Citations to this article

Immunoinhibition of ristocetin-induced platelet aggregation.
R L Nachman, … , E A Jaffe, B B Weksler
R L Nachman, … , E A Jaffe, B B Weksler
Published January 1, 1977
Citation Information: J Clin Invest. 1977;59(1):143-148. https://doi.org/10.1172/JCI108612.
View: Text | PDF
Research Article

Immunoinhibition of ristocetin-induced platelet aggregation.

Abstract

Human platelets washed and fixed in paraformaldehyde aggregate in the presence of the antibiotic ristocetin and normal plasma. This aggregation response is abolished after digestion of the fixed platelets with chymotrypsin. Antisera to fixed washed platelets were produced in rabbits and absorbed with chymotrypsin-treated, fixed washed platelets. Monovalent Fab fragments obtained from the isolated gamma-globulin fractions of the antisera blocked ristocetin-induced aggregation of fixed washed platelets in buffer and normal platelets in platelet-rich plasma. By double-antibody immunoprecipitation, it was shown that the antibody which blocked the ristocetin reaction interacted with a platelet membrane surface protein of mol wt 155,000. The results suggest that the glycoprotein I complex on the surface of the human platelet mediates ristocetin-induced von Willebrand factor-dependent platelet aggregation.

Authors

R L Nachman, E A Jaffe, B B Weksler

×

Total citations by year

Year: 2017 2013 2008 1998 1993 1991 1990 1989 1988 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 Total
Citations: 1 1 1 1 1 2 1 1 1 1 4 2 7 4 6 3 9 3 1 50
Citation information

Citations to this article (50)

Title and authors Publication Year
Men and Women Differ in the Biochemical Composition of Platelet-Rich Plasma
G Xiong, N Lingampalli, JC Koltsov, LL Leung, N Bhutani, WH Robinson, CR Chu 		The American journal of sports medicine 2017
Microfluidics and Coagulation Biology
TV Colace, GW Tormoen, OJ McCarty, SL Diamond 		Annual Review of Biomedical Engineering 2013
Decreased clearance of von Willebrand factor in a patient with type 2B von Willebrand disease following development of immune thrombocytopenia
ZJ Wang, N Onwuzurike, MU Callaghan, M Rajpurkar, M Chitlur, JM Lusher 		Pediatric Blood & Cancer 2008
Type 2M von Willebrand Disease: F606I and I662F Mutations in the Glycoprotein Ib Binding Domain Selectively Impair Ristocetin- but not Botrocetin-Mediated Binding of von Willebrand Factor to Platelets
CA Hillery, DJ Mancuso, JE Sadler, JW Ponder, MA Jozwiak, PA Christopherson, JC Gill, JP Scott, RR Montgomery 		Blood 1998
The assembly of the prothrombinase complex on adherent platelets
NA Swords, KG Mann 		Arteriosclerosis Thrombosis and Vascular Biology 1993
1 An approach to the management of infants with impaired haemostasis
M Andrew 		Baillière's Clinical Haematology 1991
von Willebrand factor
JE Sadler 		The Journal of biological chemistry 1991
The Clinical Significance of Platelet Membrane Glycoproteins
RP McEver 		Hematology/Oncology Clinics of North America 1990
The Effect of Diclofenac Sodium on Renal Function
AC Kinn, J Elbarouni, P Seideman, A Sollevi 		Scandinavian Journal of Urology and Nephrology 1989
Isolation and characterization of human platelet glycoprotein IX
GJ Roth, J Ozols, DJ Nugent, SA Williams 		Biochemical and Biophysical Research Communications 1988
Identification of the thrombin receptor on human platelets by chemical crosslinking
J Takamatsu, MK 3rd, HR Gralnick 		Journal of Clinical Investigation 1986
Structure and function of platelet membrane glycoproteins Ib and V. Effects of leukocyte elastase and other proteases on platelets response to von Willebrand factor and thrombin
AN WICKI, KJ CLEMETSON 		European Journal of Biochemistry 1985
Cloning and characterization of two cDNAs coding for human von Willebrand factor
JE Sadler, BB Shelton-Inloes, JM Sorace, JM Harlan, K Titani, EW Davie 		Proceedings of the National Academy of Sciences 1985
Advances in Hemostasis and Thrombosis
A Cajozzo, R Perricone, PD Marco, P Palazzolo 		1985
Platelet Membrane Glycoproteins
JN George, AT Nurden, DR Phillips 		1985
Preparation of monoclonal antibodies against glycoprotein IIIa of human platelets. Their effect on platelet aggregation
JA MELERO, J GONZALEZ-RODRIGUEZ 		European Journal of Biochemistry 1984
Neonatal Thrombocytopenia
M Andrew, J Kelton 		Clinics in Perinatology 1984
Monoclonal Antibodies against Platelet Membrane Glycoproteins. Characterization and Effect on Platelet Function
JL McGREGOR, J BROCHIER, F WILD, G FOLLEA, MC TRZECIAK, E JAMES, M DECHAVANNE, L McGREGOR, KJ CLEMETSON 		European Journal of Biochemistry 1983
Heparin-binding platelet proteins demonstrated by crossed affinity immunoelectrophoresis
GO Gogstad, NO Solum, MB Krutnes 		British Journal of Haematology 1983
Antibodies against platelet membrane glycoproteins
CS Jenkins, KJ Clemetson, EF Ali-Briggs 		British Journal of Haematology 1983
Potentiation of wheat germ agglutinin aggregation of platelets by von Willebrand protein and by a 116,000 molecular weight tryptic fragment
SE Martin, CW Francis, VJ Marder 		Thrombosis Research 1983
Antibodies against platelet membrane glycoproteins.: III. EFFECT ON THROMBIN- AND BOVINE VON WILLEBRAND FACTOR-INDUCED AGGREGATION
CS Jenkins, KJ Clemetson, EF Ali-Briggs 		British Journal of Haematology 1983
Antiplatelet Agents: Rationale and Results
JG Kelton 		Clinics in Haematology 1983
Purification of human platelet calcium-activated protease. Effect on platelet and endothelial function
N Yoshida, B Weksler, R Nachman 		The Journal of biological chemistry 1983
Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen
RL Nachman, LL Leung 		Journal of Clinical Investigation 1982
Thrombin-induced exposure and prostacyclin inhibition of the receptor for factor VIII/von Willebrand factor on human platelets
T Fujimoto, S Ohara, J Hawiger 		Journal of Clinical Investigation 1982
Association of membrane and cytoplasmic proteins with the cytoskeleton in blood platelets
A Rotman, J Heldman, S Linder 		Biochemistry 1982
The interaction of human coagulation factor Va with platelets
WH Kane, PW Majerus 		The Journal of biological chemistry 1982
Platelet Fc receptor. Increased expression in myeloproliferative disease
A Moore, RL Nachman 		Journal of Clinical Investigation 1981
Properties of human asialo-factor VIII. A ristocetin-independent platelet-aggregating agent
LD Marco, SS Shapiro 		Journal of Clinical Investigation 1981
Antibodies against Platelet Membrane Glycoproteins
EF Ali-Briggs, KJ Clemetson, CS Jenkins 		British Journal of Haematology 1981
Racial Differences in Ristocetin-induced Platelet Aggregation
GR Buchanan, CA Holtkamp, EN Levy 		British Journal of Haematology 1981
Thrombin-induced platelet membrane glycoprotein IIb and IIIa complex formation. An electron microscope study
MJ Polley, LL Leung, FY Clark, RL Nachman 		Journal of Experimental Medicine 1981
Isolation, purification, and partial characterization of platelet membrane glycoproteins IIb and IIIa
LL Leung, T Kinoshita, RL Nachman 		The Journal of biological chemistry 1981
Platelet activation and wheat germ agglutinin-binding
A Rotman, J Heldman 		FEBS Letters 1980
Parallel inhibition of ristocetin and polycation-induced platelet agglutination
TK Rosborough 		Thrombosis Research 1980
Serotonin binding sites of human blood platelets
BK Kim, M Steiner, MG Baldini 		Analytical Biochemistry 1980
Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets
KJ Kao, SV Pizzo, PA McKee 		Journal of Clinical Investigation 1979
Studies on the Mechanism of Ristocetin-induced Platelet Aggregation: Binding of Factor VIII to Platelets
MD Schneider-Trip, CS Jenkins, LH Kahlé, A Sturk, JW Cate 		British Journal of Haematology 1979
Further Studies on a Specific Platelet Antibody Found in Bernard-Soulier Syndrome and its Effects on Normal Platelet Function
G Tobelem, S Levy-Toledano, AT Nurden, L Degos, JP Caen, C Malmsten, H Kindahl 		British Journal of Haematology 1979
Thrombin Receptors of Human Platelets: Thrombin Binding and Antithrombin Properties of Glycoprotein I
P Ganguly, NL Gould 		British Journal of Haematology 1979
Platelet receptors for human Factor VIII/von Willebrand protein: functional correlation of receptor occupancy and ristocetin-induced platelet aggregation
KJ Kao, SV Pizzo, PA McKee 		Proceedings of the National Academy of Sciences 1979
Human megakaryocytes. I. Characterization of the membrane and cytoplasmic components of isolated marrow megakaryocytes
EM Rabellino, RL Nachman, N Williams, RJ Winchester, GD Ross 		Journal of Experimental Medicine 1979
Human platelet membrane receptor for bovine von Willebrand factor (platelet aggregating factor): an integral membrane glycoprotein
HA Cooper, KJ Clemetson, EF Lüscher 		Proceedings of the National Academy of Sciences 1979
Structural analysis of human platelet membrane glycoprotein I complex
RL Nachman, T Kinoshita, B Ferris 		Proceedings of the National Academy of Sciences 1979
Interaction of wheat germ agglutinin with rat platelets: Observations on stimulus-response coupling
P Ganguly, NG Fossett 		Thrombosis Research 1979
Interaction of Platelet Membrane Receptors with von Willebrand Factor, Ristocetin, and the Fc Region of Immunoglobulin G
A Moore, GD Ross, RL Nachman 		Journal of Clinical Investigation 1978
MEMBRANE GLYCOPROTEINS AND HUMAN PLATELET FUNCTION
AT Nurden, JP Caen 		British Journal of Haematology 1978
Wheat germ agglutinin affinity chromatography of human platelet membrane glycoproteins
RL Nachman, E Tarasov, BB Weksler, B Ferris 		Thrombosis Research 1978
Procoagulant Specificity of Factor VIII Inhibitor
HC Yang, M Kuzur 		British Journal of Haematology 1977

Advertisement