Citations to this article
Abstract
The effects of androstanediol and estradiol on prostatic growth were investigated in castrate dogs. Estrogens along resulted in no significant change in prostatic weight, whereas androstanediol produced growth comparable to that in uncastrated controls. Androstanediol plus estradiol resulted in an even more striking increase in prostate growth. Approximately half the animals receiving androstanediol alone and all of those receiving androstanediol plus estradiol fulfill the weight and histological criteria for prostatic hypertrophy in the dog. Since both these steroid hormones are presumed to be normal secretory products of the testis, it is possible that they are involved in the pathogenesis of prostatic hypertrophy in the dog.
Authors
P C Walsh, J D Wilson
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Citations to this article in year 2008 (5)
| Title and authors | Publication | Year |
|---|---|---|
|
Pre-receptor regulation of the androgen receptor
TM Penning, Y Jin, TL Rizner, DR Bauman |
Molecular and Cellular Endocrinology | 2008 |
|
5α-androstane-3α,17β-diol supports human prostate cancer cell survival and proliferation through androgen receptor-independent signaling pathways: Implication of androgen-independent prostate cancer progression
Q Yang, MA Titus, KM Fung, HK Lin |
Journal of Cellular Biochemistry | 2008 |
|
Immunolocalization of androgen and oestrogen receptors in the ventral lobe of rat (Rattus norvegicus) prostate after long-term treatment with ethanol and nicotine
WJ Fávaro, VH Cagnon |
International Journal of Andrology | 2008 |
|
3,3′-Diindolylmethane and Genistein Decrease the Adverse Effects of Estrogen in LNCaP and PC-3 Prostate Cancer Cells
S Smith, D Sepkovic, HL Bradlow, KJ Auborn |
The Journal of nutrition | 2008 |
|
Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling
WA Ricke, SJ McPherson, JJ Bianco, GR Cunha, Y Wang, GP Risbridger |
The FASEB Journal | 2008 |
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