Sulfhydryl Groups of the Erythrocyte Membrane and their Relation to Glycolysis and Drug-Induced Hemolytic Anemia

• Text
• PDF

Abstract

Hemolytic anemia caused by oxidative drugs is thought to result from the oxidation of intracellular and membrane sulfhydryl groups of the erythrocyte. This process is more likely to occur in those erythrocytes in which the intracellular mechanism for reduction of disulfides is abnormal (e.g., glucose-6-phosphate dehydrogenase deficiency). If a membrane sulfhydryl group is critical in the pathogenesis of druginduced hemolytic anemia, it follows that this specific group must be dependent on intracellular reductive mechanisms for maintenance of the reduced state.

Authors

Alvin Zipursky, Marlene Stephens, Elizabeth J. Brown, Per Larsen