The Effect of 3′,5′-Adenosine Monophosphate on Granulocyte Adhesion

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Abstract

Human granulocyte adhesion to glass capillary tubes was tested in the presence of agents that increase intracellular levels of cyclic 3′,5′-adenosine monophosphate (cAMP). Adhesion was significantly reduced by 10-3-10-4 M dibutyryl cAMP, 10-4-10-6 M prostaglandin E1 (PGE1), 10-4-10-6 M histamine, or 10-3 M theophylline. Adhesion was not suppressed by 10-4 M theophylline unless it was combined with PGE1 or histamine. Eosinophil and basophil adhesion was especially sensitive to suppression by the above agents. These findings suggest that intracellular cAMP may play a role in regulation of adhesiveness of human basophils, eosinophils, and neutrophils.

Authors

Richard E. Bryant, Marilyn C. Sutgliffe