A new radioimmunoassay for secretin was used to investigate (a) serum secretin responses to intraduodenally infused HCl and glucose, (b) the metabolic half-life and the volume of distribution of exogenous secretin and (c) the effect of endogenously released secretin on insulin secretion in 25 anesthetized dogs. Portal and femoral venous blood samples were taken simultaneously before, during, and after intraduodenal infusion of HCl (21 meq/30 min) and glucose (131 ml/30 min). Control experiments were performed with intraduodenal infusion of saline.
Guenther Boden, Noorjehan Essa, Oliver E. Owen, Frederick A. Reichle, Walter Saraga
Title and authors | Publication | Year |
---|---|---|
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine
IM Modvig, DB Andersen, KV Grunddal, RE Kuhre, C Martinussen, CB Christiansen, C Ørskov, P Larraufie, RG Kay, F Reimann, FM Gribble, B Hartmann, KN Bojsen-Møller, S Madsbad, NJ Albrechtsen, JJ Holst |
International Journal of Obesity | 2020 |
Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells
S MUSHA, S YOSHIDA, S MURAKAMI, R KOJIMA, M DEAI, N SASO, C MOGI, K SATO, F OKAJIMA, H TOMURA |
Journal of Reproduction and Development | 2020 |
Characterization of molecular mechanisms of extracellular acidification-induced intracellular Ca2+ increase in LβT2 cells
R Kojima, K Horiguchi, Y Mochimaru, S Musha, S Murakami, M Deai, C Mogi, K Sato, F Okajima, H Tomura |
Biochemical and Biophysical Research Communications | 2019 |
Comprehensive Physiology
SN Cheuvront, RW Kenefick |
Comprehensive Physiology | 2014 |
Annual Reports in Medicinal Chemistry
JJ Liu, TW Lee |
Annual Reports in Medicinal Chemistry Volume 46 | 2011 |
Central and Peripheral Administration of Secretin Inhibits Food Intake in Mice through the Activation of the Melanocortin System
CY Cheng, JY Chu, BK Chow |
Neuropsychopharmacology | 2010 |
Vitamins & Hormones
KJ Hare, FK Knop |
Vitamins & Hormones | 2010 |
Differential Activation of Adenylate Cyclase by Secretin and VIP Receptors in the Calf Pancreas
VL Meuth-Metzinger, V Philouze-Rome, L Metzinger, C Gespach, P Guilloteau |
Pancreas | 2005 |
Pancreatitis
RM Mitchell, MF Byrne, J Baillie |
The Lancet | 2003 |
D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells
M Kim, H J Cooke, N H Javed, H V Carey, F Christofi, H E Raybould |
Gastroenterology | 2001 |
III. Endocrine cell recognition of luminal nutrients
AM Buchan |
AJP Gastrointestinal and Liver Physiology | 1999 |
Beta-adrenergic stimulation contributes to incretin effect in conscious dogs
Z Chap, Y Okuda, J Pena, JB Field |
American journal of physiology. Endocrinology and metabolism | 1991 |
Insulin
P Cuatrecasas, S Jacobs |
Insulin | 1990 |
Dietary Starches and Sugars in Man: A Comparison
J Dobbing |
1989 | |
Inhibitory effects of pirenzepine on cholecystokinin and secretin stimulation on exocrine and endocrine rat pancreas
M Otsuki, Y Okabayashi, T Nakamura, M Fujii, T Oka, S Tani, S Baba |
Digestive Diseases and Sciences | 1987 |
Gastrointestinal peptides and insulin secretion
R Ebert, W Creutzfeldt |
Diabetes / Metabolism Reviews | 1987 |
Effects of intraduodenal nutrient infusion on insulin response to subsequent intravenous glucose in rats
T Ikeda, T Yoshida, M Honda, Y Ito, O Mokuda, M Tominaga, H Mashiba |
Metabolism | 1987 |
The effect of secretin on bile flow and bile acid and bilirubin excretion following relief of prolonged bile duct obstruction in the rat
J Kountouras, S McKavanagh, M Burmicky, BH Billing |
Journal of Hepatology | 1987 |
Human pepsinogens: A review of clinical and genetic aspects
B Westerveld, G Pals, J Defize, AE Eriksson, SG Meuwissen |
Journal of Gastroenterology and Hepatology | 1986 |
Secretin receptor activity in rat gastric glands. Binding studies, cAMP generation and pharmacology
C Gespach, D Bataille, N Vauclin, L Moroder, E Wünsch, G Rosselin |
Peptides | 1986 |
Effect of Graded Doses of Intraluminal H+, Prostaglandin E2, and Inhibition of Endogenous Prostaglandin Synthesis on Proximal Duodenal Bicarbonate Secretion in Unanesthetized Rat
JI Isenberg, B Smedfors, C Johansson |
Gastroenterology | 1985 |
Mechanism of Pancreatic Growth Induced by Pancreatico-Biliary Diversion in the Rat Inhibition by Proglumide, Benzotript, and Ranitidine
BM Miazza, Y Turberg, P Guillaume, W Hahne, JA Chayvialle, E Loizeau |
Scandinavian Journal of Gastroenterology | 1985 |
Effects of secretin and cholecystokinin-pancreocymin on water, electrolyte and glucose absorption in human jejunum
HC Dollinger, S Raptis, K Rommel, EF Pfeiffer |
Research in Experimental Medicine | 1982 |
Identification, characterization, and distribution of secretin immunoreactivity in rat and pig brain
TL O'Donohue, CG Charlton, RL Miller, G Boden, DM Jacobowitz |
Proceedings of the National Academy of Sciences | 1981 |
Plasma secretin concentrations and gastric pH in healthy subjects and patients with digestive diseases
JM Rominger, WY Chey, TM Chang |
Digestive Diseases and Sciences | 1981 |
Serum Group I Pepsinogens
HL Waldum, PG Burhol |
Scandinavian Journal of Gastroenterology | 1981 |
Effect of endogenous secretin on plasma glucagon after total pancreatectomy
T Sudo, T Suzuki, T Tobe, H Umemura, S Shiraha, T Kuyama |
World Journal of Surgery | 1981 |
Renal handling of secretin in dogs: Free and stop flow analyses
S Naruse |
Metabolism | 1980 |
Secretin
WH Hacki |
1980 | |
Radioimmunoassay of secretin: A critical review and current status
T Chang, WY Chey |
Digestive Diseases and Sciences | 1980 |
Release of Secretin-Plasma Levels Reproduced by Exogenous Infusion
DJ Byrnes, J Marjason, L Henderson, L Lazarus |
Australian and New Zealand Journal of Medicine | 1979 |
The role of cyclic AMP in canine secretin-stimulated bile flow
DL Kaminski, MJ Ruwart, YG Deshpande |
Journal of Surgical Research | 1979 |
7 Metabolic effects of gut hormones
JR Hayes, RW Henry |
Clinics in Endocrinology and Metabolism | 1979 |
Starvation-induced changes in secretin-like immunoreactivity of human plasma
JC Mason, RF Murphy, RW Henry, KD Buchanan |
Biochimica et Biophysica Acta (BBA) - General Subjects | 1979 |
Pancreatic and Gastric Somatostatin Release in Response to Intragastric and Intraduodenal Nutrients and HCl in the Dog
V Schusdziarra, V Harris, JM Conlon, A Arimura, R Unger |
Journal of Clinical Investigation | 1978 |
Pathophysiology of gastrin and secretin
KD Buchanan, JE Ardill |
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) | 1978 |
Methods of Hormone Radioimmunoassay
JA Prasad, CS Hollander |
Methods of Hormone Radioimmunoassay | 1978 |
Effects of Intraduodenal Acid on Gallbladder Net Water Absorption and Motility in the Cat
R Jansson |
Scandinavian Journal of Gastroenterology | 1978 |
Plasma secretin concentrations in fasting and postprandial state in man
WY Chey, YH Lee, JG Hendricks, RA Rhodes, HH Tai |
The American Journal of Digestive Diseases | 1978 |
Mannitol and glucose: Effects on gastric acid secretion and endogenous gastric inhibitory polypeptide (GIP)
TM O'Dorisio, JT Spaeth, EW Martin, KR Sirinek, NR Thomford, EL Mazzaferri, S Cataland |
The American Journal of Digestive Diseases | 1978 |
Effect of secretin on basal- and glucose-stimulated insulin secretion in man
J Fahrenkrug, OB de Muckadell, C Kühl |
Diabetologia | 1978 |
Effects of a protein meal, intraduodenal HCl, and oleic acid on portal and peripheral venous secretin and on pancreatic bicarbonate secretion
G Boden, RM Wilson, N Essa-Koumar, OE Owen |
Gut | 1978 |
Radioimmunoassay of gastrointestinal hormones
E Straus |
Gastroenterology | 1978 |
Intractable diarrhea
GJ Krejs, JH Walsh, SG Morawski, JS Fordtran |
The American Journal of Digestive Diseases | 1977 |
Plasma secretin concentration in man: effect of intraduodenal glucose, fat, amino acids, ethanol, HCI, or ingestion of a meal
J Fahrenkrug, OB de Muckadell |
European Journal of Clinical Investigation | 1977 |
Plasma Secretin Concentration in Anaesthetized Pigs after Intraduodenal Glucose, Fat, Aminoacids, or Meals with Various pH
J Fahrenkrug, OB de Muckadell, JJ Holst |
Scandinavian Journal of Gastroenterology | 1977 |
Plasma Secretin Concentration and Pancreatic Exocrine Secretion after Intravenous Secretin or Intraduodenal HCL in Anaesthetized Pigs
OB de Muckadell, J Fahrenkrug, JJ Holst |
Scandinavian Journal of Gastroenterology | 1977 |
Pancreatic bicarbonate, serum gastrin, and secretin responses to meals varying in pH
OL Llanos, SJ Konturek, PL Rayford, JC Thompson |
American journal of physiology. Endocrinology and metabolism | 1977 |
Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man
WH Hacki, SR Bloom, P Mitznegg, W Domschke, S Domschke, D Belohlavek, L Demling, E Wunsch |
Gut | 1977 |
Radioimmunoassay Measurement of Secretin Half-Life in Man
BE Kolts, JE McGuigan |
Gastroenterology | 1977 |
Intractable diarrhea: Intestinal perfusion studies and plasma VIP concentrations in patients with pancreatic cholera syndrome and surreptitious ingestion of laxatives and diuretics
GJ Krejs, JH Walsh, SG Morawski, JS Fordtran |
The American Journal of Digestive Diseases | 1977 |
The Effect of Meal Feeding and of Sham-Feeding on Insulin Secretion in Dogs
U Fischer, H Hommel, HD Gottschling, W Nowak |
European Journal of Clinical Investigation | 1976 |
Observations on plasma secretion levels by radioimmunoassay in response to duodenal acidification and to a meat meal in humans
RA Rhodes, HH Tai, WY Chey |
The American Journal of Digestive Diseases | 1976 |
Gastrin inhibition of the pyloric sphincter
RS Fisher, G Boden |
The American Journal of Digestive Diseases | 1976 |
Secretin and insulin: Response to intraduodenal acid
FA O'Connor, KD Buchanan, JJ Connon, M Shahidullah |
Diabetologia | 1976 |
Disappearance half-time of endogenous and exogenous secretin in dogs
PJ Curtis, HR Fender, PL Rayford, JC Thompson |
Gut | 1976 |
Stimulation of Secretion of Gastric Inhibitory Polypeptide and Insulin by Intraduodenal Amino Acid Perfusion
FB Thomas, EL Mazzaferri, SE Crockett, HS Mekhjian, HD Gruemer, S Cataland |
Gastroenterology | 1976 |
The Influence of Gastrointestinal Hormones and Prostaglandins on the Lower Oesophageal Sphincter
RS Fisher, S Cohen |
1976 | |
SECRETIN : A NEW ROLE FOR AN OLD HORMONE
RW Henry, RW Flanagan, KD Buchanan |
The Lancet | 1975 |
Somatostatin suppresses secretin and pancreatic exocrine secretion
G Boden, M Sivitz, O Owen, N Essa-Koumar, J Landor |
Science | 1975 |
Effects of Intraduodenal Amino Acids, Fatty Acids, and Sugars on Secretin Concentrations
G Boden, N Essa, OE Owen |
Gastroenterology | 1975 |
Achtzigster Kongress
JF Bergmann |
1974 | |
Candidate Hormones of the Gut
MI Grossman |
Gastroenterology | 1974 |
Gastric Operations and Glucose Homeostasis
RI Breuer, H Moses, TC Hagen, L Zuckerman |
Gastroenterology | 1972 |
Advances in Metabolic Disorders
G Aurbach, JT Potts |
Advances in Metabolic Disorders | 1964 |