Citations to this article

Evidence Suggesting Persistence of Nephritogenic Immunopathologic Mechanisms in Patients Receiving Renal Allografts
J. J. McPhaul Jr., … , R. DeLemos, R. B. Smith
J. J. McPhaul Jr., … , R. DeLemos, R. B. Smith
Published May 1, 1973
Citation Information: J Clin Invest. 1973;52(5):1059-1066. https://doi.org/10.1172/JCI107271.
View: Text | PDF
Research Article

Evidence Suggesting Persistence of Nephritogenic Immunopathologic Mechanisms in Patients Receiving Renal Allografts

Abstract

Direct immunofluorescent (IF) examinations and elutions were performed on native kidneys and allografts of 24 patients undergoing renal transplantation. Immunoglobulins (Ig) were detected by IF on native kidneys of 12 of the 24; 11 of the 12 later had Ig localized to allograft glomeruli by direct IF. In addition, three other patients also developed Ig deposition on allograft glomeruli, although direct IF of native kidneys was negative. Elution studies indicated: (a) that linear Ig deposition on allograft glomeruli was the result of antiglomerular basement membrane (GBM) antibodies, (b) Ig localizing to allograft glomeruli in many of these patients was the result of persistent immunopathogenetic mechanisms existing at the time of allograft placement, and (c) occasionally, kidneys negative for Ig localization by direct IF contain elutable nephritogenic antibodies.

Authors

J. J. McPhaul Jr., A. L. Thompson Jr., Robert E. Lordon, G. Klebanoff, A. B. Cosimi, R. DeLemos, R. B. Smith

×

Total citations by year

Year: 2011 1999 1998 1997 1982 1981 1979 1976 1975 1974 1970 Total
Citations: 1 1 2 1 2 2 1 2 1 2 1 16
Citation information

Citations to this article (16)

Title and authors Publication Year
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné 		Advances in Immunology Volume 110 2011
Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis
M Mazzali, MA Ribeiro-Alves, GA Filho 		Sao Paulo Medical Journal 1999
Outcome of renal transplantation in ninety-seven cyclosporine-era patients with systemic lupus erythematosus and matched controls
JH Stone, WJ Amend, LA Criswell 		Arthritis & Rheumatism 1998
Frequency of recurrent lupus nephritis among ninety-seven renal transplant patients during the cyclosporine era
JH Stone, CL Millward, JL Olson, WJ Amend, LA Criswell 		Arthritis & Rheumatism 1998
Outcome of renal transplantation in systemic lupus erythematosus
JH Stone, WJ Amend, LA Criswell 		Seminars in Arthritis and Rheumatism 1997
Evaluation of recurrent glomerulonephritis in kidney allografts
M Morzycka, BP Croker, HF Seigler, CC Tisher 		The American Journal of Medicine 1982
The improving utility of renal transplantation in the management of end-stage renal disease
TB Strom 		The American Journal of Medicine 1982
Specificities of antibodies eluted from human cadaveric renal allografts. Multiple mechanisms of renal allograft injury
JJ McPhaul, P Stastny, RB Freeman 		Journal of Clinical Investigation 1981
Recurrence of antiglomerular basement membrane glomerulonephritis in sheep renal allografts
MP James, PB Herdson, JB Gavin 		Pathology 1981
Renal Medicine
EN Wardle 		1979
Nephritogenic immunopathologic mechanisms and human renal transplants: The problem of recurrent glomerulonephritis
JJ McPhaul, RE Lordon, AL Thompson, JD Mullins 		Kidney International 1976
Immunologic Tests for Rejection
MN Gottlieb, MR Garovoy, CB Carpenter 		The Urologic clinics of North America 1976
Glomerulopathies in Human Renal Allografts
P Rossmann, J Jirka, P Málek, J Hejnal 		Beiträge zur Pathologie 1975
Diagnosis of immunopathologic renal disease
CB Wilson, FJ Dixon 		Kidney International 1974
Renal homotransplantation
TE Starzl, KA Porter, BS Husberg, M Ishikawa, CW Putnam 		Current Problems in Surgery 1974
Glomerulonephritis
JS Cameron 		British medical journal 1970

Advertisement