Impaired Lymphocyte Transformation in Hodgkin's Disease. EVIDENCE FOR DEPLETION OF CIRCULATING T-LYMPHOCYTES

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Abstract

The kinetics of lymphocyte transformation induced by phytohemagglutinin (PHA) and pokeweed mitogen (PWM) were studied daily, with blood lymphocytes from normal individuals and from untreated patients in all stages of Hodgkin's disease (HD). In addition, spleen lymphocytes and lymph node lymphocytes were studied with similar techniques.

Authors

Kenneth M. Matchett, Andrew T. Huang, William B. Kremer