Studies on the Distribution of Surface Immunoglobulins on Human B-Lymphocytes

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Abstract

Normal human peripheral blood lymphocytes were studied with fluorescent anti-immunoglobulin antibodies and shown to have a patchy distribution of immunoglobulin on their surfaces that does not form a cap after complexing with antibody. Use of freeze-etch electron microscopy confirmed the distribution of immunoglobulin in isolated patches on the membrane. Evidence is presented that this distribution may explain the absence of capping of these human cells as compared with mouse B-lymphocytes.

Authors

Kenneth A. Ault, Morris J. Karnovsky, Emil R. Unanue