The function of carbonic anhydrase in H+ secretion by the turtle bladder was studied in vitro. Dose response curves were obtained for the carbonic anhydrase inhibitors, acetazolamide and ethoxzolamide, with and without addition of CO2 to the system. In addition, carbonic anhydrase was assayed in homogenates of mucosal cells. The activity in the homogenates was 155±16 U/g dry wt, of which only 11 U represented contamination from erythrocytes; after addition of 5 × 10−6m acetazolamide, no enzyme activity was detectable.
John H. Schwartz, Seymour Rosen, Philip R. Steinmetz
Title and authors | Publication | Year |
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The Renal Physiology of Pendrin-Positive Intercalated Cells
SM Wall, JW Verlander, CA Romero |
Physiological reviews | 2020 |
Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS
WN Suki, SG Massry |
1997 | |
Renal acid-base transport: The regulatory role of the inner medullary collecting duct
JH Schwartz |
Kidney International | 1995 |
Rat Urinary Bladder Hyperplasia Induced by Oral Administration of Carbonic Anhydrase Inhibitors
S Molon-Noblot, C Boussiquet-Leroux, RA Owen, E Irisarri, G Durand-Cavagna, CP Peter, P Duprat |
Toxicologic pathology | 1992 |
Evaluation of carbonic anhydrase isozymes in disorders involving osteopetrosis and/or renal tubular acidosis
WS Sly, S Sato, XL Zhu |
Clinical Biochemistry | 1991 |
Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient patients
S Sato, XL Zhu, WS Sly |
Proceedings of the National Academy of Sciences | 1990 |
Isolation and culture of HCO3- -secreting intercalated cells
JV Adelsberg, JC Edwards, D Herzlinger, C Cannon, M Rater, Q al-Awqati |
American journal of physiology. Cell physiology | 1989 |
Localization of transport compartments in turtle urinary bladder
P Buchinger, P Wienecke, R Rick, F Beck, A Drge, K Thurau |
Pflügers Archiv - European Journal of Physiology | 1989 |
Transfusion of carbonic anhydrase-replete erythrocytes fails to correct the acidification defect in the syndrome of osteopetrosis, renal tubular acidosis, and cerebral calcification (Carbonic Anhydrase-II Deficiency)
MP Whyte, LL Hamm, WS Sly |
Journal of Bone and Mineral Research | 1988 |
Vasoactive intestinal peptide stimulates alkali excretion in turtle urinary bladder
JH Durham, C Matons, WA Brodsky |
American journal of physiology. Cell physiology | 1987 |
Regulation of cell pH by Ca+2-mediated exocytotic insertion of H+-ATPases
J Adelsberg, Q Al-Awqati |
The Journal of Cell Biology | 1986 |
Proton transport and membrane shuttling in turtle bladder epithelium
TE Dixon, C Clausen, D Coachman, B Lane |
The Journal of Membrane Biology | 1986 |
Histochemical localization of carbonic anhydrase in the pig's exocrine pancreas
T Buanes, T Grotmol, T Landsverk, Y Ridderstråle, MG RaeDER |
Acta Physiologica Scandinavica | 1986 |
Evidence for separate cellular origins of sodium and acid-base transport in the turtle bladder
JH Durham, W Nagel |
American journal of physiology. Cell physiology | 1986 |
Membrane electrical parameters in turtle bladder measured using impedance-analysis techniques
C Clausen, TE Dixon |
The Journal of Membrane Biology | 1986 |
Effects of parathyroid hormone and calcitonin on carbonic anhydrase location in osteoclasts of cultured embryonic chick bone
H Cao, CV Gay |
Experientia | 1985 |
Effect of cyclic AMP on acidification in the isolated turtle bladder
S Sabatini |
Kidney International | 1985 |
Therapy of Renal Diseases and Related Disorders
WN Suki, SG Massry |
1984 | |
Current Topics in Membranes and Transport
J Gliemann, WD Rees |
Current Topics in Membranes and Transport | 1983 |
Role of membrane fusion in CO2 stimulation of proton secretion by turtle bladder
DL Stetson, PR Steinmetz |
American journal of physiology. Cell physiology | 1983 |
Electrogenic proton transport in epithelial membranes
PR Steinmetz, OS Andersen |
The Journal of Membrane Biology | 1982 |
Elevated urinary PCO2 in the rat: An intrarenal event
ML Graber, HH Bengele, EA Alexander |
Kidney International | 1982 |
Exocytosis regulates urinary acidification in turtle bladder by rapid insertion of H+ pumps into the luminal membrane
S Gluck, C Cannon, Q Al-Awqati |
Proceedings of the National Academy of Sciences | 1982 |
Ultrastructural immunocytochemical localization of carbonic anhydrase in normal and calcitonin-treated chick osteoclasts
RE Anderson, H Schraer, CV Gay |
The Anatomical Record | 1982 |
Surface characteristics of carbonic-anhydrase-rich cells in turtle urinary bladder
RF Husted, AL Mueller, RG Kessel, PR Steinmetz |
Kidney International | 1981 |
FUNCTIONAL ORGANIZATION OF PROTON AND BICARBONATE TRANSPORT IN TURTLE URINARY BLADDER
PR Steinmetz, LH Cohen, RF Husted, A Mueller |
Annals of the New York Academy of Sciences | 1980 |
Control of active proton transport in turtle urinary bladder by cell pH
LH Cohen, PR Steinmetz |
The Journal of General Physiology | 1980 |
Effect of cyclic AMP on hydrogen ion secretion by turtle urinary bladder
PD Lief, BF Mutz, N Bank |
Kidney International | 1979 |
Effect of plasma H+-ion concentration on pancreatic HCO-3secretion
M Raeder, A Mo, S Aune |
Acta Physiologica Scandinavica | 1979 |
Toad carbonic anhydrase: Purification of the enzyme from erythrocytes of Bufo marinus and comparison with the enzyme activity in the urinary bladder
WN Scott, I Skipski |
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry | 1979 |
Inhibition of the Bicarbonate Exit Step in Urinary Acidification by a Disulfonic Stilbene
LH Cohen, A Mueller, PR Steinmetz |
Journal of Clinical Investigation | 1978 |
Relationship between the Rate of H+ Transport and Pathways of Glucose Metabolism by Turtle Urinary Bladder
LH Norby, JH Schwartz |
Journal of Clinical Investigation | 1978 |
Physiology of Membrane Disorders
TE Andreoli, JF Hoffman, DD Fanestil |
1978 | |
Influence of transepithelial potential difference on acidification in the toad urinary bladder
TW Ziegler, DD Fanestil, JH Ludens |
Kidney International | 1976 |
Active H+ transport in the turtle urinary bladder. Coupling of transport to glucose oxidation
R Beauwens, Q Al-Awqati |
The Journal of General Physiology | 1976 |
Energy dependence of urinary bicarbonate secretion in turtle bladder
JA Oliver, S Himmelstein, PR Steinmetz |
Journal of Clinical Investigation | 1975 |
Urinary acidification and carbonic anhydrase distribution in bladders of Dominican and Colombian toads
S Rosen, JA Oliver, PR Steinmetz |
The Journal of Membrane Biology | 1974 |
Directional instability and oscillation of the acid-base transport system of the tortoise urinary bladder, Damonia subtrijuga
GJ Leitch, N Kotchabhakdi |
Comparative Biochemistry and Physiology Part A: Physiology | 1974 |
Carbonic anhydrase activity in Rana pipiens skin: biochemical and histochemical analysis
S Rosen, NJ Friedley |
Histochemie | 1973 |
Localization of carbonic anhydrase activity in the vertebrate retina
GL Musser, S Rosen |
Experimental Eye Research | 1973 |
Carbonic anhydrase activity in amphibian and reptilian lung: a histochemical and biochemical analysis
W Fain, S Rosen |
The Histochemical Journal | 1973 |
Carbonic anhydrase activity in Rana pipiens skin: biochemical and histochemical analysis
S Rosen, NJ Friedley |
Histochemistry and Cell Biology | 1973 |
Localization of carbonic anhydrase activity in the vertebrate nephron.
Rosen S |
The Histochemical Journal | 1972 |