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Concise Publication Free access | 10.1172/JCI106832

Prostaglandins and Their Effects on Human Placental Adenyl Cyclase

Kazuo Satoh and Kenneth J. Ryan

Department of Obstetrics and Gynecology, School of Medicine, University of California, San Diego, La Jolla, California 92037

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Department of Obstetrics and Gynecology, School of Medicine, University of California, San Diego, La Jolla, California 92037

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Published February 1, 1972 - More info

Published in Volume 51, Issue 2 on February 1, 1972
J Clin Invest. 1972;51(2):456–458. https://doi.org/10.1172/JCI106832.
© 1972 The American Society for Clinical Investigation
Published February 1, 1972 - Version history
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Abstract

Prostaglandins increased adenyl cyclase activity in human term placental homogenates in a dose-dependent manner during 10-min incubation periods. The potency of the prostaglandins examined was demonstrated to be in the ascending order, prostaglandin F1α < A2, F2α, B2 < A1 < E2 < E1. Although no specific trophic or regulating factors for placental function have been described as yet, it is possible that prostaglandins which are synthesized in decidual tissue could play such a physiological role.

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