Renal hemodynamics and tubular fractional sodium reabsorption (FSR) were evaluated by clearance techniques during acute and chronic extracellular volume expansion in man. (1 − V/GFR) × 100 was used as an index of proximal and (CH2O/V) × 100 as an estimate of distal fractional reabsorption. After acute loading with isotonic saline 37 ml/kg body wt, proximal FSR decreased by 4.8% and distal FSR decreased by 4.4%. After comparable chronic expansion by mineralocorticoids (“escape”), proximal FSR also decreased by 3.9%, but distal reabsorption was not altered.
Edward A. Alexander, David W. Doner Jr., R. Brewer Auld, Norman G. Levinsky
Title and authors | Publication | Year |
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Glomerular hyperfiltration in patients with well-compensated alcoholic cirrhosis
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Evaluation of lithium clearance as a marker of proximal tubule sodium handling
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Kidney International | 1989 |
Peripheral arterial vasodilation hypothesis: A proposal for the initiation of renal sodium and water retention in cirrhosis
RW Schrier, V Arroyo, M Bernardi, M Epstein, JH Henriksen, J Rodés |
Hepatology | 1988 |
Renal sodium retention in cirrhosis: Tubular site and relation to hepatic dysfunction
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Hepatology | 1988 |
Lithium clearance during the paradoxical natriuresis of hypotonic expansion in man
WH Boer, HA Koomans, EJ Mees |
Kidney International | 1987 |
The Pituitary Gland
CR Kannan |
1987 | |
X-ray microanalysis of cardiocytes in the Snell dwarf mouse
NK Smith, A Lewiński, A Bartke, S Stabler-Morris |
Biochemical and Biophysical Research Communications | 1983 |
FACTORS RELATING TO ALDOSTERONE SECRETION RATE, THE EXCRETION OF ALDOSTERONE 18-GLUCURONIDE, AND THE PLASMA ALDOSTERONE CONCENTRATION IN CIRRHOSIS
SP Wilkinson, PG Wheeler, TP Jowett, IK Smith, J Keenan, JD Slater, R Williams |
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Renal Handling Of Sodium and Water in Early Chronic Liver Disease
R Naccarato, P Messa, A D'Angelo, A Fabris, M Messa, M Chiaramonte, C Gregolin, G Zanon |
Gastroenterology | 1981 |
Renal response to graded intravenous hypertonic NaCl infusion in healthy and hypertensive subjects:dose-related impairment in distal NaCl reabsorption
JP Radó, E Juhos, EJ Mees |
American Heart Journal | 1980 |
Natriuretic Hormone
HJ Kramer, F Krück |
1978 | |
Antinatriferic activity in human plasma following acute and chronic salt-loading
HJ Kramer, A Bäcker, F Krück |
Kidney International | 1977 |
Renal Changes during Pregnancy: Their Relevance to Volume Homeostasis
MD Lindheimer, AI Katz |
1975 | |
The Effect of Glucose on Urinary Cation Excretion during Chronic Extracellular Volume Expansion in Normal Man
EJ Lennon, J Lemann, WF Piering, LS Larson |
Journal of Clinical Investigation | 1974 |
Effect of glucose and other carbohydrates on the toad's glomerular pressure
J Uranga |
Comparative Biochemistry and Physiology Part A: Physiology | 1974 |
Advances in Metabolic Disorders
G Aurbach, JT Potts |
Advances in Metabolic Disorders | 1964 |