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Citations to this article

An Effect of Dexamethasone on Adenosine 3′,5′ -Monophosphate Content and Adenosine 3′,5′ -Monophosphate Phosphodiesterase Activity of Cultured Hepatoma Cells
Vincent Manganiello, Martha Vaughan
Vincent Manganiello, Martha Vaughan
Published October 1, 1972
Citation Information: J Clin Invest. 1972;51(10):2763-2767. https://doi.org/10.1172/JCI107096.
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Research Article

An Effect of Dexamethasone on Adenosine 3′,5′ -Monophosphate Content and Adenosine 3′,5′ -Monophosphate Phosphodiesterase Activity of Cultured Hepatoma Cells

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Abstract

The effect of dexamethasone on adenosine 3′,5′-monophosphate (cAMP) phosphodiesterase activity in cultured HTC hepatoma cells was investigated. Homogenates of these cells contain phosphodiesterase activity with two apparent Michaelis constants for cAMP (2-5 μm and 50 μm). At all substrate concentrations tested, phosphodiesterase activity was decreased 25-40% in cells incubated for 36 hr or more with 1 μm dexamethasone. Acid phosphatase activity in the same cells was not decreased. α-Methyl testosterone, 1 μm, was without effect on phosphodiesterase activity.

Authors

Vincent Manganiello, Martha Vaughan

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Total citations by year

Year: 2022 2019 2012 2011 2010 2009 2008 2005 2002 2001 1998 1995 1994 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1973 1968 Total
Citations: 2 1 1 2 1 1 1 1 1 1 1 1 2 4 2 1 6 3 7 2 3 4 5 5 7 9 5 4 6 7 1 97
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