Prostaglandins and Their Effects on Human Placental Adenyl Cyclase

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Abstract

Prostaglandins increased adenyl cyclase activity in human term placental homogenates in a dose-dependent manner during 10-min incubation periods. The potency of the prostaglandins examined was demonstrated to be in the ascending order, prostaglandin F1α < A2, F2α, B2 < A1 < E2 < E1. Although no specific trophic or regulating factors for placental function have been described as yet, it is possible that prostaglandins which are synthesized in decidual tissue could play such a physiological role.

Authors

Kazuo Satoh, Kenneth J. Ryan