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Citations to this article

Glucagon Secretion from the Perfused Rat Pancreas STUDIES WITH GLUCOSE AND CATECHOLAMINES
Gordon C. Weir, … , Stephen D. Knowlton, Donald B. Martin
Gordon C. Weir, … , Stephen D. Knowlton, Donald B. Martin
Published December 1, 1974
Citation Information: J Clin Invest. 1974;54(6):1403-1412. https://doi.org/10.1172/JCI107887.
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Glucagon Secretion from the Perfused Rat Pancreas STUDIES WITH GLUCOSE AND CATECHOLAMINES

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Abstract

The isolated in situ perfused rat pancreas was used to study glucose and catecholamine control of glucagon secretion, and to investigate the possible role of endogenous cyclic AMP as a mediator of this secretory process. When perfusate glucose was acutely dropped from 100 to 25 mg/100 ml, glucagon was released in a biphasic pattern with an early spike and a later plateau-like response. 300 mg/100 ml glucose suppressed glucagon secretion to near the detection limit of the radioimmunoassay (15 pg/ml). When perfusate glucose was dropped from 300 to 25 mg/100 ml, a delayed, relatively small peak occurred suggesting persisting alpha cell suppression by prior high glucose exposure. 2-Deoxy d-glucose stimulated glucagon secretion and inhibited insulin secretion.

Authors

Gordon C. Weir, Stephen D. Knowlton, Donald B. Martin

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Total citations by year

Year: 2020 2014 2011 2007 2005 2003 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1988 1987 1986 1985 1983 1982 1981 1980 1979 1978 1977 1976 Total
Citations: 1 1 1 1 1 1 1 1 1 3 1 4 1 1 2 3 2 5 1 2 2 3 1 4 5 6 2 6 11 74
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Citations to this article (74)

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