The isolated in situ perfused rat pancreas was used to study glucose and catecholamine control of glucagon secretion, and to investigate the possible role of endogenous cyclic AMP as a mediator of this secretory process. When perfusate glucose was acutely dropped from 100 to 25 mg/100 ml, glucagon was released in a biphasic pattern with an early spike and a later plateau-like response. 300 mg/100 ml glucose suppressed glucagon secretion to near the detection limit of the radioimmunoassay (15 pg/ml). When perfusate glucose was dropped from 300 to 25 mg/100 ml, a delayed, relatively small peak occurred suggesting persisting alpha cell suppression by prior high glucose exposure. 2-Deoxy d-glucose stimulated glucagon secretion and inhibited insulin secretion.
Gordon C. Weir, Stephen D. Knowlton, Donald B. Martin
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American journal of physiology. Endocrinology and metabolism | 1999 |
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American journal of physiology. Endocrinology and metabolism | 1996 |
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K Ito, H Maruyama, H Hirose, K Kido, K Koyama, K Kataoka, T Saruta |
Metabolism | 1995 |
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Diabetologia | 1993 |
The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment
B Thorens, YJ Wu, JL Leahy, GC Weir |
Journal of Clinical Investigation | 1992 |
[Val12] HRAS downregulates GLUT2 in beta cells of transgenic mice without affecting glucose homeostasis
M Tal, YJ Wu, M Leiser, M Surana, H Lodish, N Fleischer, G Weir, S Efrat |
Proceedings of the National Academy of Sciences | 1992 |
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JE Nestler, MA McClanahan |
Baillière's Clinical Endocrinology and Metabolism | 1992 |
Intra-islet insulin permits glucose to directly suppress pancreatic A cell function
CJ Greenbaum, PJ Havel, GJ Taborsky, LJ Klaff |
Journal of Clinical Investigation | 1991 |
Beta-cell dysfunction in hyperglycaemic rat models: recovery of glucose-induced insulin secretion with lowering of the ambient glucose level
JL Leahy, GC Weir |
Diabetologia | 1991 |
Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy
JL Leahy, S Bonner-Weir, GC Weir |
Journal of Clinical Investigation | 1988 |
Inhibition of adenosine 3′,5′-cyclic monophosphate phosphodiesterase by colchicine: Implications for glucagon and corticosteroid secretion
R Ewart, M Bradford |
Life Sciences | 1988 |
Adrenergic control of the glucagon response to ammonia in the perfused rat pancreas
T Ichiba, A Tanaka, Y Ohta |
Diabetes Research and Clinical Practice | 1988 |
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H C Lee, K B Huh |
The Korean Journal of Internal Medicine | 1988 |
The Pathology of the Endocrine Pancreas in Diabetes
PJ Lefèbvre, DG Pipeleers |
1988 | |
Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
S Mojsov, GC Weir, JF Habener |
Journal of Clinical Investigation | 1987 |
Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions
JL Leahy, HE Cooper, DA Deal, GC Weir |
Journal of Clinical Investigation | 1986 |
Adrenergic modulation of pancreatic glucagon and insulin secretion in goats
O Shinnichi, O Yasushi, O Akira, S Yasuyuki, T Tsuneyuki |
Comparative Biochemistry and Physiology Part A: Physiology | 1986 |
Adrenergically mediated intrapancreatic control of the glucagon response to glucopenia in the isolated rat pancreas
A Hisatomi, H Maruyama, L Orci, M Vasko, RH Unger |
Journal of Clinical Investigation | 1985 |
Pancreatic islets of variable size - insulin secretion and glucose utilization
RM Colella, S Bonner-Weir, LP Braunstein, M Schwalke, GC Weir |
Life Sciences | 1985 |
Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
S Bonner-Weir, DF Trent, GC Weir |
Journal of Clinical Investigation | 1983 |
Glucagon II
PJ Lefebvre |
1983 | |
Role of glucose and insulin in the dynamic regulation of glucagon release by the perfused rat pancreas
V Leclercq-Meyer, J Marchand, WJ Malaisse |
Diabetologia | 1983 |
Dynamics of insulin and glucagon secretion by the isolated perfused cat pancreas
DL Curry, JG Morris, QR Rogers, JS Stern |
Comparative Biochemistry and Physiology Part A: Physiology | 1982 |
Acute hypoglycemia in man: Neural control of pancreatic islet cell function
RJ Corrall, BM Frier |
Metabolism | 1981 |
The biological activity of catfish pancreatic somatostatin
H Oyama, J Martin, K Sussman, GC Weir, A Permutt |
Regulatory Peptides | 1981 |
Limited B cell regeneration in a B cell deficient rat model: Studies with dexamethasone
S Bonner-Weir, DF Trent, CJ Zmachinski, ET Clore, GC Weir |
Metabolism | 1981 |
Metabolic effects of theophylline in preterm infants
G Srinivasan, RS Pildes, JB Jaspan, J Singh, H Shankar, TF Yeh, A Tiruvury |
The Journal of Pediatrics | 1981 |
Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor
AF Gazdar, WL Chick, HK Oie, HL Sims, DL King, GC Weir, V Lauris |
Proceedings of the National Academy of Sciences | 1980 |
Inhibition of glucagon and insulin secretion from the perfused rat pancreas by a B-cell-selective somatostatin analog
GC Weir, JA Schwarz, CJ Mathe |
Metabolism | 1980 |
Effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas
RN Honey, MB Fallon, GC Weir |
Metabolism | 1980 |
Insulin, glucagon, and somatostatin secretion from isolated perfused rat and chicken pancreas-duodenum
RN Honey, JA Schwarz, CJ Mathe, GC Weir |
American journal of physiology. Endocrinology and metabolism | 1980 |
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B Schlegel |
1980 | |
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V Grill, U Adamson, M Rundfeldt, S Andersson, E Cerasi |
Journal of Clinical Investigation | 1979 |
Interactions of ?-ketoisocaproate, glucose and arginine in the secretion of glucagon and insulin from the perfused rat pancreas
V Leclercq-Meyer, J Marchand, R Leclercq, WJ Malaisse |
Diabetologia | 1979 |
Effect of dihydroergocristine infusion on tolbutamide-induced insulin secretion in man
F Caviezel, M Poli, AM Girardi, G Pozza |
Experientia | 1979 |
Differential effect of isoproterenol on acute glucagon and insulin release in man
JP Palmer, J Halter, PL Werner |
Metabolism | 1979 |
Paradoxical short-term effects of cyproheptadine on insulin and glucagon release in the rat
GF Bryce, JH Jacoby |
European Journal of Pharmacology | 1979 |
Insulin stimulates somatostatin and inhibits glucagon secretion from the perfused chicken pancreas-duodenum
RN Honey, GC Weir |
Life Sciences | 1979 |
Effect of phentolamine on the somatostatin-induced inhibition of glucagon and insulin secretion
A Kaneto, H Kajinuma, T Kaneko, K Kosaka |
Metabolism | 1978 |
The effects of hexoprenaline, a β2-sympathomimetic drug, on maternal glucose, insulin, glucagon, and free fatty acid levels
J Lipshitz, AI Vinik |
American Journal of Obstetrics and Gynecology | 1978 |
Adaptation to potassium
P Silva, RS Brown, FH Epstein |
Kidney International | 1977 |
Defective blood glucose counter-regulation in diabetics is a selective form of autonomic neuropathy
LV Campbell, EW Kraegen, L Lazarus |
British medical journal | 1977 |
Investigations on isolated islets of langerhans in vitro
HJ Hahn, M Ziegler |
Biochimica et Biophysica Acta (BBA) - General Subjects | 1977 |
Electrophysiological evidence for the autoregulation of β-cell secretion by insulin
CS Page, FM Matschinsky, PE Lacy, S Conant |
Biochimica et Biophysica Acta (BBA) - General Subjects | 1977 |
Catecholamines and the regulation of hormone secretion
JB Young, L Landsberg |
Clinics in Endocrinology and Metabolism | 1977 |
Somatostatinoma: A Somatostatin-Containing Tumor of the Endocrine Pancreas
OP Ganda, GC Weir, JS Soeldner, MA Legg, WL Chick, YC Patel, AM Ebeid, KH Gabbay, S Reichlin |
New England Journal of Medicine | 1977 |
Glucagon response to hypoglycemia in sympathectomized man
JP Palmer, DP Henry, JW Benson, DG Johnson, JW Ensinck |
Journal of Clinical Investigation | 1976 |
The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man
AJ Garber, PE Cryer, JV Santiago, MW Haymond, AS Pagliara, DM Kipnis |
Journal of Clinical Investigation | 1976 |
Arginine-stimulated acute phase of insulin and glucagon secretion in diabetic subjects
JP Palmer, JW Benson, RM Walter, JW Ensinck |
Journal of Clinical Investigation | 1976 |
Stimulatory and inhibitory effects of cyclic AMP on pancreatic glucagon release from monolayer cultures and the controlling role of calcium
CB Wollheim, B Blondel, AE Renold, GW Sharp |
Diabetologia | 1976 |
The role of calcium in glucagon release, interactions between glucose and calcium
V Leclercq-Meyer, J Marchand, WJ Malaisse |
Diabetologia | 1976 |
Glucagon responses to hypoglycemia in adrenalectomized man
JW Ensinck, RM Walter, JP Palmer, RG Brodows, RG Campbell |
Metabolism | 1976 |
Diazepam: effects on glucagon and insulin release
B Petrack, AJ Czernik, W Itterly, J Ansell, H Chertock |
Biochemical and Biophysical Research Communications | 1976 |
INCREASED SOMATOSTATIN CONTENT OF ISLETS FROM STREPTOZOTOCIN-DIABETIC RATS
YC Patel, GC Weir |
Clinical Endocrinology | 1976 |
Glucagon secretion from the perfused rat pancreas following acute and chronic streptozotocin
GC Weir, RF Atkins, DB Martin |
Metabolism | 1976 |
High concentration of somatostatin immunoreactivity in chicken pancreas
GC Weir, PC Goltsos, EP Steinberg, YC Pate |
Diabetologia | 1976 |
Hormone secretion and glucose metabolism in islets of Langerhans of the isolated perfused pancreas from normal and streptozotocin diabetic rats
FM Matschinsky, AS Pagliara, BA Hover, CS Pace, JA Ferrendelli, A Williams |
The Journal of biological chemistry | 1976 |