Advertisement
Research Article Free access | 10.1172/JCI107271
Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Find articles by McPhaul, J. in: JCI | PubMed | Google Scholar
Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Find articles by Thompson, A. in: JCI | PubMed | Google Scholar
Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Find articles by Lordon, R. in: JCI | PubMed | Google Scholar
Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Find articles by Klebanoff, G. in: JCI | PubMed | Google Scholar
Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Find articles by Cosimi, A. in: JCI | PubMed | Google Scholar
Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Find articles by DeLemos, R. in: JCI | PubMed | Google Scholar
Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236
Find articles by Smith, R. in: JCI | PubMed | Google Scholar
Published May 1, 1973 - More info
Direct immunofluorescent (IF) examinations and elutions were performed on native kidneys and allografts of 24 patients undergoing renal transplantation. Immunoglobulins (Ig) were detected by IF on native kidneys of 12 of the 24; 11 of the 12 later had Ig localized to allograft glomeruli by direct IF. In addition, three other patients also developed Ig deposition on allograft glomeruli, although direct IF of native kidneys was negative. Elution studies indicated: (a) that linear Ig deposition on allograft glomeruli was the result of antiglomerular basement membrane (GBM) antibodies, (b) Ig localizing to allograft glomeruli in many of these patients was the result of persistent immunopathogenetic mechanisms existing at the time of allograft placement, and (c) occasionally, kidneys negative for Ig localization by direct IF contain elutable nephritogenic antibodies.