Citations to this article
Abstract
Gastric emptying and secretion, as well as intragastric volume and composition, were determined simultaneously in three patients with Zollinger-Ellison syndrome and in seven normal subjects. Gastric hypersecretion was observed in patients with Zollinger-Ellison syndrome and in normal subjects receiving pentagastrin. In contrast, the fraction of gastric contents emptied per minute (fractional rate of emptying) was increased in Zollinger-Ellison patients and unchanged or decreased in normal subjects receiving pentagastrin. The increased fractional rate of gastric emptying in patients with Zollinger-Ellison syndrome persisted despite abolition of gastric hypersecretion by metiamide. Thus, the increased fractional gastric emptying seen in patients with Zollinger-Ellison syndrome is not attributable to hypergastrinemia, or to gastric hypersecretion per se. Instead, it appears to be caused by an undefined nervous or humoral factor.
Authors
A Dubois, P V Eerdewegh, J D Gardner
Total citations by year
Citations to this article in year 1978 (2)
| Title and authors | Publication | Year |
|---|---|---|
|
Gastric retention in peptic ulcer disease: A reappraisal
A Dubois, SF Price, DO Castell |
The American Journal of Digestive Diseases | 1978 |
|
Report on the united states experience with cimetidine in zollinger-ellison syndrome and other hypersecretory states
DM Mccarthy |
Gastroenterology | 1978 |
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