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Concise Publication Free access | 10.1172/JCI106996

Dihydrotachysterol: a calcium active steroid not dependent upon kidney metabolism

Harold E. Harrison and Helen C. Harrison

Department of Pediatrics, Baltimore City Hospitals, Baltimore, Maryland 21224

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224

Find articles by Harrison, H. in: JCI | PubMed | Google Scholar

Department of Pediatrics, Baltimore City Hospitals, Baltimore, Maryland 21224

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224

Find articles by Harrison, H. in: JCI | PubMed | Google Scholar

Published July 1, 1972 - More info

Published in Volume 51, Issue 7 on July 1, 1972
J Clin Invest. 1972;51(7):1919–1922. https://doi.org/10.1172/JCI106996.
© 1972 The American Society for Clinical Investigation
Published July 1, 1972 - Version history
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Abstract

The activity of dihydrotachysterol and cholecalciferol was determined in nephrectomized or sham-operated vitamin D-depleted rats using in vitro transport of calcium and phosphate by everted intestinal preparations as the index of physiologic response. The activity of dihydrotachysterol was not reduced by absence of the kidneys whereas that of cholecalciferol was markedly inhibited so that at least a 10-fold greater dose of the latter was necessary to produce an equivalent effect in the nephrectomized rat as in the control. Dihydrotachysterol is therefore equipotent with cholecalciferol in the anephric rat although much less active in the intact animal.

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