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Concise Publication Free access | 10.1172/JCI107868

The Effect of 3′,5′-Adenosine Monophosphate on Granulocyte Adhesion

Richard E. Bryant and Marilyn C. Sutgliffe

Department of Medicine, Veterans Administration Hospital, Nashville, Tennessee 25301

Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 25301

Find articles by Bryant, R. in: JCI | PubMed | Google Scholar

Department of Medicine, Veterans Administration Hospital, Nashville, Tennessee 25301

Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 25301

Find articles by Sutgliffe, M. in: JCI | PubMed | Google Scholar

Published November 1, 1974 - More info

Published in Volume 54, Issue 5 on November 1, 1974
J Clin Invest. 1974;54(5):1241–1244. https://doi.org/10.1172/JCI107868.
© 1974 The American Society for Clinical Investigation
Published November 1, 1974 - Version history
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Abstract

Human granulocyte adhesion to glass capillary tubes was tested in the presence of agents that increase intracellular levels of cyclic 3′,5′-adenosine monophosphate (cAMP). Adhesion was significantly reduced by 10-3-10-4 M dibutyryl cAMP, 10-4-10-6 M prostaglandin E1 (PGE1), 10-4-10-6 M histamine, or 10-3 M theophylline. Adhesion was not suppressed by 10-4 M theophylline unless it was combined with PGE1 or histamine. Eosinophil and basophil adhesion was especially sensitive to suppression by the above agents. These findings suggest that intracellular cAMP may play a role in regulation of adhesiveness of human basophils, eosinophils, and neutrophils.

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