Pressures and flows were measured in surface glomerular capillaries, efferent arterioles, and proximal tubules of 22 Wistar rats in the early autologous phase of nephrotoxic serum nephritis (NSN). Linear deposits of rabbit and rat IgG and C3 component of complement were demonstrated in glomerular capillary walls by immunofluorescence microscopy. Light microscopy revealed diffuse proliferative glomerulonephritis, and proteinuria was present. Although whole kidney and single nephron glomerular filtration rate (GFR) in NSN (0.8 plus or minus 0.04 SE2 ml/min and 2 plus or minus 2 nl/min, respectively) remained unchanged from values in 16 weight-matched NORMAL HYDROPENIC control rats (0.8 plus or minus 0.08 and 28 plus or minus 2), important alterations in glomerular dynamics were noted. Mean transcapillary hydraulic pressure difference (deltaP) averaged 41 plus or minus 1 mm Hg in NSN versus 32 plus or minus 1 in controls (P LESS THAN 0.005). Oncotic pressures at the afferent (piA) end of the glomerular capillary were similar in both groups ( 16 mm /g) but increased much less by the efferent end (piE) in NSN (to 29 plus or minus 1 mm Hg) than in controls (33 plus or minus 1, P less than 0.025). Hence, equality between deltaP and piE, denoting filtration pressure equilibrium, obtained in control but not in NSN rats. While glomerular plasma flow rate was slightly higher in NSN (88 plus or minus 8 nl/min) than in controls (76 plus or minus 6, P greater than 0.2), the failure to achieve filtration equilibrium in NSN rats was primarily the consequence of a marked fall in the glomerular capillary ultrafiltration coefficient, Kf, to a mean value of 0.03 nl/(s times mm Hg), considerably lower than that found recently for the normal rat, 0.08 nl/(s times mm Hg). Thus, despite extensive glomerular injury, evidenced morphologically and by the low Kf, GFR remained normal. This maintenance of GFR resulted primarily from increases in deltaP, which tended to increase the net driving force for filtration, and thereby compensate for the reduction in Kf.
D A Maddox, C M Bennett, W M Deen, R J Glassock, D Knutson, T M Daugharty, B M Brenner
Title and authors | Publication | Year |
---|---|---|
Beneficial effects of brief early life angiotensin-converting enzyme inhibition wane with time in sheep with solitary functioning kidney.
McArdle Z, Singh RR, Bielefeldt-Ohmann H, Moritz KM, Denton KM, Schreuder MF |
Clinical science (London, England : 1979) | 2023 |
Total Nephron Number and Single-Nephron Parameters in Patients with IgA Nephropathy
H Marumoto, N Tsuboi, V DAgati, T Sasaki, Y Okabayashi, K Haruhara, G Kanzaki, K Koike, A Shimizu, T Kawamura, A Rule, J Bertram, T Yokoo |
2021 | |
Total Nephron Number and Single-Nephron Parameters in Patients with IgA Nephropathy
H Marumoto, N Tsuboi, VD DAgati, T Sasaki, Y Okabayashi, K Haruhara, G Kanzaki, K Koike, A Shimizu, T Kawamura, AD Rule, JF Bertram, T Yokoo |
2021 | |
Role of ultrastructural determinants of glomerular permeability in ultrafiltration function loss
Andrea Remuzzi, Sara Conti, Bogdan Ene-Iordache, Susanna Tomasoni, Paola Rizzo, Ariela Benigni, Giuseppe Remuzzi |
JCI Insight | 2020 |
Edema in Renal Diseases – Current View on Pathogenesis
I Bobkova, N Chebotareva, L Kozlovskaya, E Shilov |
2016 | |
Glomerular Dynamics after Living Kidney Donation; a Longitudinal Study
Colin Lenihan, Stephan Busque, Geraldine Derby, Kristina Blouch, Bryan D. Myers, Jane Tan |
Journal of Clinical Investigation | 2015 |
RETRACTION: Angiotensin II and Canonical Transient Receptor Potential-6 Activation Stimulate Release of a Signal Transducer and Activator of Transcription 3–Activating Factor from Mouse Podocytes
M Abkhezr, SE Dryer |
Molecular pharmacology | 2014 |
Seldin and Giebisch's The Kidney
CJ Cooper, LD Dworkin, WL Henrich |
Seldin and Giebisch's The Kidney | 2013 |
Salt Sensitivity and Nondippers in Chronic Kidney Disease
M Fukuda, G Kimura |
Current Hypertension Reports | 2012 |
Glomerular function reserve and sodium sensitivity
G Kimura |
Clinical and Experimental Nephrology | 2005 |
Low birth weight, nephron number, and kidney disease
VA Luyckx, BM Brenner |
Kidney International | 2005 |
Nocturnal blood pressure is elevated with natriuresis and proteinuria as renal function deteriorates in nephropathy
M Fukuda, M Munemura, T Usami, N Nakao, O Takeuchi, Y Kamiya, A Yoshida, G Kimura |
Kidney International | 2004 |
Pirfenidone and candesartan ameliorate morphological damage in mild chronic anti-GBM nephritis in rats
S Leh, O Vaagnes, SB Margolin, BM Iversen, T Forslund |
Nephrology Dialysis Transplantation | 2004 |
Mechanisms of Glomerular Immune Injury: Effects of Antioxidant Treatment
SS Narsipur, OW Peterson, R Smith, TD Bigby, S Parthasarathy, FB Gabbai, CB Wilson, RC Blantz |
Journal of the American Society of Nephrology : JASN | 2003 |
Sodium Sensitivity of Blood Pressure Appearing Before Hypertension and Related to Histological Damage in Immunoglobulin A Nephropathy
Y Konishi, N Okada, M Okamura, T Morikawa, M Okumura, K Yoshioka, M Imanishi |
Hypertension | 2001 |
Relationship of renal histological damage to glomerular hypertension in patients with immunoglobulin A nephropathy
Y Konishi, M Imanishi, M Okamura, K Yoshioka, M Okumura, N Okada, S Tanaka, S Fujii, G Kimura |
Journal of Hypertension | 2000 |
Renal Hemodynamics in Rats with Cadmium-Induced Nephropathy
K Uriu, K Kaizu, N Komine, M Ikeda, YL Qie, O Hashimoto, A Matsuoka, S Eto |
Toxicology and Applied Pharmacology | 1998 |
Implications of the linear pressure–natriuresis relationship and importance of sodium sensitivity in hypertension
G Kimura, BM Brenner |
Journal of Hypertension | 1997 |
Sodium Restriction Shifts Circadian Rhythm of Blood Pressure From Nondipper to Dipper in Essential Hypertension
T Uzu, K Ishikawa, T Fujii, S Nakamura, T Inenaga, G Kimura |
Circulation | 1997 |
Cytoskeletal changes in podocytes associated with foot process effacement in Masugi nephritis
I Shirato, T Sakai, K Kimura, Y Tomino, W Kriz |
The American Journal of Pathology | 1996 |
The development of focal segmental glomerulosclerosis in Masugi nephritis is based on progressive podocyte damage
I Shirato, H Hosser, W Kriz, K Kimura, T Sakai, Y Tomino |
Virchows Archiv | 1996 |
Lipoxygenase Products in Normal and Diseased Glomeruli
KF Badr, FG Lakkis |
Annals of the New York Academy of Sciences | 1994 |
Nephrology
M Hatano |
Nephrology | 1991 |
Predominant functional roles for thromboxane A2 and prostaglandin E2 during late nephrotoxic serum glomerulonephritis in the rat
K Takahashi, GF Schreiner, K Yamashita, BW Christman, I Blair, KF Badr |
Journal of Clinical Investigation | 1990 |
Microvascular Disease and the Progression of IgA Nephropathy
R Katafuchi, E Vamvakas, K Neelakantappa, DS Baldwin, GR Gallo |
American Journal of Kidney Diseases | 1990 |
Outcome of the acute glomerular injury in proliferative lupus nephritis
A Chagnac, BA Kiberd, MC Fariñas, S Strober, RK Sibley, R Hoppe, BD Myers |
Journal of Clinical Investigation | 1989 |
Glomerulosclerosis: Are we any wiser?
AM Nahas |
Klinische Wochenschrift | 1989 |
Effect of indomethacin on glomerular permselectivity and hemodynamics in nephrotoxic serum nephritis
J Neugarten, A Kozin, K Cook |
Kidney International | 1989 |
Renal Eicosanoids
MJ Dunn, C Patrono, GA Cinotti |
1989 | |
Preservation of the glomerular capillary ultrafiltration coefficient during rat nephrotoxic serum nephritis by a specific leukotriene D4 receptor antagonist
KF Badr, GF Schreiner, M Wasserman, I Ichikawa |
Journal of Clinical Investigation | 1988 |
Mechanisms underlying transition from acute glomerular injury to late glomerular sclerosis in a rat model of nephrotic syndrome
S Anderson, JR Diamond, MJ Karnovsky, BM Brenner |
Journal of Clinical Investigation | 1988 |
Evaluation of the renal injury from gold salts and nonsteroidal anti-inflammatory drugs in patients with rheumatoid arthritis
N Giordano, E Frati, A Fioravanti, A Taddeo, G Morozzi, R Marcolongo |
Clinical Rheumatology | 1988 |
Ultrafiltration coefficients of glomeruli from human biopsies
WP Richardson, R Hassanein, RV Pinnick, VJ Savin |
Kidney International | 1988 |
Pathophysiology of Acute Glomerulonephritis
RJ Glassock |
Hospital Practice | 1988 |
The influence of concomitant experimental hypertension and glomerulonephritis
RC Blantz, F Gabbai, LC Gushwa, CB Wilson |
Kidney International | 1987 |
An evaluation of the development of experimental membranous nephropathy
FB Gabbai, LC Gushwa, CB Wilson, RC Blantz |
Kidney International | 1987 |
The Gordon Wilson lecture. Why kidneys fail: an unifying hypothesis
BM Brenner, S Anderson |
Transactions of the American Clinical and Climatological Association | 1987 |
Hypertension and Renal Diseases
DS Baldwin, J Neugarten |
American Journal of Kidney Diseases | 1987 |
Clinical Aspects of Glomerular Diseases
RJ Glassock |
American Journal of Kidney Diseases | 1987 |
Clinical Disorders of Membrane Transport Processes
TE Andreoli, JF Hoffman, DD Fanestil, SG Schultz |
1987 | |
Effect of colloid volume expansion on glomerular barrier size–selectivity in humans
O Shemesh, WM Deen, BM Brenner, E McNeely, BD Myers |
Kidney International | 1986 |
Genetic factors in focal segmental glomerulosclerosis
JJ Weening, JJ Beukers, J Grond, JD Elema |
Kidney International | 1986 |
Effects of nonsteroidal anti-inflammatory drugs on proteinuria
R Vriesendorp, AJ Donker, D Zeeuw, PE de Jong, GK van der Hem, JR Brentjens |
The American Journal of Medicine | 1986 |
Limitations of Creatinine in Quantifying the Severity of Cyclosporine-Induced Chronic Nephropathy
S Tomlanovich, H Golbetz, M Perlroth, E Stinson, BD Myers |
American Journal of Kidney Diseases | 1986 |
Factors Contributing to Progression of Renal Disease
C Baylis, RC Blantz |
The International Journal of Artificial Organs | 1986 |
Histamine modulates contraction and cyclic nucleotides in cultured rat mesangial cells. Differential effects mediated by histamine H1 and H2 receptors
JR Sedor, HE Abboud |
Journal of Clinical Investigation | 1985 |
Limitations of creatinine as a filtration marker in glomerulopathic patients
O Shemesh, H Golbetz, JP Kriss, BD Myers |
Kidney International | 1985 |
Nephrotoxic serum nephritis with hypertension: Amelioration by antihypertensive therapy
J Neugarten, B Kaminetsky, H Feiner, RG Schacht, DT Liu, DS Baldwin |
Kidney International | 1985 |
Role of prostaglandins and angiotensin II in experimental glomerulonephritis
K Kaizu, D Marsh, R Zipser, RJ Glassock |
Kidney International | 1985 |
The renal hemodynamic consequences of experimental glomerulonephritis
RJ Glassock, K Kaizu, T Sakai, R Zipser, D Marsh |
Transactions of the American Clinical and Climatological Association | 1985 |
Treatment of Hypertension in Renal Disease
DS Baldwin, J Neugarten |
American Journal of Kidney Diseases | 1985 |
Epidemic poststreptococcal glomerulonephritis
B Rodríguez-Iturbe |
Kidney International | 1984 |
Extracellular fluid expansion and autoregulation in nephrotoxic serum nephritis in rats
T Sakai, FH Harris, DJ Marsh, CM Bennett, RJ Glassock, C Martin, B Kayser, C Chung |
Kidney International | 1984 |
Renal Syndromes Associated with Nonsteroidal Antiinflammatory Drugs
DM Clive, JS Stoff |
New England Journal of Medicine | 1984 |
Proximal tubular bicarbonate reabsorption and PCO2 in chronic metabolic alkalosis in the rat
DA Maddox, FJ Gennari |
Journal of Clinical Investigation | 1983 |
Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. Effects on renal hemodynamics
EA Lianos, GA Andres, MJ Dunn |
Journal of Clinical Investigation | 1983 |
Amelioration of experimental glomerulonephritis by dietary protein restriction
J Neugarten, HD Feiner, RG Schacht, DS Baldwin |
Kidney International | 1983 |
Role of tubular obstruction in acute renal failure due to gentamicin
J Neugarten, HS Aynedjian, N Bank |
Kidney International | 1983 |
Intrarenal pressure and sodium excretion in hypertension of chronic glomerulonephritis in humans
Y Willassen, J Ofstad |
Hypertension | 1983 |
Glomerular ultrafiltration coefficient after ischemic renal injury in dogs
VJ Savin, RV Patak, G Marr, AS Hermreck, SM Ridge, K Lake |
Circulation research | 1983 |
Immune Mechanisms in Renal Disease
NB Cummings, AF Michael, CB Wilson |
1983 | |
Nephrology Forum
JJ Cohen, JT Harrington, JP Kassirer |
1983 | |
Mechanism of glomerulotubular balance in the setting of heterogeneous glomerular injury. Preservation of a close functional linkage between individual nephrons and surrounding microvasculature
I Ichikawa, JR Hoyer, MW Seiler, BM Brenner |
Journal of Clinical Investigation | 1982 |
Chronic glomerulonephritis: Nonimmunologic mechanisms of progressive glomerular damage
DS Baldwin |
Kidney International | 1982 |
Ultrafiltration coefficient and glomerular capillary resistance in a model of immune complex glomerulonephritis
VJ Savin, HB Lindsley, RB Nagle, R Cachia |
Kidney International | 1982 |
Aggravation of experimental glomerulonephritis by superimposed clip hypertension
J Neugarten, HD Feiner, RG Schacht, GR Gallo, DS Baldwin |
Kidney International | 1982 |
Glomerular function in advanced human diabetic nephropathy
JA Winetz, HV Golbetz, RJ Spencer, JA Lee, BD Myers |
Kidney International | 1982 |
Disorders of body fluids, sodium and potassium in chronic renal failure
WE Much, CS Wilcox |
The American Journal of Medicine | 1982 |
Shunt Nephritis Progressing to Chronic Renal Failure
M Schoeneman, B Bennett, I Greifer |
American Journal of Kidney Diseases | 1982 |
A network thermodynamic model of glomerular dynamics: Application in the rat
DE Oken, SR Thomas, DC Mikulecky |
Kidney International | 1981 |
Studies on the renin-aldosterone system in the acute nephritic syndrome
B Rodríguez-Iturbe, B Baggio, J Colina-Chourio, S Favaro, R García, F Sussana, L Castillo, A Borsatti |
Kidney International | 1981 |
Nephritogenic Antibody Mechanisms Involving Antigens within the Glomerulus
CB Wilson |
Immunological Reviews | 1981 |
Glomerular epithelial cell changes in early postischemic acute renal failure in rabbits and man
K Solez, LC Racusen, A Whelton |
The American Journal of Pathology | 1981 |
The Nature of the Glomerular Injury in Minimal Change and Focal Sclerosing Glomerulopathies
JA Winetz, CR Robertson, HV Golbetz, BJ Carrie, WR Salyer, BD Myers |
American Journal of Kidney Diseases | 1981 |
A review of transcapillary fluid and solute exchange in the renal glomerulus
CR Robertson |
Microvascular Research | 1980 |
The glomerulus, passive filter or regulatory organ?
RC Blantz |
Klinische Wochenschrift | 1980 |
Inulin: An inadequate marker of glomerular filtration rate in kidney donors and transplant recipients?
RW Rosenbaum, KA Hruska, C Anderson, AM Robson, E Slatopolsky, S Klahr |
Kidney International | 1979 |
A micropuncture study of renal sodium retention in nephrotic syndrome in rats: Evidence for increased resistance to tubular fluid flow
S Kuroda, HS Aynedjian, N Bank |
Kidney International | 1979 |
Glomerular albumin filtration: A comparison of micropuncture studies in the isolated perfused rat kidney with in vivo experimental conditions
H Stolte, HJ Schurek, JM Alt |
Kidney International | 1979 |
Effect of indomethacin on glomerular permeability in the nephrotic syndrome
RG Tiggeler, B Hulme, PG Wijdeveld |
Kidney International | 1979 |
Evidence for a parathyroid hormone-dependent influence of calcium on the glomerular ultrafiltration coefficient
HD Humes, I Ichikawa, JL Troy, BM Brenner |
Journal of Clinical Investigation | 1978 |
Renal sodium retention during volume expansion in experimental nephrotic syndrome
DB Bernard, EA Alexander, WG Couser, NG Levinsky |
Kidney International | 1978 |
Estimation of relative glomerular capillary surface area in normal and hypertrophic rat kidneys
DW Knutson, F Chieu, CM Bennett, RJ Glassock, BS Kayser |
Kidney International | 1978 |
Adaptation of glomerular forces and flows to renal injury
BM Brenner |
The Yale journal of biology and medicine | 1978 |
Physiology of Membrane Disorders
TE Andreoli, JF Hoffman, DD Fanestil |
1978 | |
Renal Pharmacology
M Martinez-Maldonado |
1978 | |
Plasma protein handling in the rat kidney: Micropuncture experiments in the acute heterologous phase of Anti-GBM-nephritis
RG Galaske, CA Baldamus, H Stolte |
Pflügers Archiv - European Journal of Physiology | 1978 |
Lipid metabolism in plasma, liver, and adipose tissue of rats with experimental chronic nephrotic syndrome
RJ Morin, WD Davidson, SJ Rorke, LS Guo |
Lipids | 1977 |
Single-nephron pressures, flows, and resistances in hypertensive kidneys with nephrosclerosis
S Azar, MA Johnson, B Hertel, L Tobian |
Kidney International | 1977 |
Poststreptococcal glomerulonephritis
DS Baldwin |
The American Journal of Medicine | 1977 |
Mechanics of Glomerular Ultrafiltration
HL Bleich, ES Boro, BM Brenner, HD Humes |
New England Journal of Medicine | 1977 |
Permselectivity of of the glomerular capillary wall. Studies of experimental glomerulonephritis in the rat using neutral dextran
RL Chang, WM Deen, CR Robertson, CM Bennett, RJ Glassock, BM Brenner, JL Troy, IF Ueki, B Rasmussen |
Journal of Clinical Investigation | 1976 |
Permselectivity of of the glomerular capillary wall. Studies of experimental glomerulonephritis in the rat using neutral dextran
RL Chang, WM Deen, CR Robertson, CM Bennett, RJ Glassock, BM Brenner, JL Troy, IF Ueki, B Rasmussen |
Journal of Clinical Investigation | 1976 |
Acute effects of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat
RC Blantz, CB Wilson |
Journal of Clinical Investigation | 1976 |
Filtration of protein in the anti-glomerular basement membrane nephritic rat: A micropuncture study
H Baeyer, JB van Liew, J Klassen, JW Boylan, N Manz, P Muir |
Kidney International | 1976 |
Acute effect of nephrotoxic serum on renal sodium transport in the dog
SF Wen, JP Wagnild |
Kidney International | 1976 |
Methods in Pharmacology
M Martinez-Maldonado, A Schwartz |
1976 | |
Permselectivity of the glomerular capillary wall to macromolecules. II. Experimental studies in rats using neutral dextran
RL Chang, IF Ueki, JL Troy, WM Deen, CR Robertson, BM Brenner |
Biophysical Journal | 1975 |
The permeability of glomerular capillaries of aminonuceoside nephrotic rats to graded dextrans
JP Caulfield, MG Farquhar |
Journal of Experimental Medicine | 1975 |
Permselectivity of the glomerular capillary wall to macromolecules. I. Theoretical considerations
RS Chang, CR Robertson, WM Deen, BM Brenner |
Biophysical Journal | 1975 |