinger-Ellison syndrome persisted despite abolition of gastric hypersecretion by metiamide. Thus, the increased fractional gastric emptying seen in patients with Zollinger-Ellison syndrome is not attributable to hypergastrinemia, or to gastric hypersecretion per se. Instead, it appears to be caused by an undefined nervous or humoral factor.

Authors

A Dubois, P V Eerdewegh, J D Gardner

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Citations to this article (70)

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